双宝煎剂对先兆流产患者内分泌及细胞因子的影响

发布时间：2019-02-11 11:14

【摘要】：目的:通过观察双宝煎剂对血清孕酮(progestone,P),β-人绒毛膜促性腺激素(human chorionic gonadotropin,β-HCG),细胞因子γ-干扰素(interferon-γ,INF-γ),白细胞介素(IL)-2,IL-4,IL~(-1)0含量的影响,以及治疗先兆流产的临床疗效,探讨双宝煎剂对患者内分泌及细胞因子的影响,从母胎免疫调控及内分泌角度探讨双宝煎剂的安胎机制。方法:采用随机对照研究方法,以2013年4月—2013年11月在河南省中医院妇科门诊就诊的患者为研究对象,按照纳入、排除标准共纳入140例确诊为先兆流产的患者,采用SAS 8.2统计软件产生的随机分组表,将140例患者随机分为两组,中药组(70例),西药组(70例)。中药组给予双宝煎剂量口服,西药组给予口服地屈孕酮和肌注HCG针。采用化学发光酶免疫分析法检测P,β-HCG的浓度;采用酶联免疫吸附试验(Enzyme-linked immunosorbent assay,ELISA)法检测血清中细胞因子INF-γ,IL-2,IL-4,IL~(-1)0的浓度。结果:中药组血清中P,β-HCG含量明显高于西药组(P0.05);与西药组比较,中药组血清中IL-4,IL~(-1)0含量明显升高(P0.05),INF-γ,IL-2含量明显下降(P0.05)。结论:双宝煎剂能明显改善先兆流产患者内分泌激素及细胞因子的水平,极大地提高了保胎成功率,进一步论证了固肾安胎是中医治疗先兆流产的大法。
[Abstract]:Objective: to observe the effects of Shuangbao decoction on serum progesterone (progestone,P), 尾 -human chorionic gonadotropin (human chorionic gonadotropin, 尾 HCG), cytokine interferon- 纬 (INF- 纬) and interleukin-( IL) 2 (IL-4). The effect of IL~ (-1) 0 content and the clinical effect on threatened abortion were discussed. The effects of Shuangbao decoction on endocrine and cytokines of patients were discussed. The mechanism of antifetal effect of Shuangbao decoction was discussed from the point of view of maternal and fetal immune regulation and endocrine. Methods: a randomized controlled study was conducted with 140 patients diagnosed as threatened abortion from April 2013 to November 2013 in the gynecological outpatient department of Henan traditional Chinese Medicine Hospital. 140 patients were randomly divided into two groups by SAS 8.2 statistical software: traditional Chinese medicine group (70 cases) and western medicine group (70 cases). The traditional Chinese medicine group was given Shuangbao decoction orally, and the western medicine group was given the oral diproprogesterone and intramuscular injection of HCG. The concentration of P, 尾-HCG was detected by chemiluminescence enzyme immunoassay, and the concentrations of cytokines INF- 纬 and IL-2,IL-4,IL~ (-1) 0 in serum were detected by enzyme linked immunosorbent assay (Enzyme-linked immunosorbent assay,ELISA). Results: the levels of serum P, 尾-HCG in the Chinese medicine group were significantly higher than those in the western medicine group (P0.05). Compared with the western medicine group, the serum IL-4,IL~ (-1) 0 content of the traditional Chinese medicine group increased significantly (P0.05), the content of INF- 纬, IL-2 decreased significantly (P0.05). Conclusion: Shuangbao decoction can obviously improve the levels of endocrine hormones and cytokines in patients with threatened abortion and greatly improve the success rate of fetal preservation.
【作者单位】：河南省中医院;北京中医药大学;睢县中医院;
【基金】：河南省中医药科学研究专项(2013ZY02058))
【分类号】：R271.9

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