151例淋巴瘤外周血造血干细胞采集影响因素分析

发布时间：2018-09-17 09:24

【摘要】：目的:分析淋巴瘤患者外周血干细胞动员采集过程中各相关因素对干细胞采集量的影响,以期能更好地提高病人干细胞采集的效率。方法:回顾性分析本院151例淋巴瘤患者外周血造血干细胞移植动员采集过程中各种因素对所采集的造血干细胞数量的影响。这些因素包括年龄、性别、身高、体重、病理类型、分期、动员方案、采集天数、输注血制品、病程时间及所经历化疗疗程等。结果:单因素分析发现,性别、身高、体重、病理类型、分期、动员方案、采集天数、血制品输注等对干细胞采集数量影响不显著;CD34~+细胞采集量和年龄显著相关(r=-0.248,P=0.002),年龄大于50岁后,CD34~+细胞的采集量下降明显,大于60岁CD34~+细胞采集量降低显著;患者患病病程时间和动员前所经历化疗疗程数对CD34~+细胞采集量有显著影响。每次CD34~+细胞采集量与采集前血常规指标中的WBC(r=0.053,P=0.527)无显著相关,但与单个核细胞百分数(r=0.260,P=0.002)和单个核细胞绝对值(r=0.338,P=0.00003)相关显著。结论:60岁以下,动员前化疗疗程较少,动员后单个核细胞数在(2-6)×109/L之间患者可能有更高的外周血造血干细胞采集量。
[Abstract]:Objective: to analyze the influence of various factors on the collection of peripheral blood stem cells in patients with lymphoma, in order to improve the efficiency of stem cell collection. Methods: the effects of various factors on the number of hematopoietic stem cells collected from 151 patients with lymphoma were analyzed retrospectively. These factors included age, sex, height, weight, pathological type, staging, mobilization program, days of collection, transfusion of blood products, duration of course of disease and the course of chemotherapy. Results: univariate analysis showed that sex, height, weight, pathological type, stage, mobilization program, collecting days, There was no significant correlation between the amount of CD34 ~ cells collected and the age (r ~ (-0.248) P ~ (0.002). After the age of 50 years old, the collection of CD34 ~ cells decreased significantly, and that of CD34~ cells more than 60 years old decreased significantly. The duration of disease and the number of chemotherapeutic courses before mobilization had a significant effect on the collection of CD34~ cells. There was no significant correlation between the amount of CD34~ cells collected and the WBC (rn 0.053) in the blood routine index before collection, but there was a significant correlation with the percentage of mononuclear cells (r = 0.260) and the absolute value of mononuclear cells (r = 0.338P0. 00003). Conclusion under 60 years old, the chemotherapy course before mobilization is less, the number of mononuclear cells after mobilization is (2-6) 脳 10 ~ 9 / L patients may have higher peripheral blood stem cell collection.
【作者单位】：北京大学肿瘤医院暨北京市肿瘤防治研究所输血科恶性肿瘤发病机制及转化研究教育部重点实验室;
【分类号】：R457.7;R733.1

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