多体素~1H-MRS推断不同温度下死亡时间的研究

发布时间：2018-03-11 15:47

本文选题：法医病理学　切入点：死亡时间推断　出处：《中国法医学杂志》2008年06期 　论文类型：期刊论文

【摘要】：目的利用多体素质子磁共振波谱(1H-MRS)技术推断不同温度下的死亡时间。方法选取24只白兔,分为两组,利用多体素质子磁共振波谱测定死后30m in、1h、2h、4h、6h、8h、12h、16h、24h脑内N-乙酰天门冬氨酸、胆碱复合物、磷酸肌酸和肌酸各代谢物之间峰下面积的比值。结果死后24h内N-乙酰天门冬氨酸与磷酸肌酸和肌酸的比值随死亡时间的延长而降低,胆碱复合物与磷酸肌酸和肌酸的比值随死亡时间的延长而升高。Naa/Cr、Ch/Cr与PM I进行回归分析:自变量为Naa/Cr的二次多项式方程为:y=0.0020x2-0.0815x+1.4532(R2=0.971);自变量为Ch/Cr的二次多项式方程为:y=-0.0024x2+0.0870x+1.1876(R2=0.962)。用Naa/Cr的方程推测PM I,当PM I24h时,平均偏离时间为1.70~50.27m in,用Ch/Cr的方程推测PM I,当PM I24h时,平均偏离时间为1.12~98.11m in。结论Naa/Cr、Ch/Cr的死后变化与时间呈强相关性,可用于死亡时间推断。
[Abstract]:Objective to estimate the death time of 24 rabbits at different temperatures by using multibody quality subtractive magnetic resonance spectroscopy (MRS). Methods 24 rabbits were divided into two groups, and their brain N- acetyl aspartic acid (Nacetyl aspartic acid) was determined by multibody quality subtractive magnetic resonance spectroscopy (MRS) at 30 min ~ 1 h ~ 1 h ~ 2 h ~ 2 h ~ 4 h ~ 6 h ~ 6 h ~ 6 h ~ (12) h ~ (12) h ~ (12) h ~ 1 ~ (16) h ~ (-1) ~ 24 h. The ratio of subpeak area between choline complex, creatine phosphate and creatine metabolites. Results the ratio of N- acetyl aspartate to creatine phosphate and creatine decreased with the prolongation of death time within 24 hours after death. The ratio of choline complex to creatine phosphate and creatine increases with the prolongation of the time of death. The regression analysis of na / Cr / Cr and PM shows that the quadratic polynomial equation of independent variable Naa/Cr is: 1: 0.0020x2-0.0815x 1.4532u R2O0.971N; the quadratic polynomial equation of independent variable Ch/Cr is: yyyang-0.0024x2 0.0870x. 1.1876 ~ R2 ~ (2 +) 0.962ng. using the equation of Naa/Cr to infer PM I, when PM I is 24 h, The average deviation time was 1.70 ~ 50.27 min, and the average deviation time was 1.12 ~ 98.11 min when PM I was 24 h. Conclusion there is a strong correlation between the postmortem variation and the time of death of Na / Cr / Cr / Cr, which can be used to estimate the death time.
【作者单位】：华中科技大学同济医学院法医学系;中国政法大学证据科学教育部重点实验室;华中科技大学同济医学院附属同济医院放射科;
【分类号】：D919

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