早产儿感染耐美罗培南肺炎克雷伯菌的危险因素分析

发布时间：2018-01-18 06:17

  本文关键词：早产儿感染耐美罗培南肺炎克雷伯菌的危险因素分析　出处：《中华医院感染学杂志》2016年04期 　论文类型：期刊论文

  更多相关文章： 早产儿 肺炎克雷伯菌 美罗培南 危险因素

【摘要】：目的探讨早产儿感染耐美罗培南肺炎克雷伯菌的危险因素,从而更有针对性地预防治疗肺炎克雷伯菌感染。方法 2013年3月-2015年3月对医院65例早产儿确诊感染耐美罗培南肺炎克雷伯菌的临床资料进行回顾性分析,并与同期住院122例早产儿对美罗培南敏感肺炎克雷伯菌进行比较,对肺炎克雷伯菌医院感染的危险因素进行分析。结果单因素分析显示,早产儿耐美罗培南肺炎克雷伯菌感染的危险因素包括,出生胎龄、出生体质量、住院天数≥1个月、接受过机械通气≥5d、经外周静脉穿刺中心静脉插管、静脉营养≥2周、使用美罗培南抗菌药物治疗(≥7d)、使用三代头孢抗菌药物等,差异有统计学意义(P0.05);多因素logistic回归分析发现,使用美罗培南治疗(≥7d)为独立危险因素(OR=2.756,95%CI 1.083~7.014)。结论根据药敏试验结果,合理使用抗菌药物,减少早产儿美罗培南不必要的使用,以减少其耐药性发生,有利于控制耐美罗培南肺炎克雷伯菌的传播。
[Abstract]:Objective to investigate the risk factors of preterm infants infected with Klebsiella pneumoniae resistant to meropenem. Thus more targeted prevention and treatment of Klebsiella pneumoniae infection. From March 2013 to March 2015, the clinical data of 65 preterm infants infected with Klebsiella pneumoniae resistant to meropenem were retrospectively analyzed. The risk factors of nosocomial infection of Klebsiella pneumoniae were analyzed and compared with 122 premature infants in the same period. Results the univariate analysis showed that the risk factors of nosocomial infection of Klebsiella pneumoniae were analyzed. The risk factors of Klebsiella pneumoniae infection in preterm infants included gestational age, birth weight, length of stay 鈮，

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