益气祛瘀饮治疗慢性心力衰竭气虚血瘀证的临床研究
发布时间：2019-02-13 20:11
【摘要】：目的:观察益气祛瘀饮对慢性心力衰竭气虚血瘀证治疗的临床疗效,并从中、西医两方面初步探究、讨论其作用机理。方法:将符合诊断与纳入标准的60例病例随机分为治疗组和对照组各30例,对照组给予西医标准治疗,治疗组在西医标准治疗基础上加用中药益气祛瘀饮,均治疗28天,记录患者治疗前后心功能NYHA分级、氨基末端脑纳素前体(NT-proBNP)、左室射血分数(LVEF)、6分钟步行距离和中医证候积分疗效,并采用SPSS17.0进行统计学分析。成果:治疗组心功能改善总有效率为100%,与对照组总有效率80%相比,有显著差异(P0.05)。两组血清NT-proBNP均有非常显著下降(P0.01),但治疗组治疗后NT-proBNP的值明显低于对照组(P0.01),两组LVEF和6分钟步行试验距离均有非常显著上升(P0.01),且治疗组改善幅度明显高于对照组(P0.05)。对中医评价指标的比较中,中医证候总积分治疗组疗效明显优于对照组(P0.05),单个症状评分疗效治疗组也优于对照组,且除口干P0.05外,其余差异均有统计学意义。结论:益气祛瘀饮联合西药标准治疗慢性心力衰竭气虚血瘀证,对于改善患者心功能,和改善无论总体还是单个中医症状改善均较单用西药治疗有显著作用。
[Abstract]:Objective: to observe the clinical effect of Yiqi Quyu decoction on qi deficiency and blood stasis syndrome of chronic heart failure and discuss its mechanism. Methods: sixty patients who met the criteria of diagnosis and inclusion were randomly divided into treatment group (n = 30) and control group (n = 30). The control group was treated with western medicine standard therapy. The treatment group was treated with traditional Chinese medicine Yiqi Quyu decoction on the basis of western medicine standard treatment for 28 days. The NYHA classification of cardiac function, amino-terminal nana precursor (NT-proBNP), 6-minute walking distance of left ventricular ejection fraction (LVEF),) and the curative effect of TCM syndromes were recorded before and after treatment. The results were statistically analyzed by SPSS17.0. Results: the total effective rate of heart function improvement in the treatment group was 100%, which was significantly different from that in the control group (80%) (P0.05). Serum NT-proBNP decreased significantly in both groups (P0.01), but the value of NT-proBNP in the treatment group was significantly lower than that in the control group (P0.01). The distance of LVEF and 6-minute walking test was significantly increased in both groups (P0.01). The improvement of the treatment group was significantly higher than that of the control group (P0.05). In the comparison of TCM evaluation indexes, the curative effect of the treatment group was significantly better than that of the control group (P0.05), the treatment group of single symptom score was also superior to the control group, and the other differences were statistically significant except for the dry mouth P0.05. Conclusion: the combination of Yiqi Quyu Yin and western medicine standard in the treatment of chronic heart failure syndrome of qi deficiency and blood stasis has a significant effect on improving the heart function of patients and improving the symptoms of both general and individual Chinese medicine.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
本文编号：2421823
[Abstract]:Objective: to observe the clinical effect of Yiqi Quyu decoction on qi deficiency and blood stasis syndrome of chronic heart failure and discuss its mechanism. Methods: sixty patients who met the criteria of diagnosis and inclusion were randomly divided into treatment group (n = 30) and control group (n = 30). The control group was treated with western medicine standard therapy. The treatment group was treated with traditional Chinese medicine Yiqi Quyu decoction on the basis of western medicine standard treatment for 28 days. The NYHA classification of cardiac function, amino-terminal nana precursor (NT-proBNP), 6-minute walking distance of left ventricular ejection fraction (LVEF),) and the curative effect of TCM syndromes were recorded before and after treatment. The results were statistically analyzed by SPSS17.0. Results: the total effective rate of heart function improvement in the treatment group was 100%, which was significantly different from that in the control group (80%) (P0.05). Serum NT-proBNP decreased significantly in both groups (P0.01), but the value of NT-proBNP in the treatment group was significantly lower than that in the control group (P0.01). The distance of LVEF and 6-minute walking test was significantly increased in both groups (P0.01). The improvement of the treatment group was significantly higher than that of the control group (P0.05). In the comparison of TCM evaluation indexes, the curative effect of the treatment group was significantly better than that of the control group (P0.05), the treatment group of single symptom score was also superior to the control group, and the other differences were statistically significant except for the dry mouth P0.05. Conclusion: the combination of Yiqi Quyu Yin and western medicine standard in the treatment of chronic heart failure syndrome of qi deficiency and blood stasis has a significant effect on improving the heart function of patients and improving the symptoms of both general and individual Chinese medicine.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
【参考文献】
相关期刊论文 前10条
1 张建平;张淼;王焕玲;张红霞;;田芬兰对心脾相关的认识[J];河南中医;2015年01期
2 张晓华;刘淑荣;尹雪;;心力衰竭中医病机及证候演变研究进展[J];中国中医急症;2013年10期
3 吴伟;刘勇;赵英强;;心衰作为心力衰竭的中医病名探究[J];中医杂志;2013年10期
4 邱雅慧;薛凌;高夏青;;丹参多酚酸盐对慢性心力衰竭患者心功能及炎症因子的影响[J];中国实验方剂学杂志;2013年07期
5 农祥兵;;慢性心力衰竭的治疗进展[J];实用心脑肺血管病杂志;2013年03期
6 袁国强;李彦霞;魏聪;;从脉络学说论治慢性心力衰竭[J];中国中医基础医学杂志;2012年08期
7 李庆洋;;慢性心力衰竭的药物治疗进展及其现状[J];实用心脑肺血管病杂志;2012年06期
8 张云;王阶;吴广均;刘瑞华;;丹参酚酸B抑制TLR4-NFκB-TNFα炎症损伤通路防治心肌细胞的缺氧损伤[J];辽宁中医杂志;2012年01期
9 安芳;王林;黄姣红;杨艳华;李广平;马金萍;;利尿剂对慢性心力衰竭住院患者预后影响的回顾性分析[J];天津医药;2009年01期
10 刘柏年;殷雅琴;;醛固酮受体拮抗剂治疗慢性心力衰竭[J];医学综述;2008年13期
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