成瘾人群的决策障碍：研究范式与神经机制39

发布时间：2017-01-05 14:41

本文关键词：成瘾人群的决策障碍:研究范式与神经机制，，由笔耕文化传播整理发布。

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第5期严万森等: 成瘾人群的决策障碍：研究范式与神经机制 663

Research Paradigms and Neural Mechanisms for Decision-making Deficits in

Addicts

YAN Wan-Sen1,3; LI Shu2; SUI Nan1

(1Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China) (2Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China)

(3Graduate University of the Chinese Academy of Sciences, Beijing 100049, China)

Abstract: Drug addicts and pathological gamblers usually prefer immediate reward and ignore the future consequences. They are inclined to choose the bad options those bring immediate gains but long-term losses, which implies a kind of decision-making deficits. The Delay Discounting Task (DDT), the Iowa Gambling Task (IGT) and the Cambridge Gamble Task (CGT) are mainly three typical research paradigms and methods on decision -making deficits including impulsivity, myopia and risk-taking in addicts. Studies in recent years have demonstrated that the prefrontal cortex (PFC) plays an important role in human decision-making, such as the ventromedial prefrontal cortex (VMPFC), the orbitofrontal cortex (OFC) and the dorsolateral prefrontal cortex (DLPFC). Future directions in this area are introduced and anticipated. Key words: addiction; decision-making deficit; delay discounting; gambling task; PFC

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