健脾祛湿退黄方治疗新生儿病理性黄疸（阳黄）的临床疗效观察
发布时间：2019-04-17 15:11
【摘要】：目的:观察健脾祛湿退黄方治疗新生儿病理性黄疸(阳黄)的临床疗效及不良反应,为本病提供一个安全有效的治疗方法。方法:将符合诊断标准的患儿分为治疗组和对照组,治疗组32例,对照组30例。治疗组采用健脾祛湿退黄方(党参、白术、黄芪、炒麦芽、六神曲、茵陈、栀子、茯苓、柴胡、金银花)+基础治疗(蓝光治疗+有感染者加用抗生素治疗),对照组使用茵栀黄口服液+基础治疗(蓝光治疗+有感染者加用抗生素治疗),7天为一疗程。观察治疗前后两组患儿中医主证、次证积分变化,一个疗程后血清总胆红素变化、间接胆红素变化,住院天数,血清总胆红素、间接胆红素下降幅度,对两组疗效进行统计学分析。结果:1.对照组治愈9例,显效8例,好转7例,无效6例。治疗组治愈18例,显效8例,好转4例,无效2例。两组疗效的比较差异有统计学意义(P0.05),治疗组优于对照组。2.治疗后治疗组总胆红素下降幅度179±2.31umol/L,间接胆红素下降幅度173.74±0.58umol/L,对照组总胆红素下降幅度159.05±8.79umol/L,间接胆红素下降幅度154.97±1.42umol/L,治疗后对照组与治疗组相比,经t检验,P0.05,差异有统计学意义,治疗后两组血中总胆红素、间接胆红素水平均较前下降,治疗组下降的幅度更大;治疗后对照组与治疗组中医证候积分相比,经t检验,P0.05,差异有统计学意义,治疗后两组中医证候积分均较治疗前下降,治疗组证候积分下降的较显著。3.治疗组住院天数6.29±0.42天,对照组住院天数7.89±0.32天,治疗组住院时间短于对照组,两组比较差异有统计学意义(P0.05)。结论:采用健脾祛湿退黄方治疗新生儿病理性黄疸,疗效明显,对于降低血清总胆红素值、间接胆红素值、改善中医证候、降低不良反应及治愈好转率明显优于茵栀黄口服液对照组,值得临床进一步推广。
[Abstract]:Objective: to observe the clinical efficacy and adverse reactions of Jianpi Qushi Huihuanfang in the treatment of neonatal pathological jaundice (Yang Huang), so as to provide a safe and effective treatment method for this disease. Methods: 32 cases in treatment group and 30 cases in control group were divided into two groups: treatment group (n = 32) and control group (n = 30). The treatment group was treated with basic treatment (Codonopsis pilosula, Atractylodes, Astragalus membranaceus, stir-fried malt, six-Shenqu, Yinchen, Gardenia, Poria cocos, Bupleurum chinense, Flos Lonicerae) basic treatment (blue light treatment with infected persons plus antibiotic treatment), The control group was treated with basic treatment of Yinzhihuang oral liquid (blue light treatment with infection plus antibiotics), 7 days as a course of treatment. After treatment, the changes of serum total bilirubin, indirect bilirubin, hospitalization days, serum total bilirubin and indirect bilirubin were observed before and after treatment, and the decrease of serum total bilirubin, serum total bilirubin and indirect bilirubin were observed before and after treatment. The curative effect of the two groups was analyzed statistically. Results: 1. In the control group, 9 cases were cured, 8 cases were markedly effective, 7 cases were improved and 6 cases were ineffective. In the treatment group, 18 cases were cured, 8 cases were markedly effective, 4 cases were improved and 2 cases were ineffective. There was a significant difference in curative effect between the two groups (P0.05). The treatment group was better than the control group. After treatment, the total bilirubin decreased 179 卤2.31umol / L, indirect bilirubin 173.74 卤0.58umol / L in the treatment group, 159.05 卤8.79umol / L in the control group, 154.97 卤1.42umoll / L in the indirect bilirubin group. After treatment, the control group compared with the treatment group, the t-test, P 0.05, the difference was statistically significant. After treatment, the total bilirubin and indirect bilirubin levels in the two groups were lower than before, and the decrease in the treatment group was greater than that in the control group. After treatment, the scores of TCM syndromes in the control group and the treatment group were significantly lower than those in the treatment group (t test, P 0.05, P 0.05). After treatment, the scores of TCM syndromes in the two groups were all lower than those before treatment. 3. The scores of TCM syndromes in the treatment group were significantly lower than those in the treatment group. The length of hospitalization was 6.29 卤0.42 days in the treatment group and 7.89 卤0.32 days in the control group. The length of hospitalization in the treatment group was shorter than that in the control group, and there was a significant difference between the two groups (P0.05). Conclusion: the method of invigorating the spleen and removing dampness and removing yellow water is effective in the treatment of neonatal pathological jaundice, which is effective in reducing the total serum cholinoid value, indirect cholinergic value and improving the syndrome of traditional Chinese medicine (TCM). The rate of reducing adverse reaction and improving cure was obviously better than that of Yinzhihuang oral liquid group, which was worthy of further popularization in clinical practice.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R272
本文编号：2459548
[Abstract]:Objective: to observe the clinical efficacy and adverse reactions of Jianpi Qushi Huihuanfang in the treatment of neonatal pathological jaundice (Yang Huang), so as to provide a safe and effective treatment method for this disease. Methods: 32 cases in treatment group and 30 cases in control group were divided into two groups: treatment group (n = 32) and control group (n = 30). The treatment group was treated with basic treatment (Codonopsis pilosula, Atractylodes, Astragalus membranaceus, stir-fried malt, six-Shenqu, Yinchen, Gardenia, Poria cocos, Bupleurum chinense, Flos Lonicerae) basic treatment (blue light treatment with infected persons plus antibiotic treatment), The control group was treated with basic treatment of Yinzhihuang oral liquid (blue light treatment with infection plus antibiotics), 7 days as a course of treatment. After treatment, the changes of serum total bilirubin, indirect bilirubin, hospitalization days, serum total bilirubin and indirect bilirubin were observed before and after treatment, and the decrease of serum total bilirubin, serum total bilirubin and indirect bilirubin were observed before and after treatment. The curative effect of the two groups was analyzed statistically. Results: 1. In the control group, 9 cases were cured, 8 cases were markedly effective, 7 cases were improved and 6 cases were ineffective. In the treatment group, 18 cases were cured, 8 cases were markedly effective, 4 cases were improved and 2 cases were ineffective. There was a significant difference in curative effect between the two groups (P0.05). The treatment group was better than the control group. After treatment, the total bilirubin decreased 179 卤2.31umol / L, indirect bilirubin 173.74 卤0.58umol / L in the treatment group, 159.05 卤8.79umol / L in the control group, 154.97 卤1.42umoll / L in the indirect bilirubin group. After treatment, the control group compared with the treatment group, the t-test, P 0.05, the difference was statistically significant. After treatment, the total bilirubin and indirect bilirubin levels in the two groups were lower than before, and the decrease in the treatment group was greater than that in the control group. After treatment, the scores of TCM syndromes in the control group and the treatment group were significantly lower than those in the treatment group (t test, P 0.05, P 0.05). After treatment, the scores of TCM syndromes in the two groups were all lower than those before treatment. 3. The scores of TCM syndromes in the treatment group were significantly lower than those in the treatment group. The length of hospitalization was 6.29 卤0.42 days in the treatment group and 7.89 卤0.32 days in the control group. The length of hospitalization in the treatment group was shorter than that in the control group, and there was a significant difference between the two groups (P0.05). Conclusion: the method of invigorating the spleen and removing dampness and removing yellow water is effective in the treatment of neonatal pathological jaundice, which is effective in reducing the total serum cholinoid value, indirect cholinergic value and improving the syndrome of traditional Chinese medicine (TCM). The rate of reducing adverse reaction and improving cure was obviously better than that of Yinzhihuang oral liquid group, which was worthy of further popularization in clinical practice.
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R272
【参考文献】
相关期刊论文 前10条
1 潘佩光;陈建宏;王云嫦;;运用中医启脾退黄法预防新生儿黄疸临床观察[J];新中医;2014年05期
2 刘初凤;;早期护理干预在新生儿黄疸治疗中的应用效果[J];中外医学研究;2013年27期
3 毛文英;;蓝光照射治疗新生儿黄疸疗效观察[J];中国民族民间医药;2013年03期
4 赵冬莹;张拥军;;新生儿高胆红素血症的治疗进展[J];临床儿科杂志;2012年09期
5 何建勋;;新生儿高胆红素血症236例病因及诊治分析[J];中国当代医药;2011年11期
6 陈雁;张现涛;张雷红;杨中林;;栀子化学成分及药理作用研究进展[J];海峡药学;2010年12期
7 林霄;;茵陈蒿的药理作用研究[J];长春中医药大学学报;2008年06期
8 刘媛媛;欧阳龙明;唐亚敏;;中西医结合治疗脾湿型新生儿黄疸的临床观察[J];实用临床医学;2008年09期
9 董岩;王新芳;崔长军;付风刚;;茵陈蒿的化学成分和药理作用研究进展[J];时珍国医国药;2008年04期
10 孟文丽;;新生儿退黄汤预防新生儿病理性黄疸的疗效观察[J];北京中医药;2008年02期
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