益肾清利活血法对肾虚湿瘀蛋白尿患者尿足细胞排泄的影响

发布时间：2019-01-26 15:36

【摘要】：目的观察益肾清利活血法对肾虚湿瘀蛋白尿患者尿足细胞排泄的影响。方法收集2011年7月~2015年7月潍坊市益都中心医院肾内科收治的肾虚湿瘀蛋白尿患者100例,按奇偶数将其随机分为益肾组和对照组,各50例。对照组采用常规治疗,益肾组在常规治疗的基础上采用肾清利活血法治疗,疗程15个月。采集患者治疗前后24 h尿蛋白定量、尿足细胞排泄、中医症状积分、安全性等指标,进行分析。结果治疗前两组患者尿足细胞数量、24 h尿蛋白、症状积分比较,差异无统计学意义(P0.05)。治疗后益肾组尿足细胞数量、24 h尿蛋白量、症状积分均较治疗前显著降低,差异有高度统计学意义(P0.01),且益肾组治疗后尿足细胞数量、24 h尿蛋白量、中医症状积分均显著低于对照组,差异均有统计学意义(P0.05)。两组治疗后红细胞、白细胞、血小板、白蛋白、谷丙转氨酶比较,差异均无统计学意义(P0.05)。结论益肾清利活血法可能是通过保护肾脏足细胞达到降低肾虚湿瘀蛋白尿患者尿蛋白的作用。益肾清利活血法可以明显改善患者临床症状,安全性较好,没有明显不良反应。
[Abstract]:Objective to observe the effect of Yishen Qingli Huoxue method on urinary podocyte excretion in patients with kidney deficiency and dampness stasis proteinuria. Methods from July 2011 to July 2015, 100 patients with kidney deficiency and dampness stasis proteinuria were collected and randomly divided into kidney tonifying group and control group. The control group was treated with routine therapy, and the kidney tonifying group was treated with the method of kidney clearing and activating blood circulation on the basis of routine treatment for 15 months. 24 h urine protein, urine podocyte excretion, TCM symptom score and safety were collected before and after treatment. Results before treatment, there was no significant difference in the number of urinary podocytes, 24 h urine protein and symptom score between the two groups (P0.05). After treatment, the number of urinary podocytes, 24 h urine protein content and symptom score in kidney tonifying group were significantly lower than those before treatment (P0.01), and the quantity of urinary podocyte and 24 h urinary protein in tonifying kidney group were significantly lower than those before treatment (P0.01). TCM symptom scores were significantly lower than the control group, the differences were statistically significant (P0.05). There was no significant difference in erythrocyte, white blood cell, platelet, albumin and alanine aminotransferase between the two groups after treatment (P0.05). Conclusion Yishen Qingli Huoxue method may protect kidney podocytes to reduce urine protein in patients with kidney deficiency and dampness stasis proteinuria. Yishen Qingli Huoxue method can significantly improve the clinical symptoms of patients, the safety is good, there is no obvious adverse reactions.
【作者单位】：山东省潍坊市益都中心医院肾脏内科;江苏省中医院肾脏内科;
【基金】：山东省中医药科技发展计划项目(2011-279)
【分类号】：R277.5

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