一种压电驱动微喷雾化干燥技术的研究
发布时间：2019-03-22 06:29
【摘要】：随着现代科技的发展，，微纳米粉体技术的应用涉及到食品、医药、化工、生物工程等诸多领域。微纳米粉体技术的研究涉及到微纳米粉体的制备技术、颗粒特性的描述与表征技术、颗粒表面改性技术等。其中，微纳米粉体制备技术作为微纳米粉体技术研究与应用的基础和前提显得尤为重要。同时，在生物医药领域，肺部吸入给药方式以非侵入方式传递到肺部，产生局部或全身治疗的作用，逐渐成为治疗哮喘的有效方式。当肺吸入药物粉体粒径为1~5μm时，药物作用最为有效。 本文针对生物肺吸入给药微纳药物粉体制备问题，分析研究微纳米粉体制备方法，提出采用压电驱动喷雾干燥方法制备生物微纳药物粉体。通过对技术方案的比较设计，采用纵径复合压电驱动方案进行料液的微喷雾化，并提出压电复合驱动微喷雾化干燥的整体技术方案。依据方案的研究，分析压电微喷雾化干燥工作过程，构建了微喷雾化数学模型，在数学模型的基础上，对生物微纳粉体喷雾干燥装置的关键结构雾化器的液腔结构尺寸、压电驱动材料结构以及驱动参数进行设计计算。 利用有限元分析软件对压电喷雾驱动过程进行压电仿真分析，模拟了液滴的形成过程，并利用构建的实验装置对压电微喷雾化干燥系统进行了粉体喷雾干燥实验研究。实验结果表明，纵径复合压电驱动喷雾干燥方式获得干燥粉体粒径分布为3~5μm，满足生物微纳药物粉体有效吸收范围的要求，且粒径分布均匀，粉体分散性良好。
[Abstract]:With the development of modern science and technology, the application of micro-nano-powder technology involves many fields such as food, medicine, chemical industry, bio-engineering and so on. The research of micro-nano-powder technology involves the preparation of micro-nano-powder, the description and characterization of particle characteristics, the surface modification of particles and so on. Among them, the preparation technology of micro-nano-meter powder is very important as the foundation and premise of the research and application of micro-nano-powder technology. At the same time, in the field of biomedicine, lung inhalation drug delivery to the lungs in a non-invasive manner, resulting in local or systemic treatment, has gradually become an effective way to treat asthma. When the particle size of lung inhaled drug powder was 1 ~ 5 渭 m, the drug effect was the most effective. In this paper, the preparation method of micro-nano-drug powder by bio-lung inhalation was analyzed and studied, and a piezoelectric-driven spray-drying method was proposed for the preparation of bio-nano-drug powder. Through the comparison and design of the technical scheme, the longitudinal-diameter composite piezoelectric driving scheme is adopted to spray the liquid and the whole technical scheme of the micro-spray drying with piezoelectric composite drive is put forward. According to the study of the scheme, the working process of piezoelectric micro-spray atomization drying is analyzed, and the mathematical model of micro-spray atomization is constructed. On the basis of the mathematical model, the liquid cavity structure size of the atomizer, which is the key structure of the bio-micro-nano powder spray drying device, is studied. The piezoelectric driving material structure and driving parameters are designed and calculated. The piezoelectric spray driving process was simulated by finite element analysis software, and the droplet formation process was simulated. The powder spray drying system of piezoelectric micro-spray atomization drying system was studied by using the built experimental device. The experimental results show that the particle size distribution of the powder is 3 ~ 5 渭 m, which meets the requirements of the effective absorption range of the bio-nano-drug powder, and the particle size distribution is uniform and the powder dispersion is good.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：TB4
[Abstract]:With the development of modern science and technology, the application of micro-nano-powder technology involves many fields such as food, medicine, chemical industry, bio-engineering and so on. The research of micro-nano-powder technology involves the preparation of micro-nano-powder, the description and characterization of particle characteristics, the surface modification of particles and so on. Among them, the preparation technology of micro-nano-meter powder is very important as the foundation and premise of the research and application of micro-nano-powder technology. At the same time, in the field of biomedicine, lung inhalation drug delivery to the lungs in a non-invasive manner, resulting in local or systemic treatment, has gradually become an effective way to treat asthma. When the particle size of lung inhaled drug powder was 1 ~ 5 渭 m, the drug effect was the most effective. In this paper, the preparation method of micro-nano-drug powder by bio-lung inhalation was analyzed and studied, and a piezoelectric-driven spray-drying method was proposed for the preparation of bio-nano-drug powder. Through the comparison and design of the technical scheme, the longitudinal-diameter composite piezoelectric driving scheme is adopted to spray the liquid and the whole technical scheme of the micro-spray drying with piezoelectric composite drive is put forward. According to the study of the scheme, the working process of piezoelectric micro-spray atomization drying is analyzed, and the mathematical model of micro-spray atomization is constructed. On the basis of the mathematical model, the liquid cavity structure size of the atomizer, which is the key structure of the bio-micro-nano powder spray drying device, is studied. The piezoelectric driving material structure and driving parameters are designed and calculated. The piezoelectric spray driving process was simulated by finite element analysis software, and the droplet formation process was simulated. The powder spray drying system of piezoelectric micro-spray atomization drying system was studied by using the built experimental device. The experimental results show that the particle size distribution of the powder is 3 ~ 5 渭 m, which meets the requirements of the effective absorption range of the bio-nano-drug powder, and the particle size distribution is uniform and the powder dispersion is good.
【学位授予单位】：苏州大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：TB4
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