基于“先开导后补益论”治疗视网膜静脉阻塞（气滞血瘀证）的临床观察

发布时间：2019-03-23 18:08

【摘要】：研究目的:观察基于“先开导后补益论”中药治疗视网膜静脉阻塞(气滞血瘀证)的有效性和安全性。研究方法:将44例(44只眼)视网膜静脉阻塞患者随机分为开导补益组和对照组。开导补益组和对照组的年龄、性别组成和治疗前视力分布的比较上均无统计学差异(PO.05),开导补益组和对照组具有可比性。开导补益组(23只眼)根据“先开导后补益论”将治疗分为开导期和补益期,开导期予以血府逐瘀汤为主方口服开瘀导滞,并根据患者病情进行加减;补益期予以补中益气汤为主方扶正祛邪,并根据患者病情进行加减。对照组(21只眼)始终予以血府逐瘀汤为主方口服。开导补益组和对照组需每周复诊1次,治疗2个疗程后,比较开导补益组和对照组治疗前后眼底出血情况、最佳矫正视力和视网膜循环时间的改变等。结果:对照组治疗视网膜静脉阻塞的总有效率为66.67%,开导补益组治疗视网膜静脉阻塞的总有效率为86.95%,差异具有统计学意义((PO.O5),在提高中心视力、促进眼底出血吸收和改善视网膜循环时间方面,两组均有疗效,且开导补益组的疗效明显优于对照组,其差异有统计学意义((PO.O5)。结论:基于“先开导后补益论”治疗视网膜静脉阻塞(气滞血瘀证)疗效确切,且无明显的副作用。
[Abstract]:Objective: to observe the efficacy and safety of traditional Chinese medicine (TCM) in the treatment of retinal vein occlusion (syndrome of qi stagnation and blood stasis). Methods: 44 patients (44 eyes) with retinal vein occlusion were randomly divided into two groups. There was no significant difference in age, sex composition and visual acuity distribution before treatment between the two groups (PO.05), but there was comparability between the enlightened supplement group and the control group. The group (23 eyes) divided the treatment into open stage and replenishment period according to the theory of "guiding first and then replenishing". The patients were treated with Xuefu Zhuyu decoction (Xuefu Zhuyu decoction) as the main prescription, and were added and subtracted according to the patient's condition. Tonifying period to Buzhong Yiqi decoction as the main side to strengthen and dispel evil, and according to the patient's condition to add and subtract. The control group (21 eyes) was always given Xuefu Zhuyu decoction as the main oral prescription. After 2 courses of treatment, the fundus hemorrhage, the best corrected visual acuity and the change of retinal circulation time before and after treatment were compared between the two groups. Results: the total effective rate of retinal vein occlusion was 66.67% in the control group and 86.95% in the enlightening and supplementing group. The difference was statistically significant (PO.O5) in improving the central visual acuity. In terms of promoting the absorption of fundus hemorrhage and improving the time of retinal circulation, the curative effect of both groups was better than that of the control group, and the difference was statistically significant (PO.O5). Conclusion: the treatment of retinal vein occlusion (syndrome of qi stagnation and blood stasis) is effective based on the theory of "opening guidance first and replenishing benefits", and there are no obvious side effects.
【学位授予单位】：长春中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R276.7

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