口炎清颗粒治疗慢性牙周炎的临床观察
发布时间：2019-07-31 10:38
【摘要】：目的:观察口炎清颗粒治疗慢性牙周炎的疗效、安全性及对炎性细胞因子的影响。方法:110例慢性牙周炎患者随机分为对照组(55例)和观察组(55例)。对照组患者接受详细的口腔卫生指导、全口龈上洁治、龈下刮治和根面平整等常规治疗;观察组患者在对照组治疗的基础上给予口炎清颗粒20 g,开水冲服,每日2次。两组疗程均为4周。观察两组患者的临床疗效,治疗前后菌斑指数(PLI)、牙龈指数(GI)、牙周探诊深度(PD)、临床附着水平(CAL)、白细胞介素17(IL-17)和IL-21水平及不良反应发生情况。结果:两组患者均完成治疗,无失访患者。观察组患者总有效率显著高于对照组,差异有统计学意义(P0.05)。治疗后,两组患者PLI、GI、PD、CAL、IL-17和IL-21水平均显著低于同组治疗前,且观察组显著低于对照组,差异均有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:在常规治疗的基础上,口炎清颗粒治疗慢性牙周炎的疗效显著,可显著改善牙周症状,降低炎性细胞因子水平,且未增加不良反应的发生。
[Abstract]:Objective: to observe the efficacy and safety of Kouyanqing granule in the treatment of chronic periodontitis and its effect on inflammatory cytokines. Methods: 110 patients with chronic periodontitis were randomly divided into control group (55 cases) and observation group (55 cases). The patients in the control group received detailed oral hygiene guidance, subgingival cleaning, subgingival curettage and root leveling, while the patients in the observation group were given Kouyanqing granule 20 g, boiled water twice a day, on the basis of the treatment in the control group. The course of treatment in both groups was 4 weeks. To observe the clinical efficacy of the two groups, the plaque index (PLI), gum index (GI), periodontal probing depth (PD), clinical attachment level (CAL), IL-17 (IL-17) and IL-21 levels and the occurrence of adverse reactions before and after treatment. Results: both groups of patients completed the treatment, no lost follow-up patients. The total effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P 0.05). After treatment, the levels of PLI,GI,PD,CAL,IL-17 and IL-21 in the two groups were significantly lower than those in the same group before treatment, and the levels in the observation group were significantly lower than those in the control group (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: on the basis of routine treatment, Kouyanqing granule is effective in the treatment of chronic periodontitis, which can significantly improve periodontal symptoms, reduce the level of inflammatory cytokines, and does not increase the occurrence of adverse reactions.
【作者单位】： 西南医科大学口腔医学院 西南医科大学附属口腔医院
【分类号】：R276.8
[Abstract]:Objective: to observe the efficacy and safety of Kouyanqing granule in the treatment of chronic periodontitis and its effect on inflammatory cytokines. Methods: 110 patients with chronic periodontitis were randomly divided into control group (55 cases) and observation group (55 cases). The patients in the control group received detailed oral hygiene guidance, subgingival cleaning, subgingival curettage and root leveling, while the patients in the observation group were given Kouyanqing granule 20 g, boiled water twice a day, on the basis of the treatment in the control group. The course of treatment in both groups was 4 weeks. To observe the clinical efficacy of the two groups, the plaque index (PLI), gum index (GI), periodontal probing depth (PD), clinical attachment level (CAL), IL-17 (IL-17) and IL-21 levels and the occurrence of adverse reactions before and after treatment. Results: both groups of patients completed the treatment, no lost follow-up patients. The total effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P 0.05). After treatment, the levels of PLI,GI,PD,CAL,IL-17 and IL-21 in the two groups were significantly lower than those in the same group before treatment, and the levels in the observation group were significantly lower than those in the control group (P 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P 0.05). Conclusion: on the basis of routine treatment, Kouyanqing granule is effective in the treatment of chronic periodontitis, which can significantly improve periodontal symptoms, reduce the level of inflammatory cytokines, and does not increase the occurrence of adverse reactions.
【作者单位】： 西南医科大学口腔医学院 西南医科大学附属口腔医院
【分类号】：R276.8
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