顺气开郁化痰汤治疗反流性食管炎气郁痰阻证的临床研究
发布时间：2019-06-27 20:31
【摘要】：目的:探讨顺气开郁化痰汤治疗反流性食管炎气郁痰阻证的临床疗效及安全性。方法:选取湖南中医药大学第一附属医院消化内科门诊、胃镜室以及社会上招募的符合反流性食管炎诊断标准的志愿者,共纳入60例,其中治疗组30例,对照组30例。分别给予顺气开郁化痰汤和西药奥美拉唑、多潘立酮片,治疗8周,观察治疗前后临床症状及体征的改变,同时检测胃镜下食管粘膜的变化。结果:1.治疗组与对照组在治疗后总有效率分别为89.6%、71.4%,两组比较差异有统计学意义(P0.05),表明顺气开郁化痰汤在治疗气郁痰阻证反流性食管炎疗效优于单纯西药组。2.治疗前治疗组与对照组症状积分比较,差异无统计学意义(P0.05),具有齐同可比性;治疗后两组症状积分,与治疗前比较,差异均有统计学意义(P0.05),说明两组治疗均能改善RE气郁痰阻证患者的临床症状;而治疗后治疗组与对照组间比较,差异具有统计学意义(P0.05),表明顺气开郁化痰汤在改善RE气郁痰阻证患者症状优于对照组。3.治疗组可明显改善RE气郁痰阻证患者中医症候,特别对咽喉如痰梗,情志不畅加重、胸部不适、烧心、反酸、吞咽不利、神情忧郁症状疗效作用优于对照组。4.治疗前治疗组与对照组内镜积分比较,差异无统计学意义(P0.05),具有齐同可比性;治疗后两组内镜积分,与治疗前比较,差异均有统计学意义(P0.05),说明两组治疗均能改善RE患者内镜下食管粘膜的表现;而治疗后治疗组与对照组间比较,差异具有统计学意义(P0.05),表明顺气开郁化痰汤在改善RE患者内镜下食管粘膜的表现优于对照组。5.两组在治疗过程中均未出现不良反应,证明顺气开郁化痰汤治疗反流性食管炎气郁痰阻证安全有效。结论:顺气开郁化痰汤治疗反流性食管炎气郁痰阻证患者总有效率为89.6%,可明显改善反流性食管炎气郁痰阻证患者的中医临床症状,改善患者内镜下食管粘膜的表现。
[Abstract]:Objective: to investigate the clinical efficacy and safety of Shunqi Kaiyu Huatan decoction in the treatment of reflux esophagus. Methods: 60 volunteers recruited from the Department of Digestive Medicine, gastroscopy room and society in the first affiliated Hospital of Hunan University of traditional Chinese Medicine were enrolled in 60 volunteers, including 30 cases in the treatment group and 30 cases in the control group. Shunqi Kaiyu Huatan decoction and western medicine omeprazole and domperidone tablets were given respectively for 8 weeks to observe the changes of clinical symptoms and signs before and after treatment, and to detect the changes of esophageal mucosa under gastroscopy. Result: 1. After treatment, the total effective rates of the treatment group and the control group were 89.6% and 71.4%, respectively. there was significant difference between the two groups (P 0.05). The results showed that Shunqi Kaiyu Huatan decoction was superior to the western medicine group in the treatment of reflux esophagitis with syndrome of qi stagnation and phlegm obstruction. 2. Before treatment, there was no significant difference between the treatment group and the control group (P 0.05), and there was no significant difference between the treatment group and the control group (P 0.05). After treatment, the symptom scores of the two groups were significantly different from those before treatment (P 0.05), indicating that the treatment of the two groups could improve the clinical symptoms of RE patients with qi stagnation and phlegm obstruction syndrome. After treatment, there was significant difference between the treatment group and the control group (P 0.05), which indicated that Shunqi Kaiyu Huatan decoction was superior to the control group in improving the symptoms of RE patients with qi stagnation and phlegm obstruction syndrome. The treatment group could significantly improve the TCM symptoms of RE patients with qi stagnation and phlegm obstruction syndrome, especially for throat such as phlegm infarction, aggravation of emotion, chest discomfort, heartburn, acid regurgitation, dysphagia and melancholy. Before treatment, there was no significant difference between the treatment group and the control group (P 0.05), and there was no significant difference between the treatment group and the control group (P 0.05). After treatment, the endoscopic scores of the two groups were significantly different from those before treatment (P 0.05), indicating that the treatment of the two groups could improve the endoscopic esophageal mucosa performance of RE patients. After treatment, the difference between the treatment group and the control group was statistically significant (P 0.05), indicating that Shunqi Kaiyu Huatan decoction was superior to the control group in improving endoscopic esophageal mucosa in patients with RE. 5. There were no adverse reactions in both groups, which proved that Shunqi Kaiyu Huatan decoction was safe and effective in the treatment of reflux esophagus. Conclusion: the total effective rate of Shunqi Kaiyu Huatan decoction in the treatment of reflux esophagus with qi stagnation and phlegm obstruction syndrome is 89.6%, which can obviously improve the clinical symptoms of traditional Chinese medicine (TCM) and the endoscopic esophageal mucosa of patients with reflux esophagitis with qi stagnation and phlegm obstruction syndrome.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
