中药膜技术的“绿色制造”特征、国家战略需求及其关键科学问题与应对策略

发布时间：2018-07-02 10:06

本文选题：中医药 + 国家科技战略　；参考：《中草药》2017年16期

【摘要】：中医药是我国具有原创优势的科技领域,中医药继承创新研究已被提升为国家科技战略。膜技术适应中药药效物质整体、多元特征的优势,可充分实现中药资源的核心价值;并具高效、节能、无污染等特点。中医药膜科技具有重大国家科技战略需求,是我国中药制药工业亟需推广的高新技术。紧密围绕膜技术在中药制药工业的产业化应用,对所开展的中药绿色制造关键技术研究——"基于膜过程的中药制药分离工程技术体系与应用"进行概述,针对中药工业生产中制剂前处理环节存在的生产效率低、药材利用率低、能耗大、污染高、灭菌效率低等共性问题,基于中成药生产过程特点、工程原理和规律,以膜科学技术为核心,通过构建"中药溶液环境"科学假说,引进复杂系统科学原理,建立基于计算机化学方法的中药膜传质过程研究方法;针对中药膜技术工程化应用瓶颈,构建面向中药物料的"膜过程优化"技术集成等策略,开展中成药生产中节能、降耗、减排、工艺优化等关键技术与装备的研发,形成基于膜过程的具有自主知识产权的中药绿色制造系列关键共性技术,建立符合中药特点的环境友好生产线,实现了中药工业生产中制剂前处理"提取、精制、浓缩"等环节的高效、环保、稳定与智能控制。中药膜技术以水为基本溶剂,可保留中医传统用药特色,所研制的膜技术及其成套设备已推广至全国29个省市,产生了显著的社会和经济效益。膜技术完全符合建设资源节约型和环境友好型社会,以及循环经济的发展思路,是名副其实的中药绿色制造关键技术,对推动我国中药制药行业的技术进步,提升劳动生产率和资源利用率具有重要作用,具有广阔的推广应用前景。
[Abstract]:Traditional Chinese medicine (TCM) is an original science and technology field in China, and the research of Chinese medicine inheritance and innovation has been promoted to national science and technology strategy. The membrane technology can fully realize the core value of traditional Chinese medicine resources and has the characteristics of high efficiency, energy saving, no pollution and so on. Membrane science and technology of traditional Chinese medicine (TCM) has great strategic demand of national science and technology, which is a high and new technology that needs to be popularized in Chinese medicine industry. Focusing on the application of membrane technology in the industrialization of traditional Chinese medicine industry, the research on the key technology of green manufacturing of traditional Chinese medicine, "Technical system and Application of Separation Engineering of traditional Chinese Medicine based on membrane process", is summarized. In view of the common problems such as low production efficiency, low utilization ratio, high energy consumption, high pollution, low sterilization efficiency and so on, the preparation pretreatment in the production of traditional Chinese medicine is based on the characteristics, engineering principles and laws of the production process of traditional Chinese patent medicine. Taking membrane science and technology as the core, by constructing the scientific hypothesis of "traditional Chinese medicine solution environment" and introducing the scientific principle of complex systems, the research method of membrane mass transfer process based on computer chemistry method is established, and the bottleneck of engineering application of traditional Chinese medicine membrane technology is pointed out. To construct the technology integration strategy of "membrane process optimization" for traditional Chinese medicine materials, and carry out the research and development of key technologies and equipment, such as energy saving, consumption reduction, emission reduction, process optimization and so on, in the production of proprietary Chinese medicine. Forming a series of key common technologies of green manufacturing of traditional Chinese medicine based on membrane process with independent intellectual property rights, establishing an environmentally friendly production line that conforms to the characteristics of traditional Chinese medicine, and realizing the extraction and refining of preparation pretreatment in the production of traditional Chinese medicine industry, Concentration "and other links of high efficiency, environmental protection, stability and intelligent control." The membrane technology of traditional Chinese medicine takes water as the basic solvent and can retain the characteristics of traditional Chinese medicine. The membrane technology and its complete set of equipment have been extended to 29 provinces and cities in China, which has produced remarkable social and economic benefits. Membrane technology is fully in line with the construction of a resource-saving and environment-friendly society, as well as the development of circular economy. It is the key technology of green manufacturing of traditional Chinese medicine, and it will promote the technological progress of the pharmaceutical industry of traditional Chinese medicine in China. It plays an important role in improving labor productivity and resource utilization, and has a broad prospect of popularization and application.
【作者单位】：南京中医药大学江苏省中药资源产业化过程协同创新中心;南京中医药大学江苏省植物药深加工工程研究中心;南京工业大学特种分离膜国家工程研究中心;浙江工业大学;陕西中医药大学陕西省中药资源产业化过程协同创新中心;扬子江药业集团南京海陵中药制药工艺技术国家工程研究中心;江苏久吾高科技股份有限公司无机膜国家地方联合工程研究中心;南京中医药大学第一临床医学院;
【基金】：2017中国工程院咨询项目(2017-XZ-08) 国家自然科学基金资助项目(30572374,30171161,30873449) 国家科技部“十五”科技攻关计划项目(2004BA721A42);国家科技部“十一五”科技支撑计划项目(2006BAI09B07-03)
【分类号】：R283.6

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