94遗传因素在风险决策加工中的作用

发布时间：2016-11-08 15:54

本文关键词：遗传因素在风险决策加工中的作用，，由笔耕文化传播整理发布。

第2期何清华等:遗传因素在风险决策加工中的作用2；Psychiatry,62(2),146–152；Hariri,A.R.,&Holmes,；He,Q.,Xue,G.,Chen,C.,Lu,；He,Q.,Xue,G.,Chen,C.,Lu,；Homberg,J.R.,vandenBos,R；Hu,X.-Z.,Lipsky,R.H.,Zhu；Johns

第2期何清华等: 遗传因素在风险决策加工中的作用 201

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The Role of Genes in Risky Decision Making

HE Qinghua1; XUE Gui2; CHEN Chunhui2; DONG Qi2; CHEN Chuansheng3

(1 Faculty of Psychology, Southwest University, Chongqing 400715, China)

(2 National Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China)

(3 University of California, Irvine, CA 92697, USA)

Abstract: Risky decision making is a complex process that involves weighing different options in terms of their likelihood of potential rewards and risks. It is one of the most important cognitive functions of the human brain. People differ significantly in their everyday risky decision making, partly influenced by genetic and environmental factors. In this article, we first review recent studies investigating the effect of genetic factors on risky decision making, including twin studies and molecular genetic studies. Candidate genes included dopamine-related genes (e.g., COMT and DAT), serotonin-related genes (e.g., SLC6A and TPH1), and other genes (e.g., BDNF). We then discussed the contribution of environment as well as gene-environment interaction to risky decision making. Recent studies have also incorporated brain anatomy and functions as endophenotypes of risky decision making in molecular genetic research. In the final section,

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we outline directions of future research that should emphasize gene-environment interactions and brain structure and functions as the mediators between genes and risky decision making.

Key words: heritability; genes; risky decision making; environment; gene-environment interaction; brain

通讯作者简介：

陈传升博士, 美籍华人, 美国加州大学尔湾分校心理与行为系、教育系、亚洲研究中心、认知神经科学中心教授。1992年获美国密歇根大学发展心理学博士学位。他的研究涉猎广泛, 善于从多学科的角度研究文化、大脑、遗传和认知之间的关系。他与第一作者何清华博士合作的研究主要采用基因技术和脑成像技术来考察风险决策的基因机制和神经机制, 并试图揭示那些具有风险决策障碍的相关精神疾病的发病机制。

Chuansheng Chen, Ph.D., Professor of Department of Psychology and Social Behavior, School of Education, Center for Asian studies, and Center of Cognitive Neuroscience at University of California, Irvine. He obtained his Ph.D. degree in developmental psychology from University of Michigan in 1992. He has diverse research interests and takes an interdisciplinary approach to studying the relationship between culture, brain, genes, and cognition. Collaborating with Dr. Qinghua He, the first author of this work, he used molecular genetic and neuroimaging techniques to investigate the genetic and neural bases of risky decision making, as well as the underlying mechanisms of psychiatric disorders with decision making deficits.

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