益气养阴、清热化痰活血法治疗不稳定型心绞痛的临床研究
发布时间：2019-04-04 13:51
【摘要】：目的:通过观察精灵方(益气养阴、清热化痰活血法)对不稳定型心绞痛患者中医症状、心绞痛有效率、心电图、血脂、血液流变学、炎症因子等指标的影响,评价"益气养阴、清热化痰活血法"治疗不稳定型心绞痛的临床疗效。方法:选择符合纳入标准的气阴两虚、痰热瘀阻型不稳定型心绞痛患者40例,采用随机分组的方法,分为治疗组20例,对照组20例。对照组给予西医规范化治疗,治疗组在对照组的基础上联合精灵方,两组均治疗8周。比较两组患者治疗前后中医症状积分疗效、心绞痛有效率、心电图、血脂、血液流变学、炎症因子等指标的变化情况,分析临床疗效。结果:(1)中医症状积分及疗效:治疗后两组中医症状积分均有显著改善(P0.05),治疗组总有效率90%,对照组总有效率60%,治疗组改善优于对照组(P0.05);(2)心绞痛有效率:治疗后两组心绞痛症状均有显著改善(P0.05),治疗组总有效率90%,对照组总有效率85%,治疗组与对照组无差异(P0.05);(3)心电图:治疗后两组心电图均有显著改善(P0.05),治疗组总有效率75%,对照组总有效率55%,治疗组与对照组无差异(P0.05);(4)血脂:治疗后两组TC、TG、LDL-c均显著降低(P0.05),治疗组优于对照组(P0.05);治疗后两组HDL-c均无显著升高(P0.05);(5)血液流变学:治疗后两组全血高切、中切、低切、血浆黏度及血沉均显著降低(P0.05),对血沉的影响治疗组优于对照组(P0.05);(6)炎症因子:治疗后两组CRP、IL-6及TNF-a均显著降低(P0.05),对CRP、IL-6的影响治疗组优于对照组(P0.05)。结论:精灵方可以有效改善气阴两虚、痰热瘀阻型不稳定型心绞痛患者的临床症状、心电图、血脂、血液流变学、炎症因子等指标,是临床上治疗不稳定型心绞痛的有效方剂,具有良好的药物安全性。
[Abstract]:Objective: to observe the effect of elfin recipe (tonifying qi and nourishing yin, clearing heat, resolving phlegm and activating blood circulation) on symptoms of TCM, effective rate of angina pectoris, electrocardiogram, blood lipid, hemorheology and inflammatory factors in patients with unstable angina pectoris. To evaluate the clinical efficacy of "tonifying qi and nourishing yin, clearing heat, resolving phlegm and activating blood circulation" in the treatment of unstable angina pectoris. Methods: 40 patients with unstable angina pectoris with qi-yin deficiency and phlegm-heat stasis obstruction were randomly divided into two groups: treatment group (n = 20) and control group (n = 20). The patients were divided into two groups: treatment group (n = 20) and control group (n = 20). The control group received standardized treatment of western medicine, the treatment group combined with Jingling recipe on the basis of the control group, both groups were treated for 8 weeks. The changes of TCM symptom integral effect, angina pectoris effective rate, electrocardiogram, blood lipid, hemorheology and inflammatory factors were compared between the two groups before and after treatment, and the clinical curative effect was analyzed. Results: (1) TCM symptom score and curative effect: after treatment, the TCM symptom score of the two groups were significantly improved (P0.05), the total effective rate of the treatment group was 90%, the total effective rate of the control group was 60%, the improvement of the treatment group was better than that of the control group (P0.05); (2) the effective rate of angina pectoris: after treatment, the symptoms of angina pectoris in the two groups were significantly improved (P0.05), the total effective rate of the treatment group was 90%, the total effective rate of the control group was 85%, there was no difference between the treatment group and the control group (P0.05); (3) ECG: after treatment, the ECG of the two groups were significantly improved (P0.05), the total effective rate of the treatment group was 75%, the total effective rate of the control group was 55%, and there was no difference between the treatment group and the control group (P0.05); (4) Blood lipid: after treatment, the TC,TG,LDL-c of the two groups decreased significantly (P0.05), the treatment group was superior to the control group (P0.05), and the HDL-c of the two groups did not increase significantly after treatment (P0.05). (5) Hemorheology: after treatment, the blood viscosity and erythrocyte sedimentation rate (ESR) of the two groups decreased significantly (P0.05), and the effect of the treatment group on ESR was better than that of the control group (P0.05). (6) inflammatory factors: after treatment, both CRP,IL-6 and TNF-a were significantly decreased in the two groups (P0.05), and the effect on CRP,IL-6 in the treatment group was better than that in the control group (P0.05). Conclusion: Jingling recipe can effectively improve the clinical symptoms, electrocardiogram, blood lipid, hemorheology and inflammatory factors in patients with unstable angina pectoris due to deficiency of both qi and yin and phlegm-heat stasis. It is an effective prescription for treating unstable angina pectoris. It has good drug safety.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259
