50例原发性肾癌患者中医用药规律的临床研究
发布时间：2019-05-13 23:31
【摘要】：目的:分析原发性肾癌患者在不同疾病阶段的治疗情况,观察中医药在参与原发性肾癌患者治疗中的应用情况,研究原发性肾癌的中医用药规律,为临床治疗本病提供有价值的参考。资料与方法:回顾性收集在2013年3月一2016年2月于辽宁中医药大学附属医院肿瘤科住院的以原发性肾癌为第一诊断的患者的资料,选取其中符合条件的病例,用Microsoft Excel软件建立数据库,分别统计患者西医的对症治疗方法、中成药数量的应用情况、具有抗癌作用的中药应用数量情况、中药方剂的具体应用情况,中药药物分类和药味。结果:1.原发性肾癌患者的一般资料:此次统计共有原发性肾癌患者50例,其中男性32例、女性18例;年龄最小33岁,最大91岁,平均年龄(68.21±10.28);早期8例、中期17例、晚期16例、终末期9例;肺转移17例、骨转移12例、肝转移6例、淋巴结转移4例、腹膜转移4例、乳腺转移1例、膀胱转移1例;行手术治疗者24例、行靶向治疗者18例、行生物免疫治疗者23例。2.原发性肾癌患者西医的对症治疗方法:在早期,以提高免疫力治疗和抗炎治疗为主,在中期,以提高免疫力治疗和骨保护治疗为主,在晚期,以提高免疫力治疗和抗炎治疗为主,在前三期提高免疫力均是最主要的治疗;在终末期,以营养治疗和抗炎治疗为主。3.中成药的具体应用情况:在早期应用最多的中成药是:抗癌类中成药;在中期应用最多的中成药是:抗癌类中成药,晚期应用最多的中成药是:扶正类中成药;终末期应用最多的中成药是:扶正类中成药。4.原发性肾癌患者具有作用抗癌的中药应用数量的情况:在早期3~5味抗癌中药应用最多,共有5例,在中期6~8味抗癌中药应用最多,共有9例,在晚期1~2味抗癌中药应用最多,共有9例,在终末期不应用具有抗癌作用的中药。5.在早期:六味地黄汤合柴胡龙骨牡蛎汤加减应用最多;在中期:六味地黄汤合柴胡龙骨牡蛎汤加减应用最多;在晚期:六味地黄汤合四君子汤加减应用最多。6.在治疗原发性肾癌的过程中,中药药物分类中补虚药应用最多,其次是利水渗湿药和清热药,三者的比例超过了50%,药味以甘,苦,辛为主,甘味占绝对优势。结论:1.在原发性肾癌患者治疗的过程中,六味地黄汤应用最多;中药药物分类中补虚药、利水渗湿药和清热药应用最多;药味以甘、苦、辛所占比例最多。2.早期中医治疗以减轻手术反应及对症治疗,以促进术后中气的恢复、预防肿瘤的复发转移为主要的治疗思路。3.中期中医治疗以抗癌为主,扶正为辅为主要的治疗思路。4.晚期中医治疗以扶正为主,抗癌为辅为主要的治疗思路。5.终末期中医治疗以扶正和对症治疗为主要的治疗思路。
[Abstract]:Objective: to analyze the treatment of primary renal cell carcinoma (RCC) in different stages, to observe the application of traditional Chinese medicine (TCM) in the treatment of primary renal cell carcinoma (RCC), and to study the regularity of TCM medication in PRCC. It provides valuable reference for clinical treatment of this disease. Materials and methods: the data of primary renal cell carcinoma hospitalized in the Department of Oncology, affiliated Hospital of Liaoning University of traditional Chinese Medicine from March 2013 to February 2016 were collected retrospectively. the eligible cases were selected. The database was established by Microsoft Excel software to count the symptomatic treatment of patients with western medicine, the application of proprietary Chinese medicine, the quantity of traditional Chinese medicine with anticancer effect, the specific application of traditional Chinese medicine prescription, the classification and taste of traditional Chinese medicine. Result: 1. General data of patients with primary renal carcinoma: there were 50 patients with primary renal cancer, including 32 males and 18 females, the youngest was 33 years old, the oldest was 91 years old, and the average age was 68.21 卤10.28). There were 8 cases of early, 17 cases of middle stage, 16 cases of late stage, 9 cases of end stage, 17 cases of lung metastasis, 12 cases of bone metastasis, 6 cases of liver metastasis, 4 cases of lymph node metastasis, 4 cases of peritoneal metastasis, 1 case of breast metastasis and 1 case of bladder metastasis. 24 cases were treated surgically, 18 cases were treated with targeted therapy, and 23 cases were treated with bioimmunotherapy. Symptomatic treatment of patients with primary renal cancer: in the early stage, mainly to improve immunity therapy and anti-inflammatory treatment, in the middle stage, to improve immunity therapy and bone protection treatment, in the late stage, In order to improve immunity therapy and anti-inflammatory treatment, improving immunity in the first three stages is the most important treatment. At the end-stage, nutritional therapy and anti-inflammatory therapy were the main treatments. The specific application of proprietary Chinese medicine: the most widely used proprietary Chinese medicine in the early stage is: anticancer proprietary Chinese medicine, the most widely used Chinese patent medicine in the middle stage is: anticancer proprietary Chinese medicine, the most widely used traditional Chinese patent medicine in the late stage is: Fuzheng proprietary Chinese patent medicine; The most commonly used proprietary Chinese medicine in the end-stage is Fuzheng proprietary Chinese medicine. 