北京社区人群血浆叶酸水平及其影响因素的相关性研究

发布时间：2018-08-11 16:16

【摘要】：目的了解北京社区人群血浆叶酸水平,探究影响叶酸水平的相关因素。方法采用横断面研究设计,对北京石景山社区居民进行问卷调查及血浆叶酸水平测定。研究共纳入5 227名研究对象。结果研究人群血浆叶酸的中位数(P25,P75)为6.18(4.98~8.18)ng/ml,其中男性为5.29(4.49~6.75)ng/ml,明显低于女性[6.79(5.45~9.02)ng/ml]。血浆叶酸水平(自然对数)的多因素线性回归分析显示:肥胖(β=-0.037,P=0.008 6)、吸烟(β=-0.118,P0.000 1)的个体叶酸水平(自然对数)较低;较高年龄(β=0.003,P0.000 1)、女性(β=0.186,P0.000 1)、更高的受教育程度(β=0.039,P=0.000 5)、近3个月来每周不少于5 d的运动(β=0.037,P=0.008 6)及每周不少于3 d补充B族维生素(β=0.299,P0.000 1)的个体血浆叶酸水平(自然对数)较高。按性别分层分析,肥胖及运动仅与女性的叶酸水平(自然对数)有关联(P0.05),而其他因素对叶酸的影响趋势无性别差异。结论北京社区人群血浆叶酸处于较低水平;个体差异、生活方式及维生素的补充对叶酸水平产生影响。
[Abstract]:Objective to investigate the plasma folic acid level and its related factors in Beijing community. Methods A cross-sectional study was conducted to investigate the level of plasma folic acid in Shijingshan community residents in Beijing. A total of 5,227 subjects were included in the study. Results the median of plasma folic acid (P25 / P75) was 6.18 (4.98 ~ 8.18) ng / ml in the study group, and 5.29 (4.49 ~ 6.75) ng / ml in male, which was significantly lower than that in female [6.79 (5.45 ~ 9.02) ng/ml]. The multivariate linear regression analysis of plasma folic acid level (natural logarithm) showed that the individual folic acid level (natural logarithm) was lower in obesity (尾 -0.037) and smoking (尾 -0.118 P0.000 1). At a higher age (尾 = 0.003), female (尾 = 0.186), higher educational level (尾 = 0.039), exercise for not less than 5 days a week (尾 = 0.037) and vitamin B supplementation (尾 = 0.299P ~ (0.000 1), plasma folic acid level (natural logarithm) was higher than that of group B vitamin supplement (尾 -0.299p _ (0.0001) for at least 3 days per week in the last three months. By sex stratification analysis, obesity and exercise were only associated with folic acid level (natural logarithm) of women (P0.05), while other factors had no gender difference on the trend of folic acid. Conclusion the level of plasma folic acid in Beijing community population is low, and individual differences, lifestyle and vitamin supplementation influence the level of folic acid.
【作者单位】：北京大学第一医院心血管内科;
【基金】：密歇根大学-北京大学医学部转化医学联合研究项目(BMU20110177)
【分类号】：R446.1

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