本文编号：2453880
[Abstract]:Objective: to observe the effect of elfin recipe (tonifying qi and nourishing yin, clearing heat, resolving phlegm and activating blood circulation) on symptoms of TCM, effective rate of angina pectoris, electrocardiogram, blood lipid, hemorheology and inflammatory factors in patients with unstable angina pectoris. To evaluate the clinical efficacy of "tonifying qi and nourishing yin, clearing heat, resolving phlegm and activating blood circulation" in the treatment of unstable angina pectoris. Methods: 40 patients with unstable angina pectoris with qi-yin deficiency and phlegm-heat stasis obstruction were randomly divided into two groups: treatment group (n = 20) and control group (n = 20). The patients were divided into two groups: treatment group (n = 20) and control group (n = 20). The control group received standardized treatment of western medicine, the treatment group combined with Jingling recipe on the basis of the control group, both groups were treated for 8 weeks. The changes of TCM symptom integral effect, angina pectoris effective rate, electrocardiogram, blood lipid, hemorheology and inflammatory factors were compared between the two groups before and after treatment, and the clinical curative effect was analyzed. Results: (1) TCM symptom score and curative effect: after treatment, the TCM symptom score of the two groups were significantly improved (P0.05), the total effective rate of the treatment group was 90%, the total effective rate of the control group was 60%, the improvement of the treatment group was better than that of the control group (P0.05); (2) the effective rate of angina pectoris: after treatment, the symptoms of angina pectoris in the two groups were significantly improved (P0.05), the total effective rate of the treatment group was 90%, the total effective rate of the control group was 85%, there was no difference between the treatment group and the control group (P0.05); (3) ECG: after treatment, the ECG of the two groups were significantly improved (P0.05), the total effective rate of the treatment group was 75%, the total effective rate of the control group was 55%, and there was no difference between the treatment group and the control group (P0.05); (4) Blood lipid: after treatment, the TC,TG,LDL-c of the two groups decreased significantly (P0.05), the treatment group was superior to the control group (P0.05), and the HDL-c of the two groups did not increase significantly after treatment (P0.05). (5) Hemorheology: after treatment, the blood viscosity and erythrocyte sedimentation rate (ESR) of the two groups decreased significantly (P0.05), and the effect of the treatment group on ESR was better than that of the control group (P0.05). (6) inflammatory factors: after treatment, both CRP,IL-6 and TNF-a were significantly decreased in the two groups (P0.05), and the effect on CRP,IL-6 in the treatment group was better than that in the control group (P0.05). Conclusion: Jingling recipe can effectively improve the clinical symptoms, electrocardiogram, blood lipid, hemorheology and inflammatory factors in patients with unstable angina pectoris due to deficiency of both qi and yin and phlegm-heat stasis. It is an effective prescription for treating unstable angina pectoris. It has good drug safety.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259
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