醒脑静注射液联合床旁高流量持续血液净化治疗脓毒性休克48例临床分析

发布时间：2018-08-06 19:12

【摘要】：目的观察醒脑静注射液联合床旁高流量持续血液净化治疗脓毒性休克毒热内盛证的疗效,以及对血清肿瘤坏死因子(TNF-α)和神经元特异性烯醇化酶(NSE)水平的影响。方法选择符合条件病例共96例,参照随机数字表法分为常规治疗组和醒脑静组,两组均48例。除了基础对症治疗,常规治疗组给予床旁高流量持续血液净化(CBP)治疗;醒脑静组在常规治疗组基础上给予醒脑静注射液治疗,两组患者均连续治疗1周。比较两组的中医主要症状评分、急性生理和慢性健康状况评分Ⅱ(APACHEⅡ)和Marshall评分;检测两组血清TNF-α和NSE水平检测。结果醒脑静组治疗后中医主要症状评分高热、烦躁、神昏、恶心呕吐评分均显著低于常规治疗组(P0.01);醒脑静组脑电图疗效总有效率为83.33%,常规治疗组为60.42%,醒脑静组明显高于常规治疗组(P0.05);治疗后3d和1周,醒脑静组APACHEⅡ和Marshall评分均显著低于同期常规治疗组(P0.01);治疗后,醒脑静组TNF-α和NSE水平均显著低于常规治疗组,比较差异有统计学意义(P0.01)。结论在西医常规基础治疗上,醒脑静注射液联合床旁高流量CBP治疗脓毒性休克毒热内盛证可明显改善患者临床症状,抑制患者血清TNF-α和NSE水平可能与上述治疗效果密切相关。
[Abstract]:Objective to observe the effect of Xingnaojing injection (XNJI) combined with continuous blood purification with high flow rate in the treatment of hypertoxic heat syndrome in septic shock and its effect on serum tumor necrosis factor (TNF- 伪) and neuron-specific enolase (NSE) levels. Methods 96 cases were divided into routine treatment group and Xingnaojing group, 48 cases in both groups. In addition to the basic symptomatic treatment, the conventional treatment group was treated with continuous blood purification (CBP) by high flow beside the bed, while the Xingnaojing group was treated with Xingnaojing injection on the basis of the routine treatment group, and the two groups were treated continuously for one week. The scores of TCM main symptoms, acute physiology and chronic health status 鈪，

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