丹芪祛瘀止痛颗粒对气虚血瘀型胃癌前病变患者胃黏膜组织TRAF1、4-1BB、Bcl-xL表达的影响

发布时间：2019-07-01 13:24

【摘要】：目的观察丹芪祛瘀止痛颗粒治疗气虚血瘀型胃癌前病变患者的临床疗效及可能作用机制。方法将68例气虚血瘀型胃癌前病变患者随机分为治疗组和对照组各34例。治疗组给予丹芪祛瘀止痛颗粒,每次10g,每天3次。对照组给予维酶素片,每次0.8 g,每天3次。两组疗程均为3个月。治疗后评价临床疗效,治疗前后分别对患者中医症状、胃黏膜组织病理进行评分,并检测胃黏膜组织中肿瘤坏死因子受体相关因子1(TRAF1)、淋巴细胞活化诱导受体(4-1BB)及白细胞淋巴瘤/白血病xL(Bcl-xL)的表达。结果治疗组临床疗效总有效率为85.29%,对照组为58.82%,治疗组明显高于对照组(P0.05)。两组患者治疗后中医症状评分、胃黏膜组织病理评分均较本组治疗前明显下降,且治疗组均明显低于对照组(P0.05或P0.01)。治疗后治疗组胃黏膜组织中TRAF1、4-1BB、Bcl-xL表达明显下降,对照组TRAF1表达明显下降,且治疗组TRAF1、4-1BB、Bcl-xL表达均明显低于对照组(P0.05或P0.01)。结论丹芪祛瘀止痛颗粒可明显改善气虚血瘀型胃癌前病变患者胃黏膜组织病理情况,其机制可能与下调胃黏膜组织中TRAF1、4-1BB、Bcl-xL表达水平有关。
[Abstract]:Objective to observe the clinical effect and possible mechanism of Danqi Quyu Zhitong granule in the treatment of precancerous lesions of gastric cancer with qi deficiency and blood stasis. Methods Sixty-eight patients with precancerous lesions of gastric cancer with qi deficiency and blood stasis were randomly divided into treatment group (n = 34) and control group (n = 34). The treatment group was given Danqi Quyu Zhitong granule, 10 g each time, 3 times a day. The control group was given viritin tablets 0.8 g each time, 3 times a day. The course of treatment in both groups was 3 months. The clinical efficacy was evaluated after treatment. The symptoms of traditional Chinese medicine (TCM) and the pathology of gastric mucosa were evaluated before and after treatment. The expression of tumor necrosis factor receptor related factor 1 (TRAF1), lymphocyte activation induced receptor (4-1BB) and leukocytic lymphoma / leukemia xL (Bcl-xL) in gastric mucosa were detected. Results the total effective rate was 85.29% in the treatment group and 58.82% in the control group, which was significantly higher in the treatment group than in the control group (P 0.05). After treatment, the scores of TCM symptoms and gastric mucosa pathology in the two groups were significantly lower than those before treatment, and the scores in the treatment group were significantly lower than those in the control group (P 0.05 or P 0.01). After treatment, the expression of TRAF1,4-1BB,Bcl-xL in gastric mucosa of the treatment group was significantly decreased, the expression of TRAF1 in the control group was significantly decreased, and the expression of TRAF1,4-1BB,Bcl-xL in the treatment group was significantly lower than that in the control group (P 0.05 or P 0.01). Conclusion Danqi Quyu Zhitong granule can obviously improve the pathological situation of gastric mucosa in patients with gastric precancerous lesion of qi deficiency and blood stasis type, and its mechanism may be related to the down-regulation of TRAF1,4-1BB,Bcl-xL expression in gastric mucosa.
【作者单位】： 黑龙江省中医药科学院南岗分院;
【基金】：国家中医药管理局中医药科学技术研究专项(2016ZX05) 黑龙江省科技计划(GC12C110) 黑龙江省博士后科研启动基金(LBH-Q13156)
【分类号】：R259
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本文编号：2508514