观察电针手少阴心经穴前后不同状态静息态功能磁共振脑功能连接的变化

发布时间：2019-03-15 12:02

【摘要】：目的:观察电针心经穴前后3种状态(静息态、电针刺激态、拔针后效应态)脑功能连接的变化,为电针心经穴的中枢响应机制提供影像学依据。方法:选取符合纳入标准的健康受试者14名,采用静息态功能磁共振,获得电针心经穴前后3种状态的脑功能连接并分析其差异。结果:(1)静息状态下与双侧后扣带回存在功能连接的脑区有双侧小脑、额下回,左侧额中回、颞下回、楔前叶、枕中回及枕叶舌回,右侧中央前回、顶下小叶、海马旁回(P0.05)。(2)与静息态比较,电针刺激态与拔针后效应态均出现脑内功能连接增强、负激活及新激活脑区。(3)与拔针后效应态比较,电针刺激态出现脑内功能连接增强和负激活脑区。结论:(1)大脑在清醒、安静的无任务状态下存在一定的功能活动。(2)电针心经穴前后脑区有不同的中枢响应效应,提示心经穴发挥作用可能是通过激活某些特定脑区实现的,但其中枢调控的特异性还有待进一步研究。(3)电针对脑活动的影响不仅存在即刻效应,还有后续效应,电针刺激及其后续效应可能是通过影响神经网络而发挥临床作用的。
[Abstract]:Aim: to observe the changes of brain functional connection in three states before and after electroacupuncture (resting state, electroacupuncture stimulating state and post-extraction effect state), so as to provide imaging basis for the central response mechanism of electroacupuncture at Xinmeridian acupoints. Methods: 14 healthy subjects who met the inclusion criteria were selected and their brain functional connections before and after electroacupuncture at the heart meridian were obtained by resting functional magnetic resonance imaging (FMRI) and their differences were analyzed. Results: (1) there were bilateral cerebellum, inferior frontal gyrus, left middle frontal gyrus, inferior temporal gyrus, anterior wedge lobe, middle occipital gyrus and occipital lobe tongue gyrus, right anterior central gyrus and inferior parietal lobule in resting state, and there were bilateral cerebellum, inferior frontal gyrus, left middle frontal gyrus, middle occipital gyrus and occipital lobule gyrus. Compared with resting state (P0.05). (- 2), the functional connection in the brain was enhanced in both the electroacupuncture-stimulated state and the effective state after the needle extraction. (3) compared with the post-acupuncture effect state, there was a negative activation and a new activation of the brain area. (3) compared with the post-acupuncture effect state, there was no significant difference between the two groups. The brain functional connection was enhanced and the brain area was negatively activated by electroacupuncture stimulation. Conclusion: (1) there are certain functional activities of the brain in the awake and quiet state. (2) there are different central response effects in the brain area before and after the acupuncture of the heart meridian. It is suggested that the action of Xinjing acupoints may be achieved by activating some specific brain areas, but the specificity of central regulation needs to be further studied. (3) the effect of electroacupuncture on brain activity has not only immediate effect, but also follow-up effect. Electro-acupuncture stimulation and its follow-up effects may play a clinical role through the influence of neural networks.
【作者单位】：湖南中医药大学第一附属医院;
【基金】：国家自然科学基金项目(No.81273861) 湖南省中医药科研计划项目(No.2016105) 湖南省教育厅科学研究项目(No.13C696) 湖南省自然科学基金项目(No.11JJ5078)~~
【分类号】：R246

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