DNA遗传标记的法医学应用参数计算软件的开发
发布时间：2018-09-07 13:01
【摘要】： 前言 随着科技的发展,计算机技术已经逐步渗透到人们生活的各个领域。这种技术在法医学中最主要的应用是法医DNA数据库,这种软件主要用于侦破各种案件以及串并案。此外另一种适用于鉴定中心使用的亲子鉴定管理软件也有很高的实用价值,这种软件主要实现对于各种亲权指数以及基础性研究中参数的计算,用于对于物证分型结果进行解释和量化,从而得出科学的鉴定结论,为亲权鉴定工作提供有力支持。 目前,各种各样的亲子鉴定管理软件被相继开发出来,国外比较有代表性的比如DNA-VIEWER,该软件可以在Windows XP, Vista,98,或DOS系统上运行,可以用于犯罪鉴定,亲子鉴定,灾难鉴定和科学研究。国内也有四川华西医科大学法医学院等机构开发出相应的软件,实现亲子鉴定计算,案件信息存储等功能。但国内的国内的软件与国外的软件在功能结构上比较相对简单,功能局限,很多软件基因频率存储并不是在数据库中,因而不能根据地区民族存储和利用数据。大多需要完全借助第三方软件实现打印功能,不能实现频率调查研究中DP,PE值的相关计算功能。 有鉴于此本研究采用当前最流行的编程语言之一JAVA以及window操作系统自带的access数据库,结合概率论及数理统计中相关算法原理开发出一套适合于亲子鉴定工作使用的,界面使用方便,可进行亲权指数计算,及案件信息存储,实验结果以及鉴定报告打印的法医学亲子鉴定管理软件。 材料和方法 1、硬件平台：奔腾2.88G双核,512M内存配置电脑一台。 2、软件平台：WINDOWS XP操作系统、JAVA编程语言、access数据库、exej4外包软件。 3、计算方法：标准三联体,单亲二联体,双亲皆疑三联体中各种等位基因分型情况下的PI值,以及累计的CPI值,RCP值计算公式.身份识别Pm,DP计算公式.遗传标记频率调查中基因频率,基因型频率,DP值,PE值,杂合度计算公式。 实现功能 1、实现了对不同地区民族等位基因频率与等位基因分型频率的动态存储和删除。可将相关文献摘录的数据保存到数据库中。 2、频率调查研究中,基因频率,基因型频率,DP(个人识别率),PE(非父排除率),H(杂合度)的计算。并将计算得到的基因频率,基因型频率存储到数据库中。 3、案件信息的存储,包括委托人信息,当事人信息,以及案件使用等位基因遗传标记以及分型情况,计算结果的存储。 4、根据姓名进行案件编号查询,根据案件编号进行案件相关信息恢复,删除功能。根据年份进行不同类型案件例数统计的功能。 5、亲权鉴定中标准三联体,标准二联体,双亲皆疑三联体的PI, CPI, RCP的计算以及基因位点任意定义的功能。身份识别中DP, TDP的计算以及基因位点任意定义的功能。将输入数据与计算结果显示在同一界面上,并对每个位点给出相应的PI值。 6、打印功能,包括计算结果表格打印和鉴定报告打印两部分。 结论 使用JAVA编程语言与Access数据库相结合,开发出适合法医物证鉴定中心使用的亲子鉴定管理软件。进行亲子鉴定计算和案件信息管理,更好的为亲子鉴定工作服务。
[Abstract]:Preface
With the development of science and technology, computer technology has gradually penetrated into all areas of people's lives. The most important application of this technology in forensic medicine is forensic DNA database. This software is mainly used to detect various cases and concurrent cases. In addition, another kind of parentage identification management software which is suitable for the identification center also has a high degree of reality. With value, this software mainly realizes the calculation of various parentage indices and parameters in basic research, which can be used to interpret and quantify the results of physical evidence typing, so as to draw scientific conclusions and provide strong support for parentage identification.
At present, a variety of paternity testing management software has been developed, such as DNA-VIEWER, which can be run on Windows XP, Vista, 98, or DOS system. It can be used in crime identification, paternity identification, disaster identification and scientific research. But the domestic software and the foreign software are relatively simple in function structure and function limitation, many software gene frequency storage is not in the database, therefore can not store and use the data according to the region nationality. Help third party software realize printing function, can not achieve the frequency investigation and study of DP, PE value related calculation function.
In view of this, this research uses JAVA, one of the most popular programming languages, and access database of Windows operating system, and combines the theory of probability and the related algorithm principle of mathematical statistics to develop a set of suitable for parent-child identification. The interface is easy to use, and it can be used to calculate the parental index, and the case information storage, experimental results. The forensic paternity management software is printed in the identification report.