本文编号：2507126
[Abstract]:Objective: to investigate the clinical efficacy and safety of Shunqi Kaiyu Huatan decoction in the treatment of reflux esophagus. Methods: 60 volunteers recruited from the Department of Digestive Medicine, gastroscopy room and society in the first affiliated Hospital of Hunan University of traditional Chinese Medicine were enrolled in 60 volunteers, including 30 cases in the treatment group and 30 cases in the control group. Shunqi Kaiyu Huatan decoction and western medicine omeprazole and domperidone tablets were given respectively for 8 weeks to observe the changes of clinical symptoms and signs before and after treatment, and to detect the changes of esophageal mucosa under gastroscopy. Result: 1. After treatment, the total effective rates of the treatment group and the control group were 89.6% and 71.4%, respectively. there was significant difference between the two groups (P 0.05). The results showed that Shunqi Kaiyu Huatan decoction was superior to the western medicine group in the treatment of reflux esophagitis with syndrome of qi stagnation and phlegm obstruction. 2. Before treatment, there was no significant difference between the treatment group and the control group (P 0.05), and there was no significant difference between the treatment group and the control group (P 0.05). After treatment, the symptom scores of the two groups were significantly different from those before treatment (P 0.05), indicating that the treatment of the two groups could improve the clinical symptoms of RE patients with qi stagnation and phlegm obstruction syndrome. After treatment, there was significant difference between the treatment group and the control group (P 0.05), which indicated that Shunqi Kaiyu Huatan decoction was superior to the control group in improving the symptoms of RE patients with qi stagnation and phlegm obstruction syndrome. The treatment group could significantly improve the TCM symptoms of RE patients with qi stagnation and phlegm obstruction syndrome, especially for throat such as phlegm infarction, aggravation of emotion, chest discomfort, heartburn, acid regurgitation, dysphagia and melancholy. Before treatment, there was no significant difference between the treatment group and the control group (P 0.05), and there was no significant difference between the treatment group and the control group (P 0.05). After treatment, the endoscopic scores of the two groups were significantly different from those before treatment (P 0.05), indicating that the treatment of the two groups could improve the endoscopic esophageal mucosa performance of RE patients. After treatment, the difference between the treatment group and the control group was statistically significant (P 0.05), indicating that Shunqi Kaiyu Huatan decoction was superior to the control group in improving endoscopic esophageal mucosa in patients with RE. 5. There were no adverse reactions in both groups, which proved that Shunqi Kaiyu Huatan decoction was safe and effective in the treatment of reflux esophagus. Conclusion: the total effective rate of Shunqi Kaiyu Huatan decoction in the treatment of reflux esophagus with qi stagnation and phlegm obstruction syndrome is 89.6%, which can obviously improve the clinical symptoms of traditional Chinese medicine (TCM) and the endoscopic esophageal mucosa of patients with reflux esophagitis with qi stagnation and phlegm obstruction syndrome.
【学位授予单位】：湖南中医药大学
【学位级别】：硕士
【学位授予年份】：2016
【分类号】：R259
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1 李田田;顺气开郁化痰汤治疗反流性食管炎气郁痰阻证的临床研究[D];湖南中医药大学;2016年
，本文编号：2507126
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