合并高尿酸血症的慢性肾小球肾炎中医学研究
发布时间：2019-01-05 20:20
【摘要】：目的:通过探究慢性肾小球肾炎(CKD 1-3期)患者的血尿酸水平和性别、年龄、高血压病史、CKD分期、中医证型之关系,以期为伴有高尿酸血症的慢性肾小球肾炎患者的中医治疗提供参考依据。材料与方法:收集2014年1月份至2015年12月份在辽宁中医药大学附属医院肾内科诊断为慢性肾小球肾炎患者(CKD 1-3期)的临床信息,共计97例,并且根据血尿酸的不同程度,分为正常尿酸组43例,高尿酸血症组54例,采用统计学方法分析两组病例性别、年龄、高血压病史、CKD分期以及中医的证型特点。结果:1.慢性肾小球肾炎患者(CKD 1-3期)高尿酸血症组和正常尿酸组在性别、年龄分布方面差异无统计学意义(P0.05)。2.慢性肾小球肾炎患者(CKD 1-3期)高尿酸血症组的高血压患病率明显高于正常血尿酸组,差异具有统计学意义(P0.05)。3.慢性肾小球肾炎患者(CKD 1-3期)高尿酸血症组和正常尿酸组在CKD分期方面差异具有统计学意义(P0.05)。4.慢性肾小球肾炎患者(CKD 1-3期)高尿酸血症组的湿热证发生率高于正常尿酸组,差异具有统计学意义(P0.05)。结论:1.血尿酸水平升高和高血压疾病之间通过多种机制相互作用,形成恶性循环,加速肾脏功能损害,所以应该积极控制慢性肾小球肾炎患者的血尿酸水平及血压水平。2.血尿酸水平升高不仅标志着肾脏功能的减退,而且在慢性肾脏病的病程中发挥重要作用,所以控制慢性肾小球肾炎患者血尿酸水平对延缓病情进展具有不容忽视的意义。3.对于合并高尿酸血症的慢性肾小球肾炎患者可酌情运用具有清热化湿功效的中药,有利于缓解湿热证的临床表现,减轻血尿酸程度,延缓病变进展。
[Abstract]:Objective: to investigate the relationship between serum uric acid level, sex, age, history of hypertension, CKD stage and TCM syndromes in patients with chronic glomerulonephritis (CKD 1-3). In order to provide reference for the treatment of chronic glomerulonephritis with hyperuricemia. Materials and methods: 97 patients with chronic glomerulonephritis (CKD 1-3) were collected from January 2014 to December 2015 in the Department of Nephrology, affiliated Hospital of Liaoning University of traditional Chinese Medicine. The patients were divided into normal uric acid group (n = 43) and hyperuricemia group (n = 54). Sex, age, hypertension history, CKD stage and TCM syndromes were analyzed by statistical method. Results: 1. There was no significant difference in sex and age distribution between hyperuricemia group and normal uric acid group in patients with chronic glomerulonephritis (CKD 1-3 stage) (P0.05). The prevalence of hypertension in patients with chronic glomerulonephritis (CKD 1-3 stage) with hyperuricemia was significantly higher than that with normal uric acid (P0.05). Chronic glomerulonephritis patients (CKD 1-3) hyperuricemia group and normal uric acid group in CKD staging differences were statistically significant (P0.05). 4. The incidence of damp-heat syndrome in patients with chronic glomerulonephritis (CKD 1-3 stage) with hyperuricemia was higher than that in normal uric acid group (P0.05). Conclusion: 1. The increase of serum uric acid level and hypertension through a variety of mechanisms of interaction, forming a vicious circle, accelerate the damage of renal function, so we should actively control the level of blood uric acid and blood pressure in patients with chronic glomerulonephritis. 2. 2. The elevated level of uric acid not only marks the decline of renal function, but also plays an important role in the course of chronic kidney disease. Therefore, it is important to control the level of uric acid in patients with chronic glomerulonephritis to delay the progression of the disease. 3. For patients with chronic glomerulonephritis complicated with hyperuricemia, Chinese medicine with the effect of clearing heat and removing dampness can be used as appropriate, which is helpful to alleviate the clinical manifestation of damp-heat syndrome, reduce the degree of blood uric acid, and delay the progress of pathological changes.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5
，
本文编号：2402259
[Abstract]:Objective: to investigate the relationship between serum uric acid level, sex, age, history of hypertension, CKD stage and TCM syndromes in patients with chronic glomerulonephritis (CKD 1-3). In order to provide reference for the treatment of chronic glomerulonephritis with hyperuricemia. Materials and methods: 97 patients with chronic glomerulonephritis (CKD 1-3) were collected from January 2014 to December 2015 in the Department of Nephrology, affiliated Hospital of Liaoning University of traditional Chinese Medicine. The patients were divided into normal uric acid group (n = 43) and hyperuricemia group (n = 54). Sex, age, hypertension history, CKD stage and TCM syndromes were analyzed by statistical method. Results: 1. There was no significant difference in sex and age distribution between hyperuricemia group and normal uric acid group in patients with chronic glomerulonephritis (CKD 1-3 stage) (P0.05). The prevalence of hypertension in patients with chronic glomerulonephritis (CKD 1-3 stage) with hyperuricemia was significantly higher than that with normal uric acid (P0.05). Chronic glomerulonephritis patients (CKD 1-3) hyperuricemia group and normal uric acid group in CKD staging differences were statistically significant (P0.05). 4. The incidence of damp-heat syndrome in patients with chronic glomerulonephritis (CKD 1-3 stage) with hyperuricemia was higher than that in normal uric acid group (P0.05). Conclusion: 1. The increase of serum uric acid level and hypertension through a variety of mechanisms of interaction, forming a vicious circle, accelerate the damage of renal function, so we should actively control the level of blood uric acid and blood pressure in patients with chronic glomerulonephritis. 2. 2. The elevated level of uric acid not only marks the decline of renal function, but also plays an important role in the course of chronic kidney disease. Therefore, it is important to control the level of uric acid in patients with chronic glomerulonephritis to delay the progression of the disease. 3. For patients with chronic glomerulonephritis complicated with hyperuricemia, Chinese medicine with the effect of clearing heat and removing dampness can be used as appropriate, which is helpful to alleviate the clinical manifestation of damp-heat syndrome, reduce the degree of blood uric acid, and delay the progress of pathological changes.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.5
，
本文编号：2402259
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