参芎益心汤对稳定型心绞痛患者血脂及同型半胱氨酸的影响

发布时间：2019-01-07 13:19

【摘要】：目的：通过观察参芎益心汤对稳定型心绞痛(气虚血瘀型)患者血脂、同型半胱氨酸、生活质量等指标的影响,探讨其临床疗效。方法：将60例确诊为冠心病稳定型心绞痛,中医辨证为气虚血瘀型的患者随机分为治疗组、对照组,各30例。对照组给予西医规范治疗,治疗组在西医规范治疗的基础上加用参芎益心汤,观察时间为4周,观察两组患者治疗前后心绞痛症状、中医症侯、心电图以及血脂、同型半胱氨酸、生活质量等指标的改善情况,对其进行疗效评价,并常规监测不良反应指标。结果：1、心绞痛疗效：治疗组总有效率为90%,对照组总有效率为70%,两组比较,差异有统计学意义(P0.01)。2、心电图疗效：治疗组总有效率为63.33%,对照组总有效率为60%,两组比较,差异无统计学意义(P0.05)。3、中医症候疗效：治疗组总有效率为93.33%,对照组总有效率为66.67%,两组比较,差异有统计学意义(P0.01)。4、血脂改变情况：与治疗前比较,两组均有改善,差异有统计学意义(P0.05)；治疗后与对照组比较：治疗组TC、LDL-C水平降低,差异有统计学意义(P0.01)；TG、HDL-C水平改变,差异无统计学意义(P0.05)。5、同型半胱氨酸改变情况：与治疗前相比,治疗组与对照组HCY水平均有降低,差异有统计学意义(P0.05)；治疗后与对照组比较,治疗组HCY水平降低,差异有统计学意义(P0.05)。6、生活质量改善方面：与治疗前相比,治疗组与对照组PL、AS、AF、TS、DP评分情况及五项积分和均有升高,差异有统计学意义(P0.05)；治疗后与对照组比较,治疗组PL、AS、AF、TS、DP评分情况及五项积分和较高,差异有统计学意义(P0.05)。结论：1、参芎益心汤能够改善患者的心绞痛症状,中医症候以及生存质量。2、参芎益心汤可以降低患者TC、LDL-C以及同型半胱氨酸的水平。
[Abstract]:Objective: to observe the effect of Shenxiong Yixin decoction on blood lipid, homocysteine and quality of life in patients with stable angina pectoris. Methods: 60 cases of stable angina pectoris of coronary heart disease and 30 cases of TCM syndrome differentiation of Qi deficiency and blood stasis were randomly divided into treatment group and control group. The control group was treated with western medicine standard, the treatment group was treated with Shenxiong Yixin decoction on the basis of western medicine standard treatment, the observation time was 4 weeks. The symptoms of angina pectoris, TCM symptoms, electrocardiogram and blood lipid were observed before and after treatment. The improvement of homocysteine and quality of life was evaluated and the adverse reaction index was monitored. Results: 1. The total effective rate of angina pectoris: the total effective rate of the treatment group was 90 and the total effective rate of the control group was 70. The difference between the two groups was statistically significant (P0.01). The effect of electrocardiogram: the total effective rate of the treatment group was 63.33. The total effective rate of the control group was 60. There was no significant difference between the two groups (P0.05). The curative effect of TCM symptom: the total effective rate of the treatment group was 93.333.The total effective rate of the control group was 66.67. The difference was statistically significant (P0.01). 4. The changes of blood lipid: compared with before treatment, the two groups were improved, the difference was statistically significant (P0.05); After treatment compared with the control group: the level of TC,LDL-C in the treatment group decreased, the difference was statistically significant (P0.01); The change of TG,HDL-C level was not statistically significant (P0.05). The change of homocysteine: compared with before treatment, the level of HCY in treatment group and control group were lower, the difference was statistically significant (P0.05). Compared with the control group, the level of HCY in the treatment group was significantly lower than that in the control group (P0.05). 6. The improvement of quality of life: compared with before treatment, PL,AS,AF,TS, in the treatment group and control group was significantly lower than that in the control group (P0.05). The DP score and the sum of the five scores were increased, the difference was statistically significant (P0.05). After treatment compared with the control group, the treatment group PL,AS,AF,TS,DP score and five scores and higher, the difference was statistically significant (P0.05). Conclusion: 1. Shenxiong Yixin decoction can improve the symptoms, symptoms and quality of life of patients with angina pectoris. 2. Shenxiong Yixin decoction can reduce the level of TC,LDL-C and homocysteine in patients.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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