儿童患者中分离189株卡他莫拉菌的分布和耐药性分析

发布时间：2018-12-31 11:14

【摘要】：目的研究儿童患者中分离的卡他莫拉菌临床分布及耐药性,指导临床合理用药。方法对2013-2014年北京儿童医院临床送检标本分离出的189株卡他莫拉菌的分布、产酶情况和药敏结果进行回顾性分析。采用纸片扩散法作药敏试验,头孢硝噻吩纸片法测定β内酰胺酶。依照2013年CLSI M45-A2标准判断结果。结果卡他莫拉菌多分离于婴幼儿患者,常混合其他细菌。β内酰胺酶阳性率为95.7%,对阿莫西林-克拉维酸、甲氧苄啶-磺胺甲唑、四环素耐药率分别为0、2.1%和4.2%。对红霉素和阿奇霉素耐药严重,耐药率达到了82.5%和83.1%。结论儿童患者携带的卡他莫拉菌β内酰胺酶阳性率很高,其高产酶特点使青霉素类药物不能作为临床一线用药。卡他莫拉菌对大环内酯类耐药性较高,应引起临床重视,并加强对其耐药监测。
[Abstract]:Objective to study the clinical distribution and drug resistance of isolated strains of Morrah in children and to guide rational drug use. Methods the distribution, enzyme production and drug sensitivity of 189 strains of Mora carinii isolated from clinical samples of Beijing Children's Hospital from 2013 to 2014 were analyzed retrospectively. Drug sensitivity test was performed by disk diffusion method and 尾-lactamase was determined by ceftathiophene disk method. The results were judged according to the 2013 CLSI M45-A2 standard. Results the positive rate of 尾 lactamases was 95.70.The positive rate of amoxicillin clavulanic acid, trimethoprim sulfamethazol, amoxicillin, trimethoprim and sulfamethazol was 95.7%. The tetracycline resistance rates were 0.1% and 4.2%, respectively. The resistance rates of erythromycin and azithromycin were 82.5% and 83.1% respectively. Conclusion the positive rate of 尾 -lactamases carried by children patients is very high, and the characteristics of high enzyme production make penicillin drugs can not be used as a clinical first-line drug. Because of its high resistance to macrolides, it should be paid more attention in clinic and surveillance of drug resistance should be strengthened.
【作者单位】：首都医科大学附属北京儿童医院细菌室儿科学国家重点学科;
【分类号】：R446.5

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