基于SPECT技术评价潜阳育阴颗粒改善高血压患者早期肾脏损害作用的研究
发布时间：2019-05-12 15:59
【摘要】：目的:在降压达标基础上(氨氯地平或联合缬沙坦,收缩压(SBP)"f140mmHg和舒张压(DBP)"f90mmHg)基于SPECT技术评价潜阳育阴颗粒改善高血压患者早期肾脏损害作用。方法:入选符合阴虚阳亢证型的高血压早期肾损害的住院或门诊的60例患者,随机分为两组,每组30例,在规范降压方案(氨氯地平5 mg/d,必要时加量至10 mg/d,或必要时加用缬沙坦)控制血压达标基础上(收缩压(SBP)"f140mmmHg和舒张压(DBP)"f90mmmHg),治疗组给予潜阳育阴颗粒20g,2/日,早晚服用;对照组为空白对照不再加用其它保护肾脏功能的中西药物,共干预24周。治疗后观察两组病人的中医证候、实验室指标、血压、心率。实验室指标为:尿β 2微球蛋白(B2-mG),血清光抑素C(Cyst-C),尿N-乙酰-β-D-葡萄糖苷酶(NAG)及SPECT测得的肾小球滤过率(GFR)。治疗结束后将数据输入SPSS程序中进行分析。结果:1.潜阳育阴颗粒对肾脏损害指标的影响:治疗组各组肾损害指标治疗后均明显改善(P0.05);对照组治疗后Cyst-C、B2-mG改善明显,有统计学差异(P0.05);对照组NAG、GFR未见改善,无统计学意义(P0.05);治疗组与对照组治疗后比较,治疗组较对照组改善明显(P0.05)。2.中医证候疗效方面:中医证候总积分治疗组治疗后明显降低(P0.05),具有统计学意义;对照组治疗后明显降低(P0.05),具有统计学意义;治疗组与对照组治疗后比较改善明显(P0.01),有极显著差异。各组症状中医证候积分治疗组治疗后除健忘外其余中医证候积分均明显降低(P0.01),具有极显著差异;对照组除膝软、健忘、舌苔、细脉外治疗后中医证候积分均降低(P0.05),具有统计学差异;治疗组与对照组治疗后比较,除失眠、健忘、细脉外中医证候积分均降低(P0.05),其中眩晕、腰酸、弦脉中医证候积分降低极为显著(P0.01),均具有统计学意义。结论:潜阳育阴颗粒在西药降压达标基础上能改善阴虚阳亢型高血压患者的肾脏损害,同时进一步改善中医相关临床症状,达到高质量的降压。
[Abstract]:Aim: to evaluate the effect of Qianyang Yuyin granule on early renal damage in patients with hypertension based on SPECT (amlodipine or combined with valsartan, systolic blood pressure (SBP) "f140mmHg and diastolic blood pressure (DBP)" f90mmHg). Methods: 60 inpatients with early renal damage of hypertension with syndrome of yin deficiency and yang hyperactivity were randomly divided into two groups with 30 patients in each group. The dosage of amlodipine 5 mg/d, was increased to 10 mg/d, when necessary. Or if necessary, valsartan was used to control blood pressure (systolic blood pressure (SBP) "f140mmmHg and diastolic blood pressure (DBP)" f90mmmHg). The treatment group was given Qianyang Yuyin granule 20 g, 2 / day, in the morning and evening. The control group was treated with other Chinese and Western drugs to protect renal function for 24 weeks. After treatment, the TCM syndrome, laboratory index, blood pressure and heart rate of the two groups were observed. The laboratory indexes were as follows: urine 尾 2 microglobulin (B2-mG), serum photostatin C (Cyst-C), urine N-acetyl尾-D-glucosidase (NAG) and SPECT. The glomerular filtration rate (GFR).) was measured by urine 尾 2 microglobulin (GFR).), serum photostatin C (GFR).), urine N-acetyl尾-D-glucosidase (GFR). After the treatment, the data were input into the SPSS program for analysis. Result: 1. The effect of Qianyang Yuyin granule on renal damage index: the renal damage index of each group in the treatment group was significantly improved after treatment (P 0.05), and the Cyst-C,B2-mG in the control group was significantly improved after treatment (P 0.05). There was no significant improvement in NAG,GFR in the control group (P0.05), and there was no significant difference between the treatment group and the control group (P0.05); the treatment group was significantly improved compared with the control group after treatment (P0.05). TCM syndrome curative effect: TCM syndrome total integral treatment group significantly decreased after treatment (P0.05), with statistical significance; control group after treatment significantly decreased (P0.05), with statistical significance; Compared with the control group, the treatment group improved significantly after treatment (P0.01), there was a significant difference between the treatment group and the control group. After treatment, the scores of TCM syndromes in the treatment group except forgetfulness were significantly decreased (P0.01), and there was a significant difference between the treatment group and the traditional Chinese medicine syndrome integral group (P < 0.01). In the control group, except knee soft, forgetfulness, tongue coating and veinlets, the scores of TCM syndrome were all decreased after treatment (P0.05), with statistical difference. After treatment, the scores of TCM syndromes in the treatment group were significantly lower than those in the control group (P 0.05), except insomnia, amnesia and veinlets (P 0.05), and the scores of vertigo, lumbar acid and string pulse were significantly lower than those in the control group (P 0.01). Conclusion: Qianyang Yuyin granule can improve the renal damage of hypertension patients with yin deficiency and yang hyperactivity on the basis of western medicine, and further improve the related clinical symptoms of traditional Chinese medicine, so as to achieve high quality hypotension.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259
