健脾理气法治疗2型糖尿病胃轻瘫的系统评价
发布时间：2019-05-13 13:01
【摘要】：目的:评价健脾理气法治疗2型糖尿病胃轻瘫的疗效和安全性,并探讨其可能作用机制,为健脾理气法治疗2型糖尿病胃轻瘫提供循证依据。方法:1确定检索关键词,通过计算机对PubMed、Embase、The Cochrane Library等国外数据库及万方数据库、中国知网等国内数据库2006年01月至2016年12月期间国内外发表的健脾理气法治疗2型糖尿病胃轻瘫的临床研究文献进行检索。2根据纳入、排除标准,选取符合纳入条件的文献,使用RevMan 5.2软件对健脾理气法治疗2型糖尿病胃轻瘫的总有效率、痊愈率、胃排空率、糖代谢指标、胃动素、不良反应等指标进行Meta分析。结果:本研究共纳入29篇符合纳入条件的随机对照试验,结果显示,健脾理气法治疗2型糖尿病胃轻瘫在总有效率(RR=1.25,95%CI:[1.20,1.30],P0.05)、痊愈率(RR=1.83,95%CI:[1.44,2.33],P0.05)、胃排空率(MD=6.20,95%CI:[4.37,8.04],P0.05)、空腹血糖(MD=-0.69,95%CI:[-0.83,-0.54],P0.05)、餐后2h血糖(MD=-1.00,95%CI:[-1.27,-0.73],P0.05)、糖化血红蛋白(MD=-1.04,95%CI:[-1.28,-0.80],P0.05)、胃动素(放射免疫法RIA:MD=-87.27,95%CI:[-135.92,-38.63],P0.05;酶联免疫吸附法ELISA:MD=-62.94,95%CI:[-99.21,-26.67],P0.05)、不良反应(RR=0.16,95%CI:[0.04,0.60],P0.05)方面优于对照组,疗效显著。结论:1健脾理气法治疗2型糖尿病胃轻瘫有显著疗效,可明显提高胃排空率,疗效优于西药对照组。2健脾理气法可明显改善患者糖代谢紊乱情况,降低患者胃动素,此可能为健脾理气法治疗2型糖尿病胃轻瘫的作用机制之一。3健脾理气法治疗2型糖尿病胃轻瘫有良好的安全性。4限于纳入研究的文献质量不高,部分指标样本量少,尚需进一步大样本、多中心的双盲随机对照试验加以验证。
[Abstract]:Objective: to evaluate the efficacy and safety of invigorating spleen and regulating qi in the treatment of type 2 diabetic gastroparesis, and to explore its possible mechanism, so as to provide evidence basis for the treatment of type 2 diabetic gastroparesis by invigorating spleen and regulating qi. Methods: 1 the key words were determined, and the foreign databases such as PubMed,Embase,The Cochrane Library and Wanfang database were analyzed by computer. From January 2006 to December 2016, the domestic databases such as China knowledge Network published the literature of clinical research on the treatment of gastroparesis with type 2 diabetes mellitus by invigorating the spleen and regulating qi. 2 according to the inclusion and exclusion criteria, the literature eligible for inclusion was selected. The total effective rate, cure rate, gastric emptying rate, glucose metabolism index, motilin and adverse reactions of type 2 diabetic gastroparesis treated by invigorating spleen and regulating qi were analyzed by RevMan 5.2 software. Results: a total of 29 randomized controlled trials were included in this study. The results showed that the total effective rate of invigorating spleen and regulating qi in the treatment of type 2 diabetic gastroparesis (RR=1.25,95%CI: [1.20, 1.30], P05). Cure rate (RR=1.83,95%CI: [1.44, 2.33], P 0.05), gastric emptying rate (MD=6.20,95%CI: [4.37, 8.04], P 0.05), fasting blood glucose (MD=-0.69,95%CI: [- 0.83, 鈮，
本文编号：2475909
[Abstract]:Objective: to evaluate the efficacy and safety of invigorating spleen and regulating qi in the treatment of type 2 diabetic gastroparesis, and to explore its possible mechanism, so as to provide evidence basis for the treatment of type 2 diabetic gastroparesis by invigorating spleen and regulating qi. Methods: 1 the key words were determined, and the foreign databases such as PubMed,Embase,The Cochrane Library and Wanfang database were analyzed by computer. From January 2006 to December 2016, the domestic databases such as China knowledge Network published the literature of clinical research on the treatment of gastroparesis with type 2 diabetes mellitus by invigorating the spleen and regulating qi. 2 according to the inclusion and exclusion criteria, the literature eligible for inclusion was selected. The total effective rate, cure rate, gastric emptying rate, glucose metabolism index, motilin and adverse reactions of type 2 diabetic gastroparesis treated by invigorating spleen and regulating qi were analyzed by RevMan 5.2 software. Results: a total of 29 randomized controlled trials were included in this study. The results showed that the total effective rate of invigorating spleen and regulating qi in the treatment of type 2 diabetic gastroparesis (RR=1.25,95%CI: [1.20, 1.30], P05). Cure rate (RR=1.83,95%CI: [1.44, 2.33], P 0.05), gastric emptying rate (MD=6.20,95%CI: [4.37, 8.04], P 0.05), fasting blood glucose (MD=-0.69,95%CI: [- 0.83, 鈮，
本文编号：2475909
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