4. The number of traditional Chinese medicine with anticancer effect in patients with primary renal cancer: in the early stage, 5 cases were used, 6 cases were used in the middle stage, 9 cases were used in the middle stage, and the most were used in the late stage of 1 and 2 kinds of anticancer traditional Chinese medicine, which were the most widely used in the early stage of 3 kinds of anticancer traditional Chinese medicine, 5 cases in the middle stage, 9 cases in the middle stage. A total of 9 cases, in the end-stage of the use of traditional Chinese medicine with anticancer effect. 5. In the early stage: Liuwei Dihuang decoction Hechaihu Dragon Bone Oyster soup was the most widely used; in the middle stage: Liuwei Dihuang decoction and Bupleurum keel Oyster soup was the most widely used; in the late stage: Liuwei Dihuang decoction and Sijunzi decoction were the most widely used. 6. In the process of treating primary renal cell carcinoma, tonifying deficiency drugs were the most widely used in the classification of traditional Chinese medicine, followed by dampness drugs and antipyretic drugs, the proportion of which was more than 50%. The taste of drugs was mainly sweet, bitter and Xin, and sweet flavor was the absolute advantage. Conclusion: 1. Liuwei Dihuang decoction is the most widely used in the treatment of patients with primary renal cell carcinoma. In the classification of traditional Chinese medicine, tonifying deficiency drugs, promoting dampness drugs and clearing away heat drugs are the most used, and the proportion of sweet, bitter and Xin is the most. 2. (2) in the process of treatment of patients with primary renal cancer, Liuwei Dihuang decoction is the most widely used in the classification of traditional Chinese medicine. The main treatment idea of early traditional Chinese medicine treatment is to reduce the surgical reaction and symptomatic treatment, to promote the recovery of qi after operation, and to prevent the recurrence and metastasis of tumor. 3. The main treatment idea of middle stage traditional Chinese medicine is anticancer, Fuzheng as auxiliary. 4. The treatment of advanced traditional Chinese medicine is mainly Fuzheng, supplemented by anticancer. 5. The main treatment idea of end-stage traditional Chinese medicine is Fuzheng and symptomatic treatment.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R273
本文编号：2476263
[Abstract]:Objective: to analyze the treatment of primary renal cell carcinoma (RCC) in different stages, to observe the application of traditional Chinese medicine (TCM) in the treatment of primary renal cell carcinoma (RCC), and to study the regularity of TCM medication in PRCC. It provides valuable reference for clinical treatment of this disease. Materials and methods: the data of primary renal cell carcinoma hospitalized in the Department of Oncology, affiliated Hospital of Liaoning University of traditional Chinese Medicine from March 2013 to February 2016 were collected retrospectively. the eligible cases were selected. The database was established by Microsoft Excel software to count the symptomatic treatment of patients with western medicine, the application of proprietary Chinese medicine, the quantity of traditional Chinese medicine with anticancer effect, the specific application of traditional Chinese medicine prescription, the classification and taste of traditional Chinese medicine. Result: 1. General data of patients with primary renal carcinoma: there were 50 patients with primary renal cancer, including 32 males and 18 females, the youngest was 33 years old, the oldest was 91 years old, and the average age was 68.21 卤10.28). There were 8 cases of early, 17 cases of middle stage, 16 cases of late stage, 9 cases of end stage, 17 cases of lung metastasis, 12 cases of bone metastasis, 6 cases of liver metastasis, 4 cases of lymph node metastasis, 4 cases of peritoneal metastasis, 1 case of breast metastasis and 1 case of bladder metastasis. 