益肾方治疗肾虚型乳腺癌骨转移的临床疗效观察

发布时间：2019-05-16 00:49

【摘要】：目的:观察益肾方与唑来膦酸注射液联合使用治疗肾虚型乳腺癌骨转移患者的临床疗效。方法:收集符合诊断标准的肾虚型乳腺癌骨转移患者60例。采用随机数字表分配的原则分为两组,即治疗组30例和对照组30例。治疗组服用自拟益肾方,以中药颗粒剂(999牌,购自河南中医药大学第三附属院),并按规定用量服用,每日1剂,早晚各一次冲服;并输注唑来膦酸注射液4mg(天晴依泰),配入0.9%氯化钠注射液100m L中,持续静脉滴注15~30min,每4周1次,4周后观察临床疗效。对照组则单独应用唑来膦酸注射液(方法、剂量、频次同上)。治疗时间每4周为1周期,共3周期。治疗结束后分别观察治疗组和对照组用药前后疼痛缓解程度、生活质量指数的变化、中医证候积分及患者治疗前后ECT、CT、X线等影像学检查的对比,并对结果进行统计学分析。结果:治疗前两组患者在年龄、疼痛程度、KPS评分、中医证候积分、影像学检查等方面,经统计学分析无显著性差异,对比具有可行性。治疗结束后,两组患者均有不同程度的好转,治疗组在总体疗效上优于对照组,且毒副作用轻微。结论:1.自拟益肾方联合唑来膦酸注射液治疗肾虚型乳腺癌骨转移可显著提高唑来膦酸注射液临床疗效,改善患者肾虚状态;2.本研究表明补肾类中药既抑制破骨细胞对骨的溶解作用,又增强成骨细胞的活性,明显缓解骨转移疼痛,提高了患者的生活质量;并能促进溶骨性病灶的恢复,减慢了疾病的进展。
[Abstract]:Objective: to observe the clinical effect of Yishen recipe combined with zoledronic acid injection in the treatment of bone metastasis of breast cancer with kidney deficiency. Methods: 60 patients with bone metastasis of kidney deficiency breast cancer were collected. According to the principle of random digital table distribution, the treatment group (n = 30) and the control group (n = 30) were divided into two groups. The treatment group took self-made Yishen recipe, with traditional Chinese medicine granules (999 brand, purchased from the third affiliated Hospital of Henan University of traditional Chinese Medicine), and according to the prescribed dosage, 1 dose a day, each time in the morning and evening. Zoledronic acid injection 4mg (Tianqing Yitai) was infused with 0.9% sodium chloride injection 100m L, continuous intravenous drip for 15 min, once every 4 weeks, and the clinical effect was observed after 4 weeks. The control group was treated with zoledronic acid injection (method, dose, frequency as above). The treatment time was 1 cycle every 4 weeks for a total of 3 cycles. After treatment, the changes of pain relief degree, quality of life index, TCM syndrome score and ECT,CT, X-ray examination before and after treatment were observed between the treatment group and the control group. The results were statistically analyzed. Results: there was no significant difference in age, pain degree, KPS score, TCM syndrome score and imaging examination between the two groups before treatment. After treatment, the patients in both groups were improved in varying degrees, and the overall curative effect of the treatment group was better than that of the control group, and the toxic and side effects were mild. Conclusion: 1. Self-made Yishen recipe combined with zoledronic acid injection in the treatment of bone metastasis of breast cancer with kidney deficiency can significantly improve the clinical efficacy of zoledronic acid injection and improve the condition of kidney deficiency. 2. This study showed that traditional Chinese medicine for tonifying the kidney not only inhibited the osteolysis of osteoclasts, but also enhanced the activity of osteoblasts, obviously alleviated bone metastasis pain and improved the quality of life of patients. It can also promote the recovery of osteolytic lesions and slow down the progress of the disease.
【学位授予单位】：河南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R273

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