温痹汤治疗寒湿痹阻型类风湿关节炎的临床疗效研究

发布时间：2019-03-07 10:36

【摘要】：目的:通过观察温痹汤联合西药治疗寒湿痹阻型类风湿关节炎的有效性及安全性,为温痹汤治疗寒湿痹阻型RA在临床上提供理论依据。方法:将符合要求的60例患者按照就诊顺序随机分为两组,治疗组30例,对照组30例,分别进行12周的治疗观察。治疗期间两组同时给予口服甲氨蝶呤10mg~15mg,每周1次,双氯芬酸钠缓释片75mg,每日1次。治疗组在西药基础上给予温痹汤口服。观察并记录两组患者治疗前后的临床症状和体征,血沉(ESR)、C反应蛋白(CRP)、中医证候积分、DAS28评分等疗效指标,同时观察谷丙转氨酶、谷草转氨酶、尿素氮、肌酐等安全性指标,并用SPSS18.0统计软件进行统计分析,以评价温痹汤的临床疗效及安全性。结果:1.本研究共纳入60例RA患者,最终完成59例,包括观察组30例和对照组29例。2.治疗后两组患者的关节肿胀数、关节压痛数、CRP、ESR、DAS28评分、中医证候积分较治疗前均明显下降,治疗组结果优于对照组。两组组内及组间对比具有统计学意义(P0.05)。3.两组在治疗过程中,不良反应的发生,治疗组略低于对照组,但差异无明显统计学意义(P0.05)。结论:温痹汤联合西药治疗寒湿痹阻型RA有较好的临床疗效,且安全性高。
[Abstract]:Aim: to observe the efficacy and safety of Wenbi decoction combined with western medicine in treating rheumatoid arthritis of cold-dampness arthralgia type, so as to provide a theoretical basis for the treatment of RA with cold-damp arthralgia type by Wenbi decoction. Methods: 60 patients were randomly divided into two groups: treatment group (n = 30) and control group (n = 30). During the treatment, both groups were given methotrexate 10 mg and 15 mg orally once a week, and diclofenac sodium sustained-release tablets 75 mg, once a day. The treatment group was given Wenbi decoction orally on the basis of western medicine. To observe and record the clinical symptoms and signs of the two groups before and after treatment, the TCM syndrome integral of erythrocyte sedimentation rate (ESR), C reactive protein (CRP), the DAS28 score and so on. At the same time, the effects of glutamic pyruvic transaminase, glutamic oxaloacetic transaminase and urea nitrogen were observed. The clinical efficacy and safety of Wenbi decoction were evaluated by using SPSS18.0 software to evaluate the clinical efficacy and safety of Wenbi decoction. Results: 1. A total of 60 patients with RA were enrolled in this study, and 59 patients were finally completed, including 30 patients in the observation group and 29 patients in the control group. After treatment, the number of joint swelling, the number of joint tenderness, the score of CRP,ESR,DAS28 and the score of TCM syndrome were significantly decreased in the two groups. The result of the treatment group was better than that of the control group. The intra-and inter-group comparison between the two groups was statistically significant (P0.05). 3. In the treatment process, the incidence of adverse reactions in the treatment group was slightly lower than that in the control group, but there was no significant difference (P0.05). Conclusion: Wenbi decoction combined with western medicine has good clinical effect and high safety in the treatment of cold-dampness arthralgia type RA.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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