益气活血汤内服联合电针对SCI患者神经功能康复的疗效分析

发布时间：2019-05-18 18:43

【摘要】：目的观察益气活血汤内服联合电针对脊髓损伤(SCI)患者神经功能康复的效果及对血清脑源性神经生长因子(BDNF)、胰岛素样生长因子1(IGF-1)和神经生长因子(NGF)水平的影响。方法将120例SCI患者分为观察组和对照组,各60例。对照组采用单唾液酸四己糖神经节苷脂钠加康复和电针治疗;观察组在对照组的基础给予益气活血汤内服,疗程均为12周。比较两组患者治疗前后美国SCI协会评分(ASIA)、日常生活能力(MBI)、功能综合评定量表(FCA)和气虚脉络瘀阻证评分,以及BDNF、IGF-1和NGF水平。结果治疗后观察组ASIA运动、痛觉和触觉评分,MBI评分和运动功能评分均高于对照组(P0.01);气虚脉络瘀阻证评分低于对照组(P0.01);两组治疗后FCA的认知功能评分比较,差异无统计学意义(P0.05);治疗后观察组MBI、FCA评分分级优于对照组(P0.05),BDNF、IGF-1和NGF水平高于对照组(P0.01)。结论益气活血汤内服联合电针可促进SCI患者BDNF、IGF-1和NGF等神经营养因子的表达,能改善症状,促进神经功能恢复。
[Abstract]:Objective to observe the effect of Yiqi Huoxue decoction combined with acupuncture on the rehabilitation of nerve function in patients with spinal cord injury (SCI) and the effect of serum brain-derived nerve growth factor (BDNF),). Effects of insulin-like growth factor 1 (IGF-1) and nerve growth factor (NGF). Methods 120 patients with SCI were divided into observation group (n = 60) and control group (n = 60). The control group was treated with monosialic acid tetrahexose ganglioside sodium plus rehabilitation and electro-acupuncture, while the observation group was treated with Yiqi Huoxue decoction for 12 weeks. Before and after treatment, the American SCI Association score (ASIA), (MBI), function comprehensive rating scale (FCA), qi deficiency choroid stasis syndrome score, as well as BDNF,IGF-1 and NGF levels were compared between the two groups before and after treatment. Results after treatment, the scores of ASIA exercise, pain and tactile perception, MBI and motor function in the observation group were higher than those in the control group (P 0.01), and the scores of Qi deficiency and choroid stasis syndrome were lower than those in the control group (P 0.01). There was no significant difference in cognitive function score of FCA between the two groups after treatment (P 0.05). After treatment, the score of MBI,FCA in the observation group was better than that in the control group (P 0.05), and the levels of BDNF,IGF-1 and NGF in the observation group were higher than those in the control group (P 0.01). Conclusion Yiqi Huoxue decoction combined with electro-acupuncture can promote the expression of BDNF,IGF-1 and NGF in patients with SCI, improve the symptoms and promote the recovery of nerve function.
【作者单位】：南阳医学高等专科学校针灸骨伤系;河南省中医院骨伤科;河南省中医院脊柱科;
【基金】：河南省教育科学规划课题(2013-JKGHB-0098)
【分类号】：R269

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