当归芍药散加减联合儿黄散膜剂治疗宫颈HPV感染的临床观察

发布时间：2019-01-08 18:33

【摘要】：目的:观察当归芍药散加减联合儿黄散膜剂治疗宫颈HPV感染的临床疗效,为临床治疗宫颈HPV感染提供方法和思路。方法:本课题收集就诊于黑龙江中医药大学附属第一医院妇科门诊自2015年10月至2016年10月期间符合诊断标准的60例宫颈HPV感染的患者,将这些患者随机分为治疗组和对照组。治疗组30例,予中药汤剂当归芍药散加减口服联合儿黄散膜剂阴道置药,3个月经周期(一个疗程);对照组30例,予辛复宁阴道置药,3个月经周期(一个疗程)。观察两组病例中医临床证候积分的改变、HPVDNA病毒载量的改变,并通过治疗前后自身对比和两组间的对照对其进行疗效分析。结果:1、中药汤剂当归芍药散加减联合儿黄散膜剂能明显改善患者中医临床症候积分(p0.01),总有效率为90%,共30例,痊愈率36.7%,显效率43.3%,有效3%,无效3%,优于辛复宁的对照组:总有效率为56.7%,痊愈率6.7%,显效率40%,有效率3%,无效率43.3%。2、中药汤剂当归芍药散加减联合儿黄散膜剂在降低患者HPVDNA病毒载量方面有显著统计学差异(P0.01),明显优于对照组。3、治疗后治疗组30例中有20例转阴,转阴率为66.7%,对照组30例中12例转阴,HPV转阴率为40%,两组HPV转阴率的比较有显著统计学差异(P0.05)。4、治疗后对照组总有效率56.7%;治疗组总有效率90.0%。两组总有效率的比较有显著统计学差异(P0.01)。结论:1、当归芍药散加减联合儿黄散膜剂治疗宫颈HPV感染,能明显改善患者的中医临床症候,降低HPVDNA病毒载量,提高HPV的转阴率,临床疗效确切,且安全可靠,值得推广应用。
[Abstract]:Objective: to observe the clinical effect of Danggui Shaoyao Powder (Danggui Shaoyao Powder) combined with er Huang San (er Huang San) in the treatment of cervical HPV infection, and to provide methods and ideas for clinical treatment of cervix HPV infection. Methods: from October 2015 to October 2016, 60 patients with cervical HPV infection in gynecological outpatient department of the first affiliated Hospital of Heilongjiang University of traditional Chinese Medicine were collected and randomly divided into treatment group and control group. The treatment group (30 cases) was treated with traditional Chinese medicine decoction Danggui Shaoyao Powder plus or minus orally combined with er Huang San film vaginal placement for 3 menstrual cycles (one course of treatment) while the control group (30 cases) were given Xinfuning vaginal insertion medicine for 3 menstrual cycles (one course of treatment). The changes of TCM syndromes integral and HPVDNA viral load were observed in the two groups, and the therapeutic effects were analyzed by self-comparison before and after treatment and control between the two groups. Results: 1. Traditional Chinese medicine decoction Danggui Shaoyao Powder plus or minus combined with er Huang San could obviously improve the clinical symptom score of TCM (p0.01), the total effective rate was 90 cases (30 cases), the cure rate was 36.7%, the effective rate was 43.3%, and the effective rate was 33.3%. The total effective rate was 56.7, the recovery rate was 6.7, the effective rate was 40, the effective rate was 3percent, and the inefficiency was 43.33.2, the total effective rate was 56.7, the recovery rate was 6.7 percent, the effective rate was 40, the effective rate was 3percent, and the inefficiency was 43.3percent. Traditional Chinese medicine decoction Danggui Shaoyao Powder plus or minus combined with er Huang San film had significant difference in reducing the viral load of HPVDNA in patients (P0.01), which was obviously superior to the control group. 3. After treatment, 20 of 30 cases in the treatment group turned negative. The negative rate was 66.7%, 12 cases turned negative and 40% HPV turned negative in 30 cases in the control group. There was significant difference between the two groups in the negative conversion rate of HPV (P0.05). 4. The total effective rate of the control group was 56.7% after treatment. The total effective rate of the treatment group was 90.0%. There was a significant difference in the total effective rate between the two groups (P 0.01). Conclusion: 1.Danggui Shaoyao Powder plus or minus combined with er Huang San in the treatment of cervical HPV infection can significantly improve the clinical symptoms of patients with HPVDNA, reduce the load of HPVDNA virus, increase the negative rate of HPV, the clinical efficacy is accurate, and safe and reliable. It is worth popularizing and applying.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R271.9

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