滇重楼巴布剂治疗急性痛风性关节炎的临床研究

发布时间：2019-06-25 08:36

【摘要】：目的:本研究应用滇重楼巴布剂外敷结合双氯芬酸钠缓释胶囊口服,观察并评价对治疗急性痛风性关节炎的临床疗效。以单纯口服双氯芬酸钠缓释胶囊作为参照,对比并评价与探讨两种方法的临床疗效差异,探讨滇重楼巴布剂的疗效和优势,尝试为弘扬中医药瑰宝、发掘云南道地药材、开发新型院内制剂提供一些决策参考和建议。方法:将2014年12月~2015年12月就诊于昆明市中医医院的符合纳入标准、疗程及随访观察完整的53例急性痛风性关节炎病例,按奇偶日期分类法(奇数日期就诊患者纳入对照组、偶数日期就诊患者纳入治疗组),对照组患者27例,治疗组患者26例,两组均服用双氯芬酸钠缓释胶囊,治疗组再外敷滇重楼巴布剂,对照组不采用任何外用药物,仅自行局部冷敷。通过定期观察、患者复查及随访方式,观察并记录关节红肿、肤温、疼痛、功能受限,血尿酸;以及局部瘙痒、红疹,肝功能(ALT、AST)、肾功能(Scr)等各项安全性指标。对采集数据进行统计学分析,评价两种不同治疗方法的临床疗效。结果:在本次治疗急性痛风性关节炎的临床疗效观察中,对照组和治疗组在1个疗程内对红肿热痛、活动功能均可有效的改善,在痛风性关节炎急性期,两组对降低尿酸无统计学意义;两组在疼痛、红肿、关节活动功能方面,治疗组的改善率明显高于对照组,差异有统计学意义;在改善关节肤温方面,两组相当,疗效的差异无统计学意义。结论:外敷滇重楼巴布剂配合常规口服双氯芬酸钠缓释胶囊较单纯口服双氯芬酸钠缓释胶囊在减轻关节疼痛、红肿、活动功能方面有明显改善;以及未发现外敷药所带来的局部、全身的副作用等症状,值得临床进一步推广运用。
[Abstract]:Objective: to observe and evaluate the clinical effect of Dianzhonglou cataplasma combined with diclofenac sodium sustained-release capsule in the treatment of acute gouty arthritis. Taking oral diclofenac sodium sustained release capsule as reference, this paper compares and evaluates and discusses the difference of clinical efficacy between the two methods, probes into the curative effect and advantages of Dianchonglou cataplasma, and tries to provide some decision-making references and suggestions for carrying forward the treasure of traditional Chinese medicine, excavating Yunnan Daodi medicinal materials and developing new in-hospital preparations. Methods: from December 2014 to December 2015, 53 cases of acute gouty arthritis were treated in Kunming Hospital of traditional Chinese Medicine from December 2014 to December 2015. 53 cases of acute gouty arthritis were classified according to odd date classification (odd date patients included in the control group and even number date patients into the treatment group). 27 patients in the control group and 26 patients in the treatment group were treated with diclofenac sodium sustained release capsule. The treatment group was treated with Dianzhonglou cataplasma, while the control group did not use any external drugs, only local cold compress. Through regular observation, patient reexamination and follow-up, the safety indexes such as joint redness and swelling, skin temperature, pain, limited function, blood uric acid, local pruritus, rash, liver function (ALT,AST) and renal function (Scr) were observed and recorded. The collected data were statistically analyzed to evaluate the clinical efficacy of two different treatment methods. Results: in the treatment of acute gouty arthritis, the control group and the treatment group could effectively improve the redness, swelling, heat pain and activity function in one course of treatment. In the acute stage of gouty arthritis, the two groups had no significant difference in reducing uric acid, but the improvement rate of the treatment group was significantly higher than that of the control group in the aspects of pain, redness and joint movement, the difference was statistically significant. In the aspect of improving joint skin temperature, the two groups were the same, and there was no significant difference in curative effect between the two groups. Conclusion: compared with oral diclofenac sodium sustained release capsule, external application of Dianzhonglou cataplasma combined with routine oral diclofenac sodium sustained release capsule has obvious improvement in reducing joint pain, redness and swelling and motor function, and no local and systemic side effects caused by external application are found, which is worthy of further clinical application.
【学位授予单位】：云南中医学院
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259

【相似文献】