红花注射液关节腔冲洗结合钩针治疗膝骨性关节炎的临床疗效观察

发布时间：2019-01-03 06:23

【摘要】：目的通过采用红花注射液关节腔冲洗结合钩针治疗膝关节骨性关节炎,依据Lysholm膝关节评分、膝关节HSS评分法评价其临床疗效,总结分析红花注射液关节腔冲洗结合钩针治疗膝关节骨性关节炎的临床疗效。方法采用临床随机对照法进行研究,选择2014年11月至2015年5月就诊于山西省中西医结合医院疼痛科且符合纳入标准的膝关节骨性关节炎住院患者,临床收集90例,年龄50—80岁,并依据患者就诊顺序按Doll’s随机数字表法分为生理盐水冲洗组(A组)、红花注射液关节腔冲洗组(B组)、红花注射液关节腔冲洗结合钩针治疗组(C组),A组为对照组,B组和C组为试验组,每组各30例。治疗前依据Lysholm膝关节评分、膝关节HSS评分法进行治疗前评分,完善相关辅助检查后对符合纳入标准的患者分别采用上述三种方法进行治疗,各治疗两次。患者治疗结束后一周及出院1月后随访,依据Lysholm膝关节评分、膝关节HSS评分法进行评分。临床研究的数据资料采用SPSS 17.0统计软件分析,对所获数据采用完全随机的多组样本均数比较,使用单因素方差分析法(ANOVA),数据以x±S表示,以P0.05为有差异性,具有统计学意义。若数据呈正态分布,方差齐,且各组数值之间有统计学意义,用LSD检验进行多重比较分析;若方差不齐,在有统计学意义的基础上,采用Tamhane’s T2检验进行多重比较。结果(1)三组在患者年龄、性别、病程、单双膝关节数量方面比较,经方差分析检验,P0.05,差异无统计学意义;(2)三组患者治疗前Lysholm膝关节评分、膝关节HSS评分比较,经方差分析检验,P0.05,差异无统计学意义;(3)三组患者治疗前病情严重程度比较,经方差分析检验,P0.05,差异无统计学意义;(4)治疗后1周及治疗后1月与治疗前对比,依据Lysholm膝关节评分、膝关节HSS评分法比较,经方差分析检验,三组P值均0.05,差异有统计学意义;(5)治疗后1周三组之间进行疗效对比,A组与B组相比,经方差分析检验,P0.05,差异无统计学意义,A组与C组相比,P0.05,差异有统计学意义,B组与C组相比,P0.05,差异有统计学意义;(6)治疗后1月三组之间进行疗效对比,经方差分析检验,依据Lysholm膝关节评分,A组与B组相比,P0.05,差异无统计学意义,A组与C组相比,P0.05,差异有统计学意义,B组与C组相比,P0.05,差异有统计学意义;而依据膝关节HSS评分,三组之间对比,P值均0.05,差异有统计学意义;(7)治疗后1周及治疗后1月三组之间总体疗效对比,经方差分析检验,P0.05,差异具有统计学意义,可以认为三组疗效有差异,而C组总体疗效均优于A组和B组。结论红花注射液关节腔冲洗结合钩针治疗膝骨性关节炎较单纯采用关节腔冲洗相比,取得较好临床疗效,是治疗KOA安全有效、疗效确切的方法。
[Abstract]:Objective to evaluate the clinical efficacy of safflower injection combined with crochet needle in the treatment of knee osteoarthritis according to Lysholm knee score and knee joint HSS score. To summarize and analyze the clinical effect of safflower injection combined with crochet needle in the treatment of knee osteoarthritis. Methods from November 2014 to May 2015, 90 patients with knee osteoarthritis, who were admitted to the pain Department of Shanxi Integrated Chinese and Western Medicine Hospital and met the inclusion criteria, were selected from a randomized controlled clinical study. The patients aged 50-80 years were randomly divided into two groups: saline irrigation group (group A) and safflower injection joint cavity irrigation group (group B) according to the Doll's sequence. Safflower injection combined with crochet needle treatment group (group C), A as control group, B group and C group as experimental group, 30 cases in each group). According to the Lysholm knee joint score and the knee joint HSS score before treatment, the patients who met the inclusion criteria were treated with the above three methods respectively, two times each after the improvement of relevant auxiliary examination. The patients were followed up one week after treatment and one month after discharge. According to Lysholm knee score and knee joint HSS score. The data of clinical study were analyzed by SPSS 17.0 statistical software. The data were compared with each other by random multi-group sample mean. The (ANOVA), data of single factor variance analysis was expressed as x 卤S, and the difference was P0.05. It has statistical significance. If the data is normal distribution, the variance is homogeneous, and there is statistical significance among the values of each group, the LSD test is used to carry out multiple comparative analysis; if the variance is not uniform, on the basis of statistical significance, the Tamhane's T2 test is used to carry out multiple comparisons. Results (1) there was no significant difference among the three groups in age, sex, course of disease and the number of single and double knee joints. The variance analysis showed that there was no significant difference between the three groups in age, sex, course of disease and the number of single and double knee joints. (2) there was no significant difference in Lysholm knee joint score and knee joint HSS score between the three groups before treatment (P 0.05). (3) there was no significant difference in the severity of the disease between the three groups before treatment (P 0.05). (4) 1 week after treatment and 1 month after treatment compared with before treatment, according to Lysholm knee joint score, knee joint HSS score comparison, by variance analysis test, the three groups P value were 0.05, the difference was statistically significant; (5) there was no significant difference between group A and group B by ANOVA test (P0.05), the difference between group A and group C (P0.05) was statistically significant, the difference between group A and group C was statistically significant, and the difference between group B and group C was statistically significant. P0.05, the difference was statistically significant. (6) after 1 month of treatment, the curative effect was compared among the three groups. According to the Lysholm knee joint score, there was no significant difference between group A and group B (P0.05, P 0.05, P 0.05). The difference was statistically significant, compared with group C, P 0.05, the difference was statistically significant. According to the HSS score of knee joint, there were significant differences among the three groups (P = 0.05). (7) the total curative effect of group C was better than that of group A and B after 1 week of treatment and 1 month after treatment. The variance analysis showed that the difference was statistically significant (P0.05), and the total curative effect of group C was better than that of group A and B. Conclusion the safflower injection combined with crochet needle in the treatment of knee osteoarthritis has a better clinical effect than that of simple joint cavity washing. It is a safe and effective method for the treatment of KOA.
【学位授予单位】：山西中医学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R274.9

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