基于心气虚立论大补心汤治疗慢性紧张型头痛的临床研究

发布时间：2019-03-21 17:34

【摘要】：目的：本研究的目的在于从心气虚立论,观察大补心汤治疗慢性紧张型头痛的临床疗效,分析其作用机制,拓宽治疗慢性紧张型头痛的思路。方法：采用随机对照的研究方法,将2015年1月至2015年12月就诊于山东中医药大学附属医院脑病科门诊及病房的符合纳入标准的66例心气虚型慢性紧张型头痛患者随机分为两组,试验组33例,予大补心汤加减治疗；对照组33例,予清脑复神液治疗,疗程均为4周。观察两组患者治疗前后头痛指数积分及中医症候评分的变化,并观察治疗过程中出现的不良反应,采用SPSS17.0统计软件进行统计学分析,评定两种治疗方式的临床疗效及安全性。结果：1.头痛指数疗效：经过治疗4周后,试验组总有效率为96.77%,对照组总有效率为93.75%,两组患者治疗后头痛指数疗效组间比较P0.05,无统计学意义；但治疗后,两组患者在头痛程度(P=0.0020.01)、头痛指数(P=0.0180.05)方面组间比较具有统计学意义,试验组明显优于对照组。2.中医证候疗效：治疗前后对比,试验组中医证候评分总有效率为96.77%,对照组中医证候评分总有效率为90.63%,两组患者治疗后中医证候组间比较P0.01,具有显著统计学意义。而且,治疗后,两组患者在纳差嗳气(P=0.0000.01)、惊悸怔忡(P=0.0330.05)方面组间比较具有统计学意义,试验组明显优于对照组。3.安全性分析：治疗期间,两组患者均未出现不良反应和毒副作用,安全性较好。结论：大补心汤可以显著改善心气虚型慢性紧张型头痛患者的头痛程度、发作次数及疼痛持续时间,并能有效缓解中医证候,疗效确切,且用药期间无毒副作用。证明大补心汤组方严谨,对于临床心气虚型慢性紧张型头痛具有较好的疗效。同时,也说明从心气虚立论是治疗慢性紧张型头痛的重要研究思路。
[Abstract]:Aim: the aim of this study is to observe the clinical effect of Dabuxin decoction on chronic tension type headache from the viewpoint of deficiency of heart qi, analyze its action mechanism, and widen the train of thought of treating chronic tension type headache. Methods: from January 2015 to December 2015, 66 patients with chronic tension headache of heart qi deficiency type were randomly divided into two groups, who were admitted to the outpatient department and ward of the affiliated Hospital of Shandong University of traditional Chinese Medicine from January 2015 to December 2015, and 66 patients with chronic tension headache of heart qi deficiency type were randomly divided into two groups. 33 cases in the test group were treated with Dabuxin decoction. 33 cases in control group were treated with Qingnao Fushen liquid for 4 weeks. To observe the changes of headache index score and TCM symptom score before and after treatment in the two groups, and to observe the adverse reactions in the course of treatment. SPSS17.0 statistical software was used for statistical analysis. To evaluate the clinical efficacy and safety of the two treatments. Results: 1. After 4 weeks of treatment, the total effective rate was 96.77% in the test group and 93.75% in the control group. There was no statistical significance between the two groups in the efficacy of headache index after treatment. However, after treatment, there was significant difference in headache degree (P = 0.0020.01) and headache index (P < 0.0180.05) between the two groups, and that of the experimental group was significantly better than that of the control group. 2. The total effective rate of TCM syndrome score was 96.77% in the test group and 90.63% in the control group before and after treatment. After treatment, the total effective rate of TCM syndrome score between the two groups was compared with that of the two groups (P 0.01, P < 0.01), and the total effective rate of TCM syndrome score in the control group was 96.77%. There was significant statistical significance. Moreover, after treatment, there was significant difference between the two groups in belching (P < 0.0000.01) and palpitation (P < 0.0330.05). The experimental group was significantly better than the control group in terms of belching (P = 0.0000.01) and palpitation (P = 0.0330.05). Safety analysis: during the treatment, there were no adverse reactions and side effects in both groups, and the safety was better. Conclusion: Dabuxin decoction can significantly improve the degree of headache, frequency of onset and duration of pain in patients with chronic tension headache of heart qi deficiency type, and can effectively relieve the syndrome of traditional Chinese medicine with definite curative effect and no toxic and side effects during the use of the medicine. It is proved that the prescription of Dabuxin decoction is strict and has a good curative effect on clinical chronic tension headache of heart qi deficiency type. At the same time, it also shows that the theory of deficiency of heart qi is an important research way to treat chronic tension headache.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R277.7

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