叶氏糖肾方治疗临床期糖尿病肾病的临床研究

发布时间：2019-05-18 20:03

【摘要】：目的观察叶氏糖肾方加脐疗治疗脾肾气虚、湿浊瘀阻型临床期糖尿病肾病患者的临床效果。方法 150例患者被随机分为西药组、中西药组和综合组,分别使用西药、中西药和中西药加脐疗,进行为期6个月的临床治疗观察,每组50例。结果中西药组和综合组临床有效率明显高于西药组(分别为84%、88%和60%),24h尿蛋白定量和血肌酐水平明显低于西药组,e GFR明显高于西药组,综合组中医证候总积分明显低于西药组和中西药组,均有统计学意义,P0.05。三组研究过程中未发现严重不良反应。结论叶氏糖肾方对脾肾气虚、湿浊瘀阻型临床期糖尿病肾病患者可缓解临床症状,减少24h尿蛋白,延缓肾功能衰竭,尤其是脐疗能明显减少中医证候积分,经济有效、简便易行,值得临床推广应用。
[Abstract]:Objective to observe the clinical effect of Ye's Tangshen recipe combined with umbilical therapy in the treatment of clinical diabetic nephropathy with deficiency of spleen and kidney qi and dampness and turbid blood stasis. Methods 150 patients were randomly divided into western medicine group, Chinese and western medicine group and comprehensive group. 50 patients in each group were treated with western medicine, Chinese and western medicine plus umbilical therapy for 6 months. Results the clinical effective rate of the Chinese and western medicine group and the comprehensive group was significantly higher than that of the western medicine group (84%, 88% and 60%, respectively). The 24 h urinary protein quantity and serum creatinine level in the western medicine group were significantly lower than those in the western medicine group, which were significantly higher than those in the western medicine group. The total score of TCM syndromes in the comprehensive group was significantly lower than that in the western medicine group and the Chinese and western medicine group, and there was significant difference between the two groups (P 0.05). No serious adverse reactions were found in the three groups. Conclusion Ye's Tangshen recipe can relieve the clinical symptoms, reduce 24 h urinary protein and delay renal failure, especially umbilical therapy can obviously reduce the syndrome score of traditional Chinese medicine (TCM), which can relieve the clinical symptoms, reduce 24 h urine protein and delay renal failure in clinical diabetic nephropathy patients with deficiency of spleen and kidney qi deficiency and dampness turbid blood stasis. It is simple and easy to use, and it is worth popularizing and applying in clinic.
【作者单位】：上海市第七人民医院/上海中医药大学附属第七人民医院;上海市闸北区中心医院;上海市解放军455医院;
【基金】：上海市卫计委科研基金(No.2014LP032A) 上海市科委科研基金(No.15401930600)
【分类号】：R259

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