24 cases were treated surgically, 18 cases were treated with targeted therapy, and 23 cases were treated with bioimmunotherapy. Symptomatic treatment of patients with primary renal cancer: in the early stage, mainly to improve immunity therapy and anti-inflammatory treatment, in the middle stage, to improve immunity therapy and bone protection treatment, in the late stage, In order to improve immunity therapy and anti-inflammatory treatment, improving immunity in the first three stages is the most important treatment. At the end-stage, nutritional therapy and anti-inflammatory therapy were the main treatments. The specific application of proprietary Chinese medicine: the most widely used proprietary Chinese medicine in the early stage is: anticancer proprietary Chinese medicine, the most widely used Chinese patent medicine in the middle stage is: anticancer proprietary Chinese medicine, the most widely used traditional Chinese patent medicine in the late stage is: Fuzheng proprietary Chinese patent medicine; The most commonly used proprietary Chinese medicine in the end-stage is Fuzheng proprietary Chinese medicine. 4. The number of traditional Chinese medicine with anticancer effect in patients with primary renal cancer: in the early stage, 5 cases were used, 6 cases were used in the middle stage, 9 cases were used in the middle stage, and the most were used in the late stage of 1 and 2 kinds of anticancer traditional Chinese medicine, which were the most widely used in the early stage of 3 kinds of anticancer traditional Chinese medicine, 5 cases in the middle stage, 9 cases in the middle stage. A total of 9 cases, in the end-stage of the use of traditional Chinese medicine with anticancer effect. 5. In the early stage: Liuwei Dihuang decoction Hechaihu Dragon Bone Oyster soup was the most widely used; in the middle stage: Liuwei Dihuang decoction and Bupleurum keel Oyster soup was the most widely used; in the late stage: Liuwei Dihuang decoction and Sijunzi decoction were the most widely used. 6. In the process of treating primary renal cell carcinoma, tonifying deficiency drugs were the most widely used in the classification of traditional Chinese medicine, followed by dampness drugs and antipyretic drugs, the proportion of which was more than 50%. The taste of drugs was mainly sweet, bitter and Xin, and sweet flavor was the absolute advantage. Conclusion: 1. Liuwei Dihuang decoction is the most widely used in the treatment of patients with primary renal cell carcinoma. In the classification of traditional Chinese medicine, tonifying deficiency drugs, promoting dampness drugs and clearing away heat drugs are the most used, and the proportion of sweet, bitter and Xin is the most. 2. (2) in the process of treatment of patients with primary renal cancer, Liuwei Dihuang decoction is the most widely used in the classification of traditional Chinese medicine. The main treatment idea of early traditional Chinese medicine treatment is to reduce the surgical reaction and symptomatic treatment, to promote the recovery of qi after operation, and to prevent the recurrence and metastasis of tumor. 3. The main treatment idea of middle stage traditional Chinese medicine is anticancer, Fuzheng as auxiliary. 4. The treatment of advanced traditional Chinese medicine is mainly Fuzheng, supplemented by anticancer. 5. The main treatment idea of end-stage traditional Chinese medicine is Fuzheng and symptomatic treatment.
【学位授予单位】：辽宁中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R273
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