慢性阻塞性肺疾
发布时间：2019-06-15 17:55
【摘要】：目的:将已研制出的慢性阻塞性肺疾病(COPD)“病人报告结局”(PROs)中医评价量表应用于慢性阻塞性肺疾病稳定期患者及健康人,以对该量表的信度、效度、反应度等进行考评。方法:研究中,根据随机抽样、对照、重复、均衡等原则,严格遵照诊断标准、纳入标准,共收集慢性阻塞性肺疾病稳定期患者病例60例,分中药组和西药组(各30例),分别采用中医辨证综合治疗和西药治疗,28天为一疗程,治疗前后均用病人报告结局量表进行测评,并对患者进行生存质量量表的测定。另外,将采用病人报告结局量表对40例健康人进行测评以了解量表区分病人与健康人的能力。资料收集完后,采用SPSS17.0统计软件对资料进行统计处理,并对量表的可行性、效度、信度、反应度等进行考评。结果:1.量表的可行性:量表的接受率100%,回收率100%,问卷完成率为100%,条目完成率为100%,量表平均完成时间平均14.48±5.26分钟。2.量表的效度:内容效度:本量表由有关各方面人员参与选题与讨论,所提出的维度与条目内容充分体现了PROs量表的内涵及中医慢性阻塞性肺疾病稳定期有关病、证、症特点,并按程序化方式筛选条目,可认为具有较好的内容效度。结构效度:经探索性因子分析,测量结果与研究时研究者对量表构想的结构是相符的。效标效度:与WHOQOL-BREF相关系数为0.757,具有适度的相关性(P0.01)。3.量表的信度:总表与各维度的分半信度系数(R)均在0.66以上。总表及各维度的Cronbach’s alpha均在0.77以上。4.反应度:健康人各维度及总表得分的均数明显高于慢性阻塞性肺疾病稳定期患者的得分(p0.01)。慢性阻塞性肺疾病稳定期患者治前病人报告结局总表得分均数与标准差为100.30±12.212,治后为127.95±12.093,p0.01。治后各维度得分均数均有不同程度增加,提示各维度状态提高(p0.01)。治疗后各条目得分均数有不同程度的提高,各条目差异均有统计学意义(p0.05),其中中医证候维度条目变化较大,心理维度条目变化最小。中、西药组治疗前维度得分及总分相近,治后中药组症候、生理维度得分明显高于西药组(p0.05~0.01);提示中药在改善慢性阻塞性肺疾病稳定期患者的症候、生理等方面效果优于西药组。结论:1.本量表的接受率、回收率、完成率较高,完成时间不长,即量表的临床可行性好。2.本量表能区分不同人群(健康人与慢阻肺患者)、不同时间(治疗前后)生存质量的变化、不同干预措施所致不同疗效的能力,甚至能区分不同组别横向资料的差异及程度,对各条目资料得分的变化较为敏感,具有较好的反应度。3.效度、信度分析结果表明,本量表具有较好的内容效度、结构效度和适度的效标效度,维度相关性高;同时本量表具有较好的分半信度、同质性信度。提示本量表具有较好的效度和信度。
[Abstract]:Objective: to evaluate the reliability, validity and responsiveness of (COPD) "patient report outcome" (PROs) scale developed in stable stage of chronic obstructive pulmonary disease (COPD) and healthy people in order to evaluate the reliability, validity and responsiveness of the scale. Methods: according to the principles of random sampling, control, repetition and balance, 60 patients with stable chronic obstructive pulmonary disease (COPD) were collected according to the diagnostic criteria and included in the criteria. They were divided into Chinese medicine group (n = 30) and western medicine group (n = 30). The patients were treated with syndrome differentiation of traditional Chinese medicine (TCM) and western medicine for 28 days as a course of treatment. The quality of life scale was measured. In addition, 40 healthy people will be evaluated with the patient report outcome scale to understand the ability of the scale to distinguish patients from healthy people. After the data were collected, the data were statistically processed by SPSS17.0 statistical software, and the feasibility, validity, reliability and responsiveness of the scale were evaluated. Result: 1. The feasibility of the scale: the acceptance rate of the scale was 100%, the recovery rate was 100%, the completion rate of the questionnaire was 100%, the completion rate of items was 100%, and the average completion time of the scale was 14.48 卤5.26 minutes. The validity of the scale: content validity: the dimensions and items proposed in this scale fully reflect the connotation of PROs scale and the characteristics of diseases, syndromes and symptoms in the stable stage of chronic obstructive pulmonary disease (COPD), and screen the items according to the programmed way, which can be considered to have better content validity. Structural validity: through exploratory factor analysis, the measured results are consistent with the structure of the scale. Standard validity: the correlation coefficient with WHOQOL-BREF was 0.757, which had a moderate correlation (P01). 3. The reliability of the scale: the split-half reliability coefficient (R) of the total table and each dimension was above 0.66. The Cronbach's alpha of the summary table and each dimension is above 0.77. 4. The mean score of each dimension and total table of healthy people was significantly higher than that of patients with stable chronic obstructive pulmonary disease (p0.01). The average score and standard deviation of the total outcome table of patients with stable chronic obstructive pulmonary disease were 100.30 卤12.212, 127.95 卤12.09 3, p0.01. After treatment, the average score of each dimension increased to varying degrees, suggesting that the state of each dimension increased (p0.01). After treatment, the average score of each item was improved to some extent, and the difference of each item was statistically significant (p0.05). The item of TCM syndrome dimension changed greatly, and the change of psychological dimension item was the smallest. The scores of symptoms and physiological dimensions in the traditional Chinese medicine group were significantly higher than those in the western medicine group (p0.05 鈮，