Materials and methods
1, hardware platform: Pentium 2.88G dual core, 512M memory configuration computer.
2, software platform: WINDOWS XP operating system, JAVA programming language, access database, exej4 outsourcing software.
3. Calculation methods: The PI values of standard triplet, uniparental diploid, and parental suspected triploid, as well as the cumulative CPI values and RCP values calculation formulas. Identification Pm, DP calculation formulas. Gene frequency, genotype frequency, DP value, PE value, heterozygosity calculation formulas in genetic marker frequency survey.
Implement function
1. The dynamic storage and deletion of allele frequencies and allele typing frequencies for different ethnic groups in different regions are realized. The data extracted from relevant literatures can be stored in a database.
2. Gene frequencies, genotype frequencies, DP (personal identification rate), PE (non-paternity exclusion rate), H (heterozygosity) were calculated in the frequency survey. The calculated gene frequencies and genotype frequencies were stored in the database.
3. Storage of case information, including client information, party information, and the use of allele genetic markers and typing of cases, the storage of calculation results.
4, according to the name of the case number inquiry, according to the case number of the case related information recovery, deletion function.
5. The calculation of PI, CPI, RCP and the function of arbitrary definition of gene locus in paternity testing. The calculation of DP, TDP and the function of arbitrary definition of gene locus in identification. The input data and calculation results are displayed on the same interface, and the corresponding PI values for each locus are given.
6, printing function, including calculation result table printing and identification report printing two parts.
conclusion
With the combination of JAVA programming language and Access database, a paternity testing management software suitable for forensic material evidence appraisal center is developed. The paternity testing calculation and case information management are carried out to better serve the work of paternity testing.
【学位授予单位】：中国医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：D919
[Abstract]:Preface
With the development of science and technology, computer technology has gradually penetrated into all areas of people's lives. The most important application of this technology in forensic medicine is forensic DNA database. This software is mainly used to detect various cases and concurrent cases. In addition, another kind of parentage identification management software which is suitable for the identification center also has a high degree of reality. With value, this software mainly realizes the calculation of various parentage indices and parameters in basic research, which can be used to interpret and quantify the results of physical evidence typing, so as to draw scientific conclusions and provide strong support for parentage identification.
At present, a variety of paternity testing management software has been developed, such as DNA-VIEWER, which can be run on Windows XP, Vista, 98, or DOS system. It can be used in crime identification, paternity identification, disaster identification and scientific research. But the domestic software and the foreign software are relatively simple in function structure and function limitation, many software gene frequency storage is not in the database, therefore can not store and use the data according to the region nationality. Help third party software realize printing function, can not achieve the frequency investigation and study of DP, PE value related calculation function.
In view of this, this research uses JAVA, one of the most popular programming languages, and access database of Windows operating system, and combines the theory of probability and the related algorithm principle of mathematical statistics to develop a set of suitable for parent-child identification. The interface is easy to use, and it can be used to calculate the parental index, and the case information storage, experimental results. The forensic paternity management software is printed in the identification report.
Materials and methods
1, hardware platform: Pentium 2.88G dual core, 512M memory configuration computer.
2, software platform: WINDOWS XP operating system, JAVA programming language, access database, exej4 outsourcing software.
3. Calculation methods: The PI values of standard triplet, uniparental diploid, and parental suspected triploid, as well as the cumulative CPI values and RCP values calculation formulas. Identification Pm, DP calculation formulas. Gene frequency, genotype frequency, DP value, PE value, heterozygosity calculation formulas in genetic marker frequency survey.
Implement function
1. The dynamic storage and deletion of allele frequencies and allele typing frequencies for different ethnic groups in different regions are realized. The data extracted from relevant literatures can be stored in a database.
2. Gene frequencies, genotype frequencies, DP (personal identification rate), PE (non-paternity exclusion rate), H (heterozygosity) were calculated in the frequency survey. The calculated gene frequencies and genotype frequencies were stored in the database.
3. Storage of case information, including client information, party information, and the use of allele genetic markers and typing of cases, the storage of calculation results.
4, according to the name of the case number inquiry, according to the case number of the case related information recovery, deletion function.
5. The calculation of PI, CPI, RCP and the function of arbitrary definition of gene locus in paternity testing. The calculation of DP, TDP and the function of arbitrary definition of gene locus in identification. The input data and calculation results are displayed on the same interface, and the corresponding PI values for each locus are given.
6, printing function, including calculation result table printing and identification report printing two parts.
conclusion
With the combination of JAVA programming language and Access database, a paternity testing management software suitable for forensic material evidence appraisal center is developed. The paternity testing calculation and case information management are carried out to better serve the work of paternity testing.
【学位授予单位】：中国医科大学
【学位级别】：硕士
【学位授予年份】：2010
【分类号】：D919
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