冠心病合并糖尿病与单纯冠心病患者中药应用情况对比研究

发布时间：2019-03-25 08:58

【摘要】：1.研究目的通过回顾分析山东中医药大学附属医院第一诊断为冠心病的患者,对单纯冠心病与冠心病合并糖尿病患者的中药使用进行对比研究,分析糖尿病对冠心病患者中药使用的影响,为中医治疗冠心病及冠心病合并糖尿病提供用药思路。2.研究方法收集山东中医药大学附属医院2014年9月-2015年12月第一诊断为冠心病的住院病例,建立数据库,基于数据库运用Excel、SPSS等软件分析中药之间的关联程度,并比较研究单纯冠心病与冠心病合并糖尿病患者中药使用的异同。3.结果共搜集病例300例,涉及中药237味,经频数分析得出中药总频数4650。其中黄芪、白芍、党参、红花、三七粉等药在单纯冠心病患者中使用频数比冠心病合并糖尿病患者高,而川芎、瓜蒌、黄连、生地、黄芩、赤芍、槲寄生等药在冠心病合并糖尿病的患者中使用频数高于单纯冠心病患者。对于药物分类分析,补气药、化痰除湿药、理气药以及安神药在单纯冠心病患者中所占比例高于冠心病合并糖尿病患者,而冠心病合并糖尿病组以活血化瘀、清热养阴、解表药为主。经关联规则算法分析得到药物间有意义的关联规则489条,川芎是出现次数最多的药物,为152次,在冠心病组茯苓和白术配伍的支持度最高,瓜蒌、薤白、甘草配伍的置信度最高;冠心病合并糖尿病组,甘草、丹参配伍的支持度最高,麦冬、五味子、葛根配伍的置信度最高。4.结论通过本研究发现,治疗单纯冠心病以补气、化痰除湿的中药为主,常配伍补血、活血、理气、利水药,而治疗合并糖尿病的冠心病则多在活血化瘀、滋阴清热药的基础上配伍使用补气、化痰、解表药。
[Abstract]:1. Objective to analyze the first diagnosed patients with coronary heart disease in the affiliated Hospital of Shandong University of traditional Chinese Medicine, and to compare the use of traditional Chinese medicine in patients with simple coronary heart disease and coronary heart disease complicated with diabetes mellitus. To analyze the influence of diabetes on the use of traditional Chinese medicine in patients with coronary heart disease, and to provide the thinking of medication for treating coronary heart disease and coronary heart disease complicated with diabetes mellitus. Methods the hospitalized cases of coronary heart disease were collected from September 2014 to December 2015 in the affiliated Hospital of Shandong University of traditional Chinese Medicine, and the database was established. Based on the database, the degree of association between traditional Chinese medicine was analyzed by Excel,SPSS and other software. And compare the similarities and differences between simple coronary heart disease and coronary heart disease complicated with diabetes mellitus. 3. Results A total of 300 cases involving 237 herbs were collected. The total frequency of TCM was 4650 by frequency analysis. Among them, Astragalus membranaceus, Radix Paeoniae Alba, Radix Codonopsis, Safflower and Notoginseng Powder were used more frequently in patients with simple coronary heart disease than in patients with coronary heart disease complicated with diabetes. Mistletoe and other drugs were used more frequently in patients with coronary heart disease complicated with diabetes than in patients with simple coronary heart disease. For the classification analysis of drugs, the proportion of drugs for tonifying qi, removing dampness for phlegm and removing dampness, regulating qi and tranquilizing drugs in patients with simple coronary heart disease were higher than those with coronary heart disease complicated with diabetes mellitus. Antiepiphytic is the main antidote. Through the analysis of association rule algorithm, 489 meaningful association rules were obtained. Ligusticum Chuanxiong was the most frequently seen drug, which was 152 times. In the coronary heart disease group, Poria cocos and Atractylodes macrocephala had the highest support, Trichosanthes, Xiebai, etc. The confidence of Glycyrrhiza uralensis compatibility was the highest; The combination of Radix Glycyrrhizae and Salvia miltiorrhiza had the highest level of support, and the compatibility of Radix Ophiopogonis, Schisandra chinensis and Radix Puerariae had the highest confidence level. 4. Conclusion through this study, it is found that the treatment of simple coronary heart disease is mainly to replenish qi, remove phlegm and dehumidify dampness. It is often combined with blood invigorating, activating blood circulation, regulating qi and promoting water, while coronary heart disease with diabetes mellitus is mostly treated with activating blood circulation and removing blood stasis. Nourishing Yin and Clearing Heat on the basis of compatible use of tonifying qi, resolving phlegm, antisuperficial drugs.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

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