左归疏肝汤加减治疗多囊卵巢综合征不孕症的临床疗效研究

发布时间：2019-07-31 12:01

【摘要】：目的探讨左归疏肝汤加减治疗多囊卵巢综合征(PCOS)不孕症的临床疗效。方法选取2014年6月—2016年3月在浙江中医药大学附属第二医院妇科门诊首次就诊的PCOS患者150例,采用随机数字表法分为对照组和试验组各75例。对照组患者采用克罗米芬治疗,试验组患者在对照组的治疗基础上服用左归疏肝汤加减治疗,当直径1.4 cm的卵泡数≥3个时停止治疗,两组的治疗和观察周期不超过6个月。比较两组患者的血清内分泌生殖激素水平、排卵和妊娠情况、临床疗效及不良反应发生率。结果治疗前两组患者血清黄体生成素(LH)、卵泡刺激素(FSH)、睾酮(T)水平比较,差异无统计学意义(P0.05);治疗后试验组患者血清LH、FSH、T水平低于对照组,差异有统计学意义(P0.05)。治疗后对照组患者血清LH、FSH水平低于治疗前,试验组患者血清LH、FSH、T水平低于治疗前,差异有统计学意义(P0.05);而对照组患者血清T水平与治疗前比较,差异无统计学意义(P0.05)。试验组患者优势卵泡出现率、排卵率、临床妊娠率高于对照组,差异有统计学意义(P0.05);两组患者早期流产率比较,差异无统计学意义(P0.05)。试验组患者临床疗效优于对照组,差异有统计学意义(P0.05)。两组患者子宫内膜变薄、卵巢过度刺激综合征发生率比较,差异无统计学意义(P0.05)。结论在服用克罗米芬的基础上采用左归疏肝汤加减治疗,可以有效降低PCOS不孕症患者的内分泌生殖激素水平,提高优势卵泡出现率、排卵率及临床妊娠率,疗效确切。
[Abstract]:Objective to investigate the clinical effect of Zuogui Shugan decoction in the treatment of (PCOS) sterility in polycystic ovary syndrome (PCOS). Methods from June 2014 to March 2016, 150 patients with PCOS were enrolled in the gynecological clinic of the second affiliated Hospital of Zhejiang University of traditional Chinese Medicine. 75 patients in the control group and 75 patients in the experimental group were randomly divided into control group (n = 75) and experimental group (n = 75). The patients in the control group were treated with clomiphene, and the patients in the experimental group were treated with Zuogui Shugan decoction on the basis of the treatment in the control group. When the number of follicles in diameter of 1.4 cm was 鈮，

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