基于聚类分析探讨姜良铎治疗肺间质纤维化用药规律

发布时间：2019-02-20 08:15

【摘要】：目的:探讨姜良铎教授治疗肺间质纤维化的常用药物和配伍规律。方法:以2003年3月至2015年8月在姜良铎教授门诊就诊的肺间质纤维化患者178例为研究对象,对姜良铎教授治疗肺间质纤维化常用药物进行聚类分析,探索其治疗肺间质纤维化的常用药物和配伍规律。结果:姜良铎教授治疗肺间质纤维化使用最多的药物为贝母、知母、瓜蒌、水蛭、海蛤壳、丹参。聚类分析显示常用药物可分为5类:宣肺泻热和疏肝清热类;清肺化痰和活血化瘀类;益气养阴和平喘类;平肝熄风和理气健脾类;益气养阴和清热凉血类。结论:姜良铎教授治疗肺间质纤维化用药注重调畅气机,于宣肺泻热中寓疏肝清热;调畅气机,未病先防,既病防变,于平肝熄风中寓理气健脾;攻补兼施,于益气养阴寓平喘、清热凉血;痰瘀并治,于清肺化痰中寓活血化瘀。
[Abstract]:Objective: to explore the common medicine and compatibility of Professor Jiang Liangduo in the treatment of pulmonary interstitial fibrosis. Methods: 178 patients with pulmonary interstitial fibrosis treated by Professor Jiang Liangduo from March 2003 to August 2015 were enrolled in the study. The common drugs used in the treatment of pulmonary interstitial fibrosis by Professor Jiang Liangduo were analyzed by cluster analysis. Objective: to explore the common drugs and compatibility in the treatment of pulmonary interstitial fibrosis. Results: professor Jiang Liangduo used most medicine to treat pulmonary interstitial fibrosis: Fritillaria, Anemarrhena, Trichosanthes, Leech, Sea clam shell, Salvia miltiorrhiza. Cluster analysis showed that the common drugs can be divided into five categories: purging the lung and purging heat and soothing the liver and clearing away heat; clearing the lung and resolving phlegm and activating blood circulation; supplementing qi and nourishing yin and relieving asthma; calming the liver and dispelling wind and regulating qi and invigorating spleen; benefiting qi and nourishing yin and clearing away heat and cooling blood. Conclusion: professor Jiang Liangduo's treatment of pulmonary interstitial fibrosis focuses on regulating qi-regulating machine, regulating liver and clearing heat in purging heat of the lung, regulating qi-regulating machine, preventing the disease before illness, regulating qi and invigorating spleen in calming the liver and quashing the wind; Both attack and tonifying, invigorating qi and yin, relieving asthma, clearing heat and cooling blood, treating phlegm and blood stasis, promoting blood circulation and removing blood stasis in clearing lung and resolving phlegm.
【作者单位】：北京中医药大学第三附属医院;北京中医药大学东方医院;北京中医药大学东直门医院;
【基金】：北京中医药大学自主选题项目(No.2015-JYB-JSMS150)~~
【分类号】：R249;R259

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