中药胰剂外敷配合2%氢醌减轻烧伤后色素沉着的临床研究

发布时间：2019-06-06 03:52

【摘要】：目的采用前瞻性随机对照试验的方法,探讨中药膜剂外敷联合2%氢醌对于减轻烧伤后色素沉着的有效性和安全性,为烧伤后治疗色素沉着提供临床参考。方法选择在我院接受治疗的烧伤后色素沉着患者60例作为研究对象,采用随机分组方法将其分为A组和B组,每组30例。A组接受中药膜剂外敷治疗,每周2次,8次为一疗程,进行两个疗程治疗,B组患者接受常规治疗,使用千百乳膏外用,1天2次,自行应用。治疗前,采集患者面部局部色素斑图像,用特定的图像分析系统逐个分析图像采集系统采集的色素斑图像,获取色素值；治疗后第1、4、8周复诊,获取色素值；肉眼判断观察组和对照组治疗前后患处的照片,观察疗效,同时比较每位患者治疗前后图像分析系统分析的色素斑色素值改变的百分比,以比较两组患者治疗总有效率。结果1两组患者的年龄、性别、患病过程以及治疗前色素值等指标比较无显著性差异(P0.05),具有可比性。2两组患者治疗后色素值显著低于治疗前(P0.05),提示烧伤后遗留的素色沉着可以自行消退。3治疗后第1、4、8周A组患者色素沉着积分均显著低于B组患者(P0.05),A组患者治疗前后色素斑色素值改变的百分比显著高于B组患者(P0.05)。同时A组患者色素消退时间显著短于B组患者(P0.05),提示接受中药膜剂外敷治疗的效果更加明显,能够明显缩短色素的遗留时间。4治疗结束后,A组患者痊愈0例,显效6例,有效20例,无效4例,治疗总有效率为86.7%；B组痊愈0例,显效2例,有效7例,无效21例,治疗总有效率为30.0%,两组比较差异显著(P0.05)结论轻度烧伤后遗留的色素本身可以自然消退,但使用中药膜剂外敷联合2%氢琨治疗能够显著缩短患者色素消退的时间,提高治疗总有效率,治疗效果明显,同时不良反应少,患者治疗依从性高,值得临床推广应用。
[Abstract]:Objective to investigate the efficacy and safety of external application of traditional Chinese medicine membrane combined with 2% hydroquinone in reducing pigmentation after burn by prospective randomized controlled trial, and to provide clinical reference for the treatment of pigmentation after burn. Methods Sixty patients with postburn pigmentation in our hospital were randomly divided into group A (n = 30) and group B (n = 30). Group A was treated with external application of traditional Chinese medicine membrane twice a week. 8 times as a course of treatment, two courses of treatment, group B patients received routine treatment, using thousands of cream for external use, twice a day, self-application. Before treatment, the local pigmentation images of the patients were collected, and the pigmented images collected by the image acquisition system were analyzed one by one with a specific image analysis system to obtain the pigmented values, and the pigmented values were obtained at the 1st and 4th weeks after treatment. The images of the patients in the observation group and the control group before and after treatment were judged by the naked eye, and the curative effect was observed. at the same time, the percentage of pigmented changes analyzed by the image analysis system before and after treatment was compared to compare the total effective rate between the two groups. Results 1 there was no significant difference in age, sex, disease process and color value before treatment between the two groups (P 0.05), and it was comparable. 2 the pigment value of the two groups after treatment was significantly lower than that before treatment (P 0.05). It is suggested that the pigmentation score of group A is significantly lower than that of group B at the 1st and 4th week after treatment (P 0.05), and the pigmentation score of group A is significantly lower than that of group B at the 1st and 4th week after treatment (P 0.05). The percentage of pigmented change in group A before and after treatment was significantly higher than that in group B (P 0.05). At the same time, the pigmentation time of group A was significantly shorter than that of group B (P 0.05), suggesting that the effect of external application of traditional Chinese medicine membrane was more obvious, and the residual time of pigment could be significantly shortened. 4 after treatment, 0 patients in group A were cured. 6 cases were markedly effective, 20 cases were effective and 4 cases were ineffective. The total effective rate was 86.7%. In group B, 0 cases were cured, 2 cases were markedly effective, 7 cases were effective and 21 cases were ineffective, the total effective rate was 30.0%. There was significant difference between the two groups (P 0.05). Conclusion the pigment left behind after mild burn can fade naturally. However, the external application of traditional Chinese medicine membrane combined with 2% hydrogen Kun can significantly shorten the time of pigment regression, improve the total effective rate of treatment, the treatment effect is obvious, at the same time, the adverse reactions are few, the patients' treatment compliance is high, and it is worth popularizing and applying in clinic.
【学位授予单位】：浙江中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R269

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