427株黏质沙雷菌临床分布及耐药性

发布时间：2019-01-18 21:05

【摘要】：目的了解临床分离的黏质沙雷菌临床分布及耐药情况,为临床合理使用抗菌药物、预防和控制感染提供依据。方法对某院2012年1月1日—2015年12月31日临床分离的427株黏质沙雷菌进行分析,采用纸片扩散法检测其对常用抗菌药物的敏感性。结果 427株黏质沙雷菌标本来源以呼吸道为主(70.26%),主要为痰(64.87%);科室分布主要为重症监护病房(ICU,19.44%),其次为中西医结合科(15.46%)和康复科(13.58%)。黏质沙雷菌对头孢哌酮/舒巴坦、厄他培南、头孢吡肟、头孢他啶、阿米卡星、亚胺培南、左氧氟沙星和哌拉西林/他唑巴坦的耐药率均10%;对环丙沙星、庆大霉素、妥布霉素、头孢曲松、复方磺胺甲口恶唑和氨曲南的耐药率为10%~30%。4年间耐药率变化有统计学意义(P0.05)的有头孢哌酮/舒巴坦、环丙沙星、头孢曲松、阿米卡星、氨曲南和复方磺胺甲口恶唑;2012—2013年黏质沙雷菌对头孢哌酮/舒巴坦、环丙沙星、头孢曲松、氨曲南和复方磺胺甲口恶唑耐药率明显增加,之后耐药率趋于平稳;对头孢哌酮/舒巴坦则耐药性降低。结论黏质沙雷菌对大部分常用抗菌药物的敏感性较好,但耐药性有增加的趋势;其中厄他培南、头孢他啶、左氧氟沙星和哌拉西林/他唑巴坦敏感率高,可作为临床治疗相关感染的经验用药。
[Abstract]:Objective to investigate the clinical distribution and drug resistance of clinical isolates of Mycobacterium Shareh so as to provide evidence for rational use of antimicrobial agents and prevention and control of infection. Methods 427 strains of Mycobacterium Shareh isolated from a hospital from January 1, 2012 to December 31, 2015 were analyzed. The susceptibility to common antimicrobial agents was detected by disk diffusion method. Results 427 strains of M. Shareh were mainly from respiratory tract (70.26%) and sputum (64.87%). The distribution of departments was mainly in intensive care unit (ICU,19.44%), followed by integrated Chinese and western medicine (15.46%) and rehabilitation (13.58%). The resistance rates of M. Shareh to cefoperazone / sulbactam, etapenem, cefepime, ceftazidime, amikacin, imipenem, levofloxacin and piperacillin / tazobactam were all 10. The resistance rates of ciprofloxacin, gentamycin, tobramycin, ceftriaxone, compound sulfamethoxazole and aztreonam in ciprofloxacin, gentamycin, tobramycin, cefoperazone / sulbactam were significantly different (P0.05), and the resistance rates of ciprofloxacin, gentamycin, tobramycin, cefoperazone / sulbactam were significantly different (P0.05). Keywords ciprofloxacin, ceftriaxone, amikacin, aztreonam and compound sulfamethoxazole; In 2012-2013, the resistance rate of M. Shareh to cefoperazone / sulbactam, ciprofloxacin, ceftriaxone, aztreonam and compound sulfamethoxazole increased significantly, and the resistance rate to cefoperazone / sulbactam decreased. Conclusion the sensitivity of most commonly used antimicrobial agents is good, but the drug resistance tends to increase. Among them, ertapenem, ceftazidime, levofloxacin and piperacillin / tazobactam have high sensitivity.
【作者单位】：中南大学湘雅医院;
【基金】：[基金项目]湖南省教育厅湘教通(2012)594号
【分类号】：R446.5

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