补肾化瘀胶囊治疗黄褐斑的临床效果及其作用机制

发布时间：2019-08-16 10:04

【摘要】：目的:探讨补肾化瘀胶囊治疗黄褐斑的临床效果及其作用机制。方法:选取2014年3月~2016年2月本院皮肤科门诊收治的60例黄褐斑患者进行研究,根据就诊号随机分为补肾化瘀组(观察组)、六味地黄丸组各30例(对照组),两组均结合常规治疗方法进行治疗,30天为一个疗程,连续治疗6个疗程后进行临床效果、实验指标评价。结果:治疗后,两组患者的皮损面积评分、皮损颜色评分、皮损颜色均一性评分、MASI评分较治疗前均显著的降低,观察组的皮损面积评分、皮损颜色评分、皮损颜色均一性评分、MASI评分均明显低于对照组。治疗后,观察组的含药血清黑色素、酪氨酸酶活性测定值分别为(1.31±0.01和1.24±0.01),均明显低于对照组(1.44±0.02和1.31±0.02)。治疗后,观察组的愈显率为76.67%,高于对照组的50.00%,但观察组的总有效率为96.67%,与对照组86.67%相比,差异无统计学意义。结论:补肾化瘀胶囊可降低黄褐斑患者血清中黑色素水平、酪氨酸酶活性,从而更好的发挥治疗黄褐斑的效果。
[Abstract]:Objective: to investigate the clinical effect and mechanism of Bushen Huayu capsule in the treatment of chloasma. Methods: from March 2014 to February 2016, 60 patients with chloasma were randomly divided into two groups: Bushen Huayu group (observation group) and Liuwei Dihuang pill group (control group). Both groups were treated with routine treatment for 30 days as a course of treatment, and the clinical effect was evaluated after 6 consecutive courses of treatment. Results: after treatment, the skin lesion area score, skin color uniformity score and MASI score of the two groups were significantly lower than those before treatment. The skin lesion area score, skin lesion color uniformity score and MASI score of the observation group were significantly lower than those of the control group. After treatment, the activities of melanin and tyrosinase in serum of the observation group were (1.31 卤0.01) and 1.24 卤0.01, respectively, which were significantly lower than those of the control group (1.44 卤0.02 and 1.31 卤0.02). After treatment, the effective rate of the observation group was 76.67%, which was higher than that of the control group (50.00%), but the total effective rate of the observation group was 96.67%, which was not significantly different from that of the control group (86.67%). Conclusion: Bushen Huayu capsule can reduce the level of melanin and the activity of tyrosinase in serum of patients with chloasma, so as to give full play to the effect of treatment of chloasma.
【作者单位】：南阳市中心医院;
【基金】：2011年度南阳市科技计划项目,编号:2011164-18Z
【分类号】：R275.9

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