适应水中运动对自闭症儿童行为及血清白细胞介素水平的影响

发布时间：2018-05-02 13:16

本文选题：适应水中运动 + 自闭症　；参考：《广州体育学院》2017年硕士论文

【摘要】：研究目的:本研究通过观察4周适应水中运动干预前后自闭症儿童血清白细胞介素水平的变化,探讨适应水中运动对自闭症儿童康复干预的机制,为自闭症儿童运动干预提供循证支持。研究方法:选取广州市14名轻中度自闭症儿童作为研究对象,均为男孩,年龄为4~10岁。根据CARS量表,将14名受试者随机分为实验组和对照组,每组各7人。实验组进行4周有规律的适应水中运动,每周五次课,每次课90分钟,对照组进行日常生活模式。受试者采样时间:早晨7:30-8:00(空腹状态),分别在干预前后采集静脉血,应用酶联免疫吸附法(ELISA)检测血清IL-1β、IL-2R、IL-4、IL-6水平。研究结果:1.与干预前相比,适应水中运动干预后,实验组自闭症儿童的行为评定量表(ABC)的躯体运动(干预前:6.556±6.401,干预后:4.4447±5.501)和生活自理能力(干预前:9.556±6.061,干预后:7.278±5.633)的分值较干预前减少,且差异有显著性意义(P0.05),而感觉(干预前:9.83±7.326,干预后:9.111±5.572)、社会交往(干预前:10.889±8.858,干预后:9.50±8.001)、语言(干预前12.833±7.422,干预后:12.222±8.981)和总分值(干预前:49.66±28.506,干预后:42.556±26.27)均有下降趋势,但差异无显著性意义(P0.05)。2.与干预前相比,适应水中运动干预后,对照组自闭症儿童的行为评定量表(ABC)的躯体运动(干预前:8.357±7.239,干预后:11.214±7.392)的分值上升,且差异有显著性意义(P0.05);而感觉(干预前:10.429±5.543,干预后:11.571±5.867)、社会交往(干预前:11.571±7.165,干预后:12.357±6.368)、语言(干预前:8.786±7.106,干预后:11.143±8.113)、生活自理能力(干预前:8.571±3.715,干预后:10.929±4.323)和总分(干预前:47.714±25.436,干预后:57.214±23.671)的分值均有上升趋势,但差异无显著性意义(P0.05)。3.适应水中运动干预后,实验组和对照组孤独症行为量表差值比较显示,躯体运动(实验组:-2.11±2.928;对照组:2.86±4.865)、生活自理能力(实验组:-2.28±3.659;对照组:2.36±5.372)和总分(实验组:-7.11±15.465;对照组:9.50±16.842)分值有非常显著性差异(P0.01);感觉(实验组:-0.72±5.539;对照组:1.14±3.939)、社会交往(实验组:-1.39±4.742;对照组:0.79±4.336)和语言(实验组:-0.61±6.391;对照组:2.36±5.826)分值无显著性差异(P0.05)。4.与干预前相比,适应水中运动干预后,实验组自闭症儿童血清IL-1β(干预前:14.213±0.185;干预后:13.984±0.204)和IL-4(干预前:19.257±1.363;干预后:18.711±1.113)水平下降,且差异有显著性意义(P0.05);IL-2R(干预前:703.744±280.644;干预后:562.391±203.789)和IL-6(干预前:27.667±10.343;干预后:14.414±14.267)水平下降,但差异无显著性意义(P0.05)。5.与干预前相比,适应水中运动干预后,对照组自闭症儿童血清IL-1β(干预前:14.086±0.554;干预后:14.290±0.404)、IL-4(干预前:19.010±1.251;干预后:19.035±1.048)和IL-6(干预前:20.212±7.396;干预后:22.366±6.533)水平均上升,但差异无显著性意义(P0.05);IL-2R(干预前:836.075±218.336;干预后:754.120±213.800)水平下降,但差异无显著性意义(P0.05)。6.适应水中运动干预后,实验组和对照组血清白细胞介素差值比较显示,IL-4(实验组:-0.912±0.506;对照组:0.025±0.239)水平有显著性差异(P0.05);IL-1β(实验组:-0.229±0.210;对照组:0.204±0.723)、IL-2R(实验组:-141.353±187.500;对照组:-81.955±130.021)和IL-6(实验组:-13.254±16.049;对照组:2.154±6.606)水平无显著性差异(P0.05)。研究结论:1.适应水中运动能够改善自闭症患儿的躯体运动和生活自理能力。2.适应水中运动可以显著性降低自闭症儿童血清IL-1β、IL-4水平。3.适应水中运动可能通过下调血清IL-1β水平来改善自闭症儿童的躯体运动。
[Abstract]:Objective : To investigate the changes of serum interleukin - 2 ( IL - 1尾 , IL - 2R , IL - 4 , IL - 6 ) in children with autism before and after intervention by observing the changes of serum levels of IL - 1尾 , IL - 2R , IL - 4 and IL - 6 in children with autism before and after intervention . After intervention , the scores of the behavioral assessment scale ( ABC ) of the control group were significantly higher than that before intervention ( before intervention : 10.429 卤 5.543 , after intervention : 12.357 卤 6.368 ) , and there was no significant difference ( P0.05 ) . After intervention , the difference between the experimental group and the control group autism behavior scale showed that the body movement ( experimental group : - 2.11 卤 2.928 ; control group : 2.86 卤 4.865 ) , life self - care ability ( experimental group : Compared with the control group , the levels of IL - 1尾 ( before intervention : 14.213 卤 4.742 ; control group : 0.79 卤 4.336 ) and language ( experimental group : - 0.61 卤 6.391 ; control group : 1.39 卤 4.742 ; control group : 0.79 卤 4.336 ) and language ( experimental group : - 0.61 卤 6.391 ; control group : 2.36 卤 5.826 ) decreased significantly ( P0.05 ) . The levels of IL - 1尾 ( pre - intervention : 14.086 卤 0.554 ; post - intervention : 14.290 卤 0.404 ) , IL - 4 ( before intervention : 19.010 卤 1.251 ; post - intervention : 19.035 卤 1.048 ) and IL - 6 ( pre - intervention : 20.212 卤 7.396 ) , IL - 2R ( experimental group : - 1.353 卤 187.500 ; control group : - 1.955 卤 13.021 ) and IL - 6 ( experimental group : - 13.254 卤 16.49 ; control group : 2.154 卤 6.606 ) . IL - 4 levels . 3 . Adaptation to water movement may improve the body movement of children with autism by downregulation of serum IL - 1尾 levels .

【学位授予单位】：广州体育学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：G861;G804.2

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