基于SEM的胃癌化疗后辨证标准的生物学指标探讨

发布时间：2019-08-16 07:51

【摘要】：目的利用SEM结构方程模型探讨胃癌化疗后的中医证候分型与相关生物学指标之间的联系。方法采集胃癌化疗后的不同证型患者的中医宏观四诊信息和西医检测指标(如血常规、肝肾功、肿瘤标志物、超声、CT、MRI等),并以其为自变量,通过探索性因子分析构建中医辨证初始模型,后以中医证型为潜变量,以四诊信息及检测指标为外显变量,探索验证生物学指标与辨证标准之间对应关系的结构方程模型。结果分别获得了五个个体辨证模型及群体验证模型,并获得了五个模型相应的生物学指标,并进行了验证。结论构建了胃癌化疗后的个体、群体的综合辨证结构模型,并通过评价模型拟合的优劣验证了含有相关生物指标的辨证标准,为其它疾病及潜证辨证标准研究提供科学的依据。
[Abstract]:Objective to investigate the relationship between TCM syndrome classification and related biological indexes of gastric cancer after chemotherapy by using SEM structural equation model. Methods the macro four diagnosis information of traditional Chinese medicine and the detection indexes of western medicine (such as blood routine, liver and kidney function, tumor markers, ultrasound, CT,MRI, etc.) were collected from different syndrome types of gastric cancer after chemotherapy, and the initial model of TCM syndrome differentiation was constructed by exploratory factor analysis, and then the syndrome type of traditional Chinese medicine was taken as latent variable, and the four diagnosis information and detection index were taken as explicit variables. To explore the structural equation model to verify the corresponding relationship between biological indexes and syndrome differentiation criteria. Results five individual syndrome differentiation models and group verification models were obtained, and the corresponding biological indexes of the five models were obtained and verified. Conclusion the comprehensive syndrome differentiation structure model of individual and group after chemotherapy of gastric cancer is constructed, and the syndrome differentiation standard containing relevant biological indexes is verified by evaluating the fitting of the model, which provides a scientific basis for the study of syndrome differentiation criteria of other diseases and latent syndromes.
【作者单位】：陕西中医药大学附属医院;陕西中医药大学;甘肃省武威市中医医院;甘肃省酒泉地区医院;甘肃省金昌市人民医院;
【基金】：国家自然科学基金(No.81102561) 陕西省自然科学基金资助课题(No.2014JM2-8158)
【分类号】：R273

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