本文编号：2500407
[Abstract]:Objective: to evaluate the reliability, validity and responsiveness of (COPD) "patient report outcome" (PROs) scale developed in stable stage of chronic obstructive pulmonary disease (COPD) and healthy people in order to evaluate the reliability, validity and responsiveness of the scale. Methods: according to the principles of random sampling, control, repetition and balance, 60 patients with stable chronic obstructive pulmonary disease (COPD) were collected according to the diagnostic criteria and included in the criteria. They were divided into Chinese medicine group (n = 30) and western medicine group (n = 30). The patients were treated with syndrome differentiation of traditional Chinese medicine (TCM) and western medicine for 28 days as a course of treatment. The quality of life scale was measured. In addition, 40 healthy people will be evaluated with the patient report outcome scale to understand the ability of the scale to distinguish patients from healthy people. After the data were collected, the data were statistically processed by SPSS17.0 statistical software, and the feasibility, validity, reliability and responsiveness of the scale were evaluated. Result: 1. The feasibility of the scale: the acceptance rate of the scale was 100%, the recovery rate was 100%, the completion rate of the questionnaire was 100%, the completion rate of items was 100%, and the average completion time of the scale was 14.48 卤5.26 minutes. The validity of the scale: content validity: the dimensions and items proposed in this scale fully reflect the connotation of PROs scale and the characteristics of diseases, syndromes and symptoms in the stable stage of chronic obstructive pulmonary disease (COPD), and screen the items according to the programmed way, which can be considered to have better content validity. Structural validity: through exploratory factor analysis, the measured results are consistent with the structure of the scale. Standard validity: the correlation coefficient with WHOQOL-BREF was 0.757, which had a moderate correlation (P01). 3. The reliability of the scale: the split-half reliability coefficient (R) of the total table and each dimension was above 0.66. The Cronbach's alpha of the summary table and each dimension is above 0.77. 4. The mean score of each dimension and total table of healthy people was significantly higher than that of patients with stable chronic obstructive pulmonary disease (p0.01). The average score and standard deviation of the total outcome table of patients with stable chronic obstructive pulmonary disease were 100.30 卤12.212, 127.95 卤12.09 3, p0.01. After treatment, the average score of each dimension increased to varying degrees, suggesting that the state of each dimension increased (p0.01). After treatment, the average score of each item was improved to some extent, and the difference of each item was statistically significant (p0.05). The item of TCM syndrome dimension changed greatly, and the change of psychological dimension item was the smallest. The scores of symptoms and physiological dimensions in the traditional Chinese medicine group were significantly higher than those in the western medicine group (p0.05 鈮，
本文编号：2500407
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