丹参川穹嗪辅助治疗急性脑梗死对血液流变学及炎性细胞因子的影响

发布时间：2019-01-07 13:11

【摘要】：目的探讨丹参川穹嗪辅助治疗急性脑梗死对血液流变学及炎性细胞因子的影响。方法将118例急性脑梗死患者随机分成观察组与对照组,每组59例,对照组给予常规对症治疗,观察组在常规对症治疗基础上联合丹参川穹嗪治疗,两组疗程均为2周。观察两组患者治疗前后血液流变学及炎性细胞因子变化。结果观察组治疗后血浆高切黏度、红细胞压积、纤维蛋白原水平分别为(2.53±0.26)m Pa·s、(0.45±0.03)、(3.41±0.91)g/L,均较本组治疗前显著降低(t=7.340,2.635,3.954,P0.01);对照组治疗后血浆高切黏度、纤维蛋白原水平分别为(2.82±0.35)m Pa·s、(3.76±0.98)g/L,较本组治疗前明显降低(t=2.111,2.068,P0.05),红细胞压积水平治疗前后无统计学差异;观察组治疗后血浆高切黏度、红细胞压积及纤维蛋白原水平均明显低于对照组(t=5.109,2.207,2.010,P0.05)。两组患者治疗后IL-6、IL-8、IL-1β水平分别为(5.61±2.20)ng/L、(69.81±20.32)ng/L、(16.32±8.17)pg/m L、(9.46±3.18)ng/L、(183.15±58.67)ng/L、(23.76±9.82)pg/m L,均较本组治疗前水平显著降低(t=15.052,36.189,10.994,8.455,17.106,8.269,P0.01),观察组IL-6、IL-8、IL-1β水平均显著低于对照组(t=7.647,14.021,4.473,P0.01)。结论丹参川穹嗪辅助治疗急性脑梗死可明显改善血液流变学,有效减轻炎症反应,对提高临床疗效具有重要作用。
[Abstract]:Objective to investigate the effect of danshen dome on hemorheology and inflammatory cytokines in patients with acute cerebral infarction. Methods 118 patients with acute cerebral infarction were randomly divided into observation group (n = 59) and control group (n = 59). The control group was treated with routine symptomatic therapy. The changes of hemorheology and inflammatory cytokines were observed before and after treatment. Results the plasma high shear viscosity, hematocrit and fibrinogen levels in the observation group were (2.53 卤0.26) m Pa s, () 0.45 卤0.03), (3.41 卤0.91) g / L, respectively. All of them were significantly lower than those before treatment (t = 7.340, 2.6353.954, P0.01). The plasma high shear viscosity and fibrinogen level in the control group were (2.82 卤0.35) m Pa s, (3.76 卤0.98) g / L after treatment, which were significantly lower than those before treatment (t = 2.111 卤2.068 P 0.05). There was no statistical difference in hematocrit before and after treatment. The plasma high shear viscosity, hematocrit and fibrinogen levels in the observation group were significantly lower than those in the control group after treatment (t = 5.109, 2.207, 2.010, P 0.05). The levels of IL-6,IL-8,IL-1 尾 after treatment were (5.61 卤2.20) ng/L, (69.81 卤20.32) ng/L, (16.32 卤8.17) pg/m L, (9.46 卤3.18) ng/L, respectively. (183.15 卤58.67) ng/L, (23.76 卤9.82) pg/m / L, which were significantly lower than those before treatment (t 15.052U 36.189 卤10.994 卤8.455n 17.106t 8.269t P0.01). IL-6,IL-8, in the observation group was significantly lower than that in the control group (P 0.01). The level of IL-1 尾 was significantly lower than that of the control group (t = 7.647 ~ 14.021 ~ 4.473, P0.01). Conclusion the adjuvant treatment of Danshen dronosin for acute cerebral infarction can obviously improve hemorheology, reduce inflammation effectively, and play an important role in improving clinical efficacy.
【作者单位】：宜春市人民医院神经内科;
【分类号】：R277.7

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