寻常型银屑病中医辨治新体系对患者生活质量影响的研究

发布时间：2019-03-23 17:26

【摘要】：目的:对比研究刘爱民教授提出的寻常型银屑病中医辨治新体系和“血热”、“血燥”、“血瘀”经典体系对患者生活质量的影响,从生活质量层面比较两者的差异,评估寻常型银屑病治疗效果,为临床选择合理有效的治疗方案提供科学有力的依据。方法:(1)本研究采用随机对照的方式,将符合纳入标准的病例随机分为寻常型银屑病中医辨治新体系治疗组和经典体系对照组,并对每一个初诊病例建立病历观察表。(2)中医辨治新体系治疗组(150例):严格根据新体系进行辨证用药;经典体系对照组(150例):严格依据经典体系进行辨证用药。所有纳入的患者每治疗2周为一个疗程,以治疗8周或PASI积分减少≥95%为治疗终点。(3)观察指标:分别观察两组治疗前、治疗4周、治疗8周(或治愈时)的皮肤病生活质量指数(DLQI)评分、银屑病障碍指数(PDI)评分的变化。(4)统计方法:对治疗组和对照组的年龄、初诊时PASI得分以及治疗前、治疗4周、治疗8周(或治愈时)的DLQI评分、PDI评分采用独立样本t检验;性别、辨证分型比较采用χ2检验;分别对DLQI评分、PDI评分在4周-基线和8周-基线进行协方差分析。所有统计分析采用SPSS 18.0统计软件完成,以P≤0.05认为有统计学意义。结果:(1)一般资料结果分析:治疗组与对照组在性别、年龄、治疗前PASI积分、DLQI评分和PDI评分比较均无统计学意义,说明组间具有可比性;治疗组与对照组在证型分布构成比具有统计学差异,可通过协方差分析校正协变量对因变量的影响效应。(2)治疗4周和治疗8周(或治愈时)两组DLQI、PDI评分均低于治疗前评分,治疗组评分数值明显小于对照组,且治疗组评分降低幅度显著大于对照组。结论:寻常型银屑病中医辨治新体系和经典体系均能改善患者的生活质量,但以新体系治疗组对患者生活质量的改善程度更为明显,能有效降低DLQI和PDI评分,提升患者的生活质量,值得临床推广使用。
[Abstract]:Objective: to compare the effects of traditional Chinese Medicine (TCM) differentiation and treatment system and "Blood Heat", "Blood dryness" and "Blood stasis" proposed by Professor Liu Aimin on the quality of life of patients, and to compare the difference between the two systems in terms of quality of life. To evaluate the therapeutic effect of psoriasis vulgaris and to provide scientific and powerful basis for clinical selection of reasonable and effective treatment regimen. Methods: (1) the patients with psoriasis vulgaris were randomly divided into two groups: the traditional Chinese medicine treatment group (TCM treatment group) and the classical control group (control group). (2) traditional Chinese medicine treatment group (150 cases): strictly according to the new system of syndrome differentiation; Classic system control group (150 cases): strictly according to the classic system for syndrome differentiation. All the patients were treated for 2 weeks as a course of treatment, with 8 weeks of treatment or 95% reduction of PASI score as the end point of treatment. (3) observation indexes: the two groups were observed before treatment and 4 weeks after treatment. (4) Statistical methods: the age of the treatment group and the control group, the PASI score of the first visit and before the treatment, the changes of the (DLQI) score of the skin disease quality of life index and the (PDI) score of the psoriasis disorder index at the beginning of the treatment, and the change of the Psoriasis Disorder Index score before the treatment. 4 weeks of treatment, 8 weeks of treatment (or cure) of the DLQI score, PDI score using independent sample t test; 蠂 2 test was used to analyze the covariance of DLQI score and PDI score at 4 weeks to baseline and 8 weeks to baseline respectively. All statistical analysis was carried out by SPSS 18.0 statistical software. P 鈮，

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