养血润肤散药浴治疗手足慢性湿疹（血虚风燥证）的临床研究

发布时间：2019-05-22 08:25

【摘要】：目的针对手足慢性湿疹(血虚风燥证)采取中医药联合疗法,采用随机对照临床研究进行本次研究。治疗组选用养血润肤散药浴疗法、当归饮子内服、珂尔维特润修复乳外擦联合治疗,对照组选用温热水浸泡疗法、当归饮子内服、珂尔维特润修复乳外擦联合治疗,正确进行两组治疗前后的疗效积分及综合疗效评定,客观评价养血润肤散药浴疗法的安全性及疗效,为临床甄选更好的疗效外用方剂提供依据。方法本课题采用符合纳入标准的手足慢性湿疹(血虚风燥证)患者入组,用数字随机法分为治疗组和对照组。除基础治疗口服当归饮子加减(免煎颗粒)、外擦珂尔维特润修复乳外,治疗组采用养血润肤散药浴疗法,对照组采用温热水浸泡疗法；隔日1次、每次30分钟,共4周。于治疗前、治疗后分别记录疗效积分及不良反应,借助统计学软件SPSS17.0进行疗效评定。结果①两组治疗前后分别对疗效指标的积分进行组内比较,各项指标积分比较P均0.05,差异有统计学意义,说明两组疗法在红斑、水肿/浸润/丘疹、表皮剥脱/糜烂、苔藓样变、瘙痒程度、干燥疗效方面均有明显改善。②两组治疗后综合疗效组间比较, P0.05,差异无统计学意义,说明两组在综合疗效方面无差异；③两组程度、干燥改善情况优于对照组,对其余指标的疗效方面无优势。④治疗组和对照组两组患者无明显不良反应,说明养血润肤散药浴疗法安全可靠。结论①养血润肤散药浴疗法或温热水浸泡疗法,联合当归饮子内服及珂尔维特润修复乳外擦,均能明显改善手足慢性湿疹(血虚风燥证)患者的临床症状；②养血润肤散药浴疗法在综合疗效方面与温热水浸泡疗法无差异,在缓解瘙痒程度、干燥症状方面优于温热水浸泡疗法；③养血润肤散是治疗手足慢性湿疹(血虚风燥证)有效的外用中药,无明显不良反应,外用安全性高,值得临床推广应用。
[Abstract]:Objective to adopt the combined therapy of traditional Chinese medicine (TCM) for chronic eczema of hand and foot (blood deficiency and wind dryness syndrome). The treatment group was treated with Yangxue moisturizing powder medicine bath therapy, Angelica sinensis decoction internal treatment, Colvitron repair milk external rubbing combined treatment, control group was treated with warm hot water immersion therapy, Angelica sinensis decoction was taken internally, and Colvitron was used to repair milk external rubbing combined treatment. The curative effect score and comprehensive curative effect evaluation of the two groups before and after treatment were carried out correctly, and the safety and curative effect of Yangxue Runfu Powder drug bath therapy were evaluated objectively, so as to provide the basis for the clinical selection of better curative effect external prescription. Methods the patients with chronic eczema of hand and foot (blood deficiency and wind dryness syndrome) were randomly divided into treatment group and control group by digital random method. In addition to the basic treatment of oral Angelica decoction (no decoction particles), the treatment group was treated with Yangxue moisturizing powder bath therapy, the control group was treated with warm hot water immersion therapy, once every other day for 30 minutes for 4 weeks. Before and after treatment, the curative effect score and adverse reactions were recorded, and the curative effect was evaluated by statistical software SPSS17.0. Results 1 the scores of curative effect indexes were compared between the two groups before and after treatment, and the scores of each index were 0.05, the difference was statistically significant, indicating that the two groups had erythema, edema / infiltration / papules, epidermis exfoliation / erosion. There was no significant difference in the comprehensive curative effect between the two groups after treatment, which showed that there was no significant difference in the comprehensive curative effect between the two groups after treatment, which indicated that there was no significant difference in the comprehensive curative effect between the two groups. (3) the improvement of dryness in the two groups was better than that in the control group, and there was no advantage in the curative effect of other indexes. 4 there were no obvious adverse reactions in the treatment group and the control group, which indicated that the drug bath therapy of Yangxue moisturizing Powder was safe and reliable. Conclusion (1) the clinical symptoms of patients with chronic eczema of hands and feet (blood deficiency wind dryness syndrome) can be obviously improved by Yangxue moisturizing powder bath therapy or warm and hot water immersion therapy, combined with internal administration of Angelica sinensis and Corvette run to repair the external wiping of milk, which can obviously improve the clinical symptoms of patients with chronic eczema of hands and feet (blood deficiency wind dryness syndrome). (2) the comprehensive curative effect of Yangxue moisturizing Powder was no different from that of warm hot water immersion therapy, but it was superior to warm hot water immersion therapy in relieving the degree of pruritus and drying symptoms. Yangxue Runfu Powder is an effective external traditional Chinese medicine for the treatment of chronic eczema of hands and feet (blood deficiency wind dryness syndrome). There is no obvious adverse reaction and the safety of external use is high, so it is worth popularizing and applying in clinic.
【学位授予单位】：成都中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R275.9

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