肝主疏泄的源流追溯及现代研究

发布时间：2019-07-10 10:46

【摘要】：一直以来,中医学术界在对待"肝主疏泄"的源流问题上意见纷纭。追溯其源流,"疏泄"一词最早见于《黄帝内经》(以下简称《内经》),在《说文解字》中也能找到肝主疏泄的影子。其后经历金元时期"相火论"的影响,明清时期医家对该理论内涵的不断外延补充,新中国时期肝主疏泄最终被确立为肝的生理功能之一并被写入教材。现代西医研究为肝主疏泄的5个主要内涵提供了合理性解释,海马区与情绪控制密切相关也被证实为疏肝解郁药的主要靶区。此外,肝主疏泄的功能可能是调节脑肠肽的核心,而肝主疏泄可以通过影响人体内分泌系统调节人体生殖。
[Abstract]:For the long time, the academic circle of the Chinese medicine has been on the subject of the source of the "liver primary drainage". To trace its origin, the word "drainage" is first seen in the Yellow Emperor's Classic of Internal Medicine (hereinafter referred to as the "Neijing"), and the shadow of the main relief of the liver can also be found in the words of "Shuo Wen Jie Zi". After that, the influence of the "phase-fire theory" of the Jin-yuan period and the continuous extension of the connotation of the theory in the period of the Ming and Qing Dynasties, the main relief of the liver in the new China was finally established as one of the physiological functions of the liver and was written into the teaching material. The study of the modern western medicine provides a rational explanation for the five main contents of the main relief of the liver, and the hippocampus is closely related to the emotional control and is also proved to be the main target area for soothing the liver. In addition, the function of liver primary drainage may be the core of the regulation of the brain-intestinal peptide, and the liver-primary drainage can regulate the human reproduction by affecting the human endocrine system.
【作者单位】：南方医科大学;
【基金】：2014年度南方医科大学校级大学生创新创业训练计划(201412121144)-“肝主疏泄”的源流研究 2015年广东省中医药局科研课题(20151299)-桂枝甘草龙骨牡蛎汤对失眠的调控机制研究 2015年度南方医科大学校级大学生创新创业训练计划(2501512121154)-RhoB表达变化对肝癌转移的临床意义 2016年广东省自然科学基金项目(2016A030313596)-Rho/ROCK信号通路在肝癌转移侵袭中的调控机制及中药的干预作用广东省自然科学基金资助项目(2014A030313332) 国家自然科学基金(81603427)-ROCK在TGF-β1/CTGF信号通路调控肝癌血管生成拟态中的分子机制及中药的干预作用
【分类号】：R223

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