离子液体选择性萃取分离磷脂酰丝氨酸和磷脂酰胆碱

发布时间：2018-05-10 07:48

本文选题：离子液体 + 分离　；参考：《化工学报》2017年09期

【摘要】：同系物分离是高纯度药物单体和化学品制备中的重要环节,磷脂酰丝氨酸是一类重要的药物和功能添加剂,其制备过程中的关键技术是磷脂酰丝氨酸与其他磷脂同系物的分离,但同系物之间结构相似、分离难度大。报道了以离子液体为介质选择性萃取分离磷脂酰丝氨酸和磷脂酰胆碱的方法,系统研究了离子液体结构和浓度、萃取温度对分离性能的影响。研究表明,离子液体的阴离子结构显著影响同系物的分离选择性,且离子液体与极性稀释剂之间存在协同萃取效应,离子液体的摩尔浓度仅为5%时,1-乙基-3-甲基咪唑溴/甲醇-正己烷两相体系中的磷脂酰丝氨酸和磷脂酰胆碱的选择性高达29.48。采用量子化计算初步研究了萃取机理,结果表明离子液体与磷脂之间形成了多重氢键和静电相互作用,从而促进了磷脂同系物之间的选择性分离。
[Abstract]:Homologous separation is an important step in the preparation of high purity drug monomers and chemicals. Phosphatidyl serine is an important class of drugs and functional additives. The key technology in the preparation process is the separation of phosphatidylserine from other phospholipid homologues. However, the structure of homologues is similar and the separation is difficult. The method of selective extraction of phosphatidyl serine and phosphatidylcholine using ionic liquid as the medium was reported. The effects of ionic liquid structure and concentration and extraction temperature on the separation performance were systematically studied. The results showed that the anionic structure of ionic liquids significantly affected the separation selectivity of homologues, and there was a synergistic extraction effect between ionic liquids and polar diluents. The selectivity of phosphatidyl serine and phosphatidylcholine in 1-ethyl-3-methyl imidazolium / methanol-n-hexane two-phase system was 29.48 when the molar concentration of ionic liquid was only 5. The extraction mechanism was preliminarily studied by quantization calculation. The results showed that the ionic liquid and phospholipids formed multiple hydrogen bonds and electrostatic interactions, which promoted the selective separation of phospholipid homologues.
【作者单位】：浙江大学化学工程与生物工程学院生物质化工教育部重点实验室;
【基金】：国家自然科学基金项目(21476192) 国家万人计划-青年拔尖人才~~
【分类号】：TQ028.32;TQ413.2

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