非缓解期Graves病患者中医体质分布规律及多因素相关性分析

发布时间：2019-02-19 18:24

【摘要】：目的:研究非缓解期Graves病患者与正常人的中医体质分布规律,以期在未出现Graves病时,发现Graves病的高危体质,调整失衡的体质,以避免或者减少Graves病和相关并发症的发生。方法:甲亢组纳入非缓解期Graves病患者共300例,正常组纳入正常人102例,分别填写甲亢体质调查表及正常人体质调查表,通过体质调查表来判定的体质类型,并且记录受试者的一般情况、患病情况、甲状腺功能。研究非缓解期Graves病患者、正常人体质分布规律,以及体质与患者甲状腺肿大程度、突眼、粒细胞减少、甲亢肝损害、甲状腺激素、甲状腺相关抗体之间是否有相关关系。结果:1.正常人组,平和质出现频次最多(43.6%);气虚质其次(13.9%);甲亢组,气虚质出现频次最多(23.8%);阴虚质其次(17.6%);平和质(13.2%);气郁质(12.1%),两组的体质类型分布具有显著性差异(χ2=96.38,P0.001)。2.甲亢患者中,单一体质106例(35.3%),复合体质194例(64.7%),以复合体质为主。甲亢发病率女性高于男性,男:女为1:2.48,年龄分布在21~30岁之间的最多,高发年龄为20~50岁。3.正常人组与甲亢初发组、治疗后病程2年组、治疗后病程≥2年组体质频次之间的差异均有统计学意义(p0.001);体质甲亢初发组、治疗后病程2年组、治疗后病程≥2年组三者体质频次之间的差异无统计学意义(p0.05)。4.突眼组和无突眼组体质频次之间的差异有显著的统计学意义(p0.01),甲状腺肿大Ⅱ度组和≥Ⅱ度组、粒细胞减少组和无粒细胞减少组、肝损害组和无肝损害组体质频次之间的差异无统计学意义(p0.05),TGAb、TRAb、TMAb各分段组的体质频次之间的差异无统计学意义(p0.05)。5.向前逐步法logistic回归分析:年龄与气虚质成正相关(P0.05,OR值为1.023;95%C.I:1.003-1.004),突眼与阴虚质成正相关(P0.05,OR值为2.068;95%C.I:1.114-3.838),甲状腺肿大与气郁质成正相关(P0.05,OR值为1.843;95%C.I:1.015-3.349)。结论:1.正常组,平和质最多、气虚质次之;甲亢组主要体质为气虚质、阴虚质、气郁质、平和质,以兼夹体质为主,两组的体质分布不同。2.非缓解期Graves病发病率女性高于男性,年龄分布在21~30岁之间的最多,高发年龄为20~50岁。3.年龄与气虚质成正相关,突眼与阴虚质成正相关,甲状腺肿大与气郁质成正相关。
[Abstract]:Objective: to study the distribution of TCM physique in patients with non-remission Graves's disease and normal people in order to find the high risk constitution of Graves disease and adjust the unbalanced constitution in order to avoid or reduce the occurrence of Graves disease and related complications. Methods: a total of 300 patients with non-remission Graves's disease were included in the hyperthyroidism group and 102 normal persons were included in the normal group. The general condition, illness and thyroid function of the subjects were recorded. To study the distribution of constitution in patients with non-remission Graves's disease and the relationship between constitution and goitre degree, exophthalmos, granulocytosis, hyperthyroidism liver damage, thyroid hormone and thyroid-associated antibody. Results: 1. In the normal group, the frequency of calmness (43.6%), deficiency of qi (13.9%), hyperthyroidism (23.8%), deficiency of yin (17.6%), calmness (13.2%) were the most frequent. There was a significant difference in the distribution of physical types between the two groups (蠂 ~ (2) P ~ (96.38) P _ (0.001). Among the patients with hyperthyroidism, 106 (35.3%) had a single constitution and 194 (64.7%) had a compound constitution. The incidence of hyperthyroidism in women was higher than that in men (1: 2.48 for men). The most common age was between 21 and 30 years old, and the high incidence rate was 20 to 50 years old. There were significant differences in physical fitness frequency between the normal group and the hyperthyroidism group, the course of disease 2 years after treatment and the course 鈮，

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