本文编号：2475504
[Abstract]:Aim: to evaluate the effect of Qianyang Yuyin granule on early renal damage in patients with hypertension based on SPECT (amlodipine or combined with valsartan, systolic blood pressure (SBP) "f140mmHg and diastolic blood pressure (DBP)" f90mmHg). Methods: 60 inpatients with early renal damage of hypertension with syndrome of yin deficiency and yang hyperactivity were randomly divided into two groups with 30 patients in each group. The dosage of amlodipine 5 mg/d, was increased to 10 mg/d, when necessary. Or if necessary, valsartan was used to control blood pressure (systolic blood pressure (SBP) "f140mmmHg and diastolic blood pressure (DBP)" f90mmmHg). The treatment group was given Qianyang Yuyin granule 20 g, 2 / day, in the morning and evening. The control group was treated with other Chinese and Western drugs to protect renal function for 24 weeks. After treatment, the TCM syndrome, laboratory index, blood pressure and heart rate of the two groups were observed. The laboratory indexes were as follows: urine 尾 2 microglobulin (B2-mG), serum photostatin C (Cyst-C), urine N-acetyl尾-D-glucosidase (NAG) and SPECT. The glomerular filtration rate (GFR).) was measured by urine 尾 2 microglobulin (GFR).), serum photostatin C (GFR).), urine N-acetyl尾-D-glucosidase (GFR). After the treatment, the data were input into the SPSS program for analysis. Result: 1. The effect of Qianyang Yuyin granule on renal damage index: the renal damage index of each group in the treatment group was significantly improved after treatment (P 0.05), and the Cyst-C,B2-mG in the control group was significantly improved after treatment (P 0.05). There was no significant improvement in NAG,GFR in the control group (P0.05), and there was no significant difference between the treatment group and the control group (P0.05); the treatment group was significantly improved compared with the control group after treatment (P0.05). TCM syndrome curative effect: TCM syndrome total integral treatment group significantly decreased after treatment (P0.05), with statistical significance; control group after treatment significantly decreased (P0.05), with statistical significance; Compared with the control group, the treatment group improved significantly after treatment (P0.01), there was a significant difference between the treatment group and the control group. After treatment, the scores of TCM syndromes in the treatment group except forgetfulness were significantly decreased (P0.01), and there was a significant difference between the treatment group and the traditional Chinese medicine syndrome integral group (P < 0.01). In the control group, except knee soft, forgetfulness, tongue coating and veinlets, the scores of TCM syndrome were all decreased after treatment (P0.05), with statistical difference. After treatment, the scores of TCM syndromes in the treatment group were significantly lower than those in the control group (P 0.05), except insomnia, amnesia and veinlets (P 0.05), and the scores of vertigo, lumbar acid and string pulse were significantly lower than those in the control group (P 0.01). Conclusion: Qianyang Yuyin granule can improve the renal damage of hypertension patients with yin deficiency and yang hyperactivity on the basis of western medicine, and further improve the related clinical symptoms of traditional Chinese medicine, so as to achieve high quality hypotension.
【学位授予单位】：南京中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R259
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