ICU脓毒症患者中指导抗生素停用的血清PCT最佳水平范围探讨

发布时间：2018-03-25 17:12

  本文选题：脓毒症　切入点：降钙素原　出处：《山东医药》2016年01期

【摘要】：目的探讨指导ICU脓毒症患者抗生素停用的血清降钙素原(PCT)最佳水平范围。方法收入ICU的158例脓毒症患者,全部按照抗生素使用指南及临床经验进行抗生素治疗。检测所有患者停用抗生素时血清PCT水平,按血清PCT水平分为A、B、C、D、E、F组,其PCT水平分别为0.1、0.1~0.25、0.25~0.5、0.5~2、2~10、≥10 ng/m L,比较各组入院28 d内的病死率、抗生素使用时间及住院时间。结果 C、D、E、F组较A、B组病死率增加(P均0.05);C、D、E、F组中,除C组与F组以及D组与F组患者病死率比较差异有统计学意义(P均0.05),其余各组病死率比较差异无统计学意义(P均0.05);A、B组病死率比较差异无统计学意义(P0.05),但A组较B组抗生素使用时间与住院时间增加(P分别为0.023、0.021)。结论 ICU脓毒症患者血清PCT水平在0.1~0.25 ng/m L时宜停用抗生素。
[Abstract]:Objective to explore the optimal range of serum procalcitonin (ICU) levels for patients with ICU sepsis to stop using antibiotics. Methods 158 patients with ICU were enrolled in the study. All patients were treated with antibiotics according to the guidelines of antibiotic use and clinical experience. The serum PCT level was measured when all patients stopped using antibiotics. The PCT levels of the two groups were 0. 1 / 0. 1 ~ 0. 25 ~ 0. 25 ~ 0. 5 ~ 0. 5 / 2 ~ (2 +), 鈮，

本文编